Patents by Inventor David Wiemer

David Wiemer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRIAZOLE BISPHOSPHONATE GERANYLGERANYL DIPHOSPHATE SYNTHASE INHIBITORS
    Publication number: 20210393654
    Abstract: Disclosed herein are inhibitors of the GGDPS enzyme, and methods for their use in treating or preventing diseases, such as multiple myeloma. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are described.
    Type: Application
    Filed: May 27, 2021
    Publication date: December 23, 2021
    Inventors: Sarah Holstein, David Wiemer
  • Triazole bisphosphonate geranylgeranyl diphosphate synthase inhibitors
    Patent number: 11033560
    Abstract: Disclosed herein are inhibitors of the GGDPS enzyme, and methods for their use in treating or preventing diseases, such as multiple myeloma. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are described.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: June 15, 2021
    Assignees: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA, UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Sarah Holstein, David Wiemer
  • TRIAZOLE BISPHOSPHONATE GERANYLGERANYL DIPHOSPHATE SYNTHASE INHIBITORS
    Publication number: 20200121701
    Abstract: Disclosed herein are inhibitors of the GGDPS enzyme, and methods for their use in treating or preventing diseases, such as multiple myeloma. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are described.
    Type: Application
    Filed: April 25, 2018
    Publication date: April 23, 2020
    Inventors: Sarah Holstein, David Wiemer
  • Therapeutic bisphosphonates
    Patent number: 9745331
    Abstract: The invention provides novel pyrophosphate synthase inhibitors of formula I and formula II as well salts thereof; the invention also provides compositions comprising such inhibitors and methods for their use.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: August 29, 2017
    Assignee: University of Iowa Research Foundation
    Inventor: David Wiemer
  • THERAPEUTIC BISPHOSPHONATES
    Publication number: 20150322099
    Abstract: The invention provides novel pyrophosphate synthase inhibitors of formula I and formula II as well salts thereof; the invention also provides compositions comprising such inhibitors and methods for their use.
    Type: Application
    Filed: July 3, 2013
    Publication date: November 12, 2015
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventor: David Wiemer
  • Schweinfurthins and uses thereof
    Patent number: 8686016
    Abstract: Disclosed is a method for preventing or treating an undesirable condition in a subject carrying cells homozygous null for the neurofibromatosis type 1 gene or subjects that are haploinsufficient for the neurofibromatosis type 1 gene, the method comprising administering to a subject in need thereof an effective amount of a schweinfurthin or schweinfurthin analog or derivative, or a pharmaceutically acceptable salt, prodrug, hydrate, or solvate thereof. Also disclosed is a new schweinfurthin compound of the formula.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: April 1, 2014
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, University of Iowa Research Foundation
    Inventors: Karlyne Reilly, Thomas Turbyville, John A. Beutler, David Wiemer
  • SCHWEINFURTHINS AND USES THEREOF
    Publication number: 20120095089
    Abstract: Disclosed is a method for preventing or treating an undesirable condition in a subject carrying cells homozygous null for the neurofibromatosis type 1 gene or subjects that are haploinsufficient for the neurofibromatosis type 1 gene, the method comprising administering to a subject in need thereof an effective amount of a schweinfurthin or schweinfurthin analog or derivative, or a pharmaceutically acceptable salt, prodrug, hydrate, or solvate thereof. Also disclosed is a new schweinfurthin compound of the formula.
    Type: Application
    Filed: April 30, 2010
    Publication date: April 19, 2012
    Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Karlyne Reilly, Thomas Turbyville, John A. Beutler, David Wiemer
  • Geranylgeranyl pyrophosphate synthase inhibitors
    Publication number: 20060052347
    Abstract: The invention provides novel pyrophosphate synthase inhibitors of formula I as well as compositions comprising such inhibitors and methods for their use.
    Type: Application
    Filed: August 25, 2005
    Publication date: March 9, 2006
    Inventors: David Wiemer, Raymond Hohl
  • Compounds and methods for detecting tripeptidyl protease I
    Patent number: 6824998
    Abstract: The present invention provides compounds useful for the detection of the enzyme tripeptidyl protease I (TPP-1). The invention also provides methods of making such compounds, methods of using such compounds, and kits and compositions containing such compounds. In one embodiment, Gly-L-Pro-L-Ser-1-anthraquinonylhydrazide, in combination with p-anisaldehyde, is used to detect TPP-1.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: November 30, 2004
    Assignee: University of Iowa Research Foundation
    Inventors: Beverly L. Davidson, David Wiemer
  • Compounds and methods for detecting tripeptidyl protease I
    Publication number: 20040185520
    Abstract: The present invention provides compounds useful for the detection of the enzyme tripeptidyl protease I (TPP-1). The invention also provides methods of making such compounds, methods of using such compounds, and kits and compositions containing such compounds. In one embodiment, Gly-L-Pro-L-Ser-1-anthraquinonylhydrazide, in combination with p-anisaldehyde, is used to detect TPP-1.
    Type: Application
    Filed: March 19, 2003
    Publication date: September 23, 2004
    Inventors: Beverly L. Davidson, David Wiemer
  • Isoprenoid analog compounds and methods of making and use thereof
    Publication number: 20040167102
    Abstract: The invention provides compounds of formula I: 1
    Type: Application
    Filed: February 17, 2004
    Publication date: August 26, 2004
    Applicant: University of Iowa Research Foundation.
    Inventors: David Wiemer, Raymond J. Hohl
  • Isoprenoid analog compounds and methods of making and use thereof
    Patent number: 6727234
    Abstract: The invention provides compounds of formula I: wherein X, R1, R2, and n have any of the values defined in the specification, and their pharmaceutically acceptable salts. The compounds are useful, for example, for blocking prenylation transferase enzymes, for probing or diagnosing protein prenylation processes, and for treating cancer in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and intermediates useful for the synthesis of compounds of formula I.
    Type: Grant
    Filed: April 3, 2002
    Date of Patent: April 27, 2004
    Assignee: University of Iowa Research Foundation
    Inventors: David Wiemer, Raymond J. Hohl
  • Isoprenoid analog compounds and methods of making and use thereof
    Publication number: 20030022869
    Abstract: The invention provides compounds of formula I: 1
    Type: Application
    Filed: April 3, 2002
    Publication date: January 30, 2003
    Inventors: David Wiemer, Raymond J. Hohl