Abstract: Example implementations include a method of constructing a dentition structure by a topographic mesh therefor, by generating one or more edges geometrically connecting one or more landmarks, the landmarks being associated with one or more physical features of a physical object, generating a mesh model including the edges and the landmarks, identifying at least one boundary of the mesh model based on one or more of the edges and the landmarks, selecting at least one mesh region associated with at least one corresponding physical feature of the physical object, projecting the selected mesh region onto a predetermined projection plane to form a mesh projection, and constructing the physical features of the physical object based on the mesh projection.

Abstract: Example implementations include a method of mapping and segmenting a physical object by obtaining a plurality of two-dimensional images of a physical object, generating a three-dimensional object model of the physical object based at least partially on one or more of the two-dimensional images, obtaining a plurality of landmarks associated with the object model, one or more of the landmarks being respectively associated with corresponding three-dimensional coordinates and object plane identifiers, and generating at least one landmark plane at the object model including one or more of the landmarks including the object plane identifiers.

Abstract: Provided herein are compositions and methods related to modified prime editing guide RNAs.

Abstract: Example implementations also include a method of generating a diagnostic model and user interface presentation based on individual anatomical features, by generating a distance associated with a subset of anatomical features, characterizing the anatomical features based on one or more feature metrics, generating one or more diagnostic language objects based on one or more diagnostic language metrics, segmenting one or more of the anatomical features based on a diagnostic template, embedding one or more of the segments anatomical features in the diagnostic template, and modifying at least one of the diagnostic language objects, in response to a determination that the diagnostic language object is associated with a separate branch of the tree from another one of the diagnostic language objects.

Abstract: Example implementations include a method of constructing a dentition structure by a topographic mesh therefor, by generating one or more edges geometrically connecting one or more landmarks, the landmarks being associated with one or more physical features of a physical object, generating a mesh model including the edges and the landmarks, identifying at least one boundary of the mesh model based on one or more of the edges and the landmarks, selecting at least one mesh region associated with at least one corresponding physical feature of the physical object, projecting the selected mesh region onto a predetermined projection plane to form a mesh projection, and constructing the physical features of the physical object based on the mesh projection.

Abstract: Example implementations also include a method of generating a diagnostic model and user interface presentation based on individual anatomical features, by generating a distance associated with a subset of anatomical features, characterizing the anatomical features based on one or more feature metrics, generating one or more diagnostic language objects based on one or more diagnostic language metrics, segmenting one or more of the anatomical features based on a diagnostic template, embedding one or more of the segments anatomical features in the diagnostic template, and modifying at least one of the diagnostic language objects, in response to a determination that the diagnostic language object is associated with a separate branch of the tree from another one of the diagnostic language objects.

Abstract: Example implementations include a method of mapping and segmenting a physical object by obtaining a plurality of two-dimensional images of a physical object, generating a three-dimensional object model of the physical object based at least partially on one or more of the two-dimensional images, obtaining a plurality of landmarks associated with the object model, one or more of the landmarks being respectively associated with corresponding three-dimensional coordinates and object plane identifiers, and generating at least one landmark plane at the object model including one or more of the landmarks including the object plane identifiers.

Abstract: In general, embodiments of the invention comprise systems and methods for performing image segmentation from image data. According to certain aspects, methods of the invention include constructing a fragment tree representation of image data. An image is segmented into regions of pixels having similar image characteristics, called fragments, each fragment (region) is then compared to its neighbors to determine a graph or hierarchical relationship among all regions. Groups of fragments can be selected by an operator or automatically to define a signature of an object. This signature can then be used to search or traverse a fragment tree any image in order to identify similar objects either automatically or manually.

Abstract: In general, embodiments of the invention comprise systems and methods for delineating objects from imaging scans. According to certain aspects, methods of the invention include aggregating homologous objects from multiple scans into categories, developing profiles or characteristics for these categories, matching newly identified objects to these pre-existing categories for object identification, and red-flagging, or visualization of identified objects.

Abstract: Systems and methods are described for positioning graphical objects and elements of graphical objects including widgets. At least two source layouts are selected, each source layout proportioning elements of the graphical object to be positioned. An interpolated layout is generated from the source layouts whereby the graphical object is positioned based on the interpolated layout. Multiple elements may be processed so. Elements of the graphical object can be proportioned differently from one another and the source layouts may be selected based on their relationship in size to the size of a desired runtime layout. The elements can include widget regions and content within the widget regions may be scaled independently of the positioning of the widget regions. The methods may be incorporated in a machine readable medium as data and executable instructions.

Abstract: Systems and methods for delineating anatomical boundaries from two- and three-dimensional image data are described. A template shape is used to examine new image element (e.g. pixel and/or voxel) locations and determine boundary intersection based on characteristics determined from the plurality of image elements contained within this template. The result is a polyline/surface delineation of the desired anatomy, which can be used for morphometric/shape analysis, patient specific output, and knowledge-based queries.

Abstract: Systems and methods for delineating anatomical boundaries from two- and three-dimensional image data are described. A template shape is used to examine new image element (e.g. pixel and/or voxel) locations and determine boundary intersection based on characteristics determined from the plurality of image elements contained within this template. The result is a polyline/surface delineation of the desired anatomy, which can be used for morphometric/shape analysis, patient specific output, and knowledge-based queries.

Abstract: Systems and methods are described for positioning graphical objects and elements of graphical objects including widgets. At least two source layouts are selected, each source layout proportioning elements of the graphical object to be positioned. An interpolated layout is generated from the source layouts whereby the graphical object is positioned based on the interpolated layout. Multiple elements may be processed so. Elements of the graphical object can be proportioned differently from one another and the source layouts may be selected based on their relationship in size to the size of a desired runtime layout. The elements can include widget regions and content within the widget regions may be scaled independently of the positioning of the widget regions. The methods may be incorporated in a machine readable medium as data and executable instructions.

Abstract: A process is described for efficiently recovering at least one of phytosterols and tocopherols in substantially pure form from the deodorizer distillates that may be obtained as by-products of the refining of edible oils. The phytosterol fatty acid esters present in deodorizer distillate are saponified with potassium hydroxide in a solvent medium containing methanol and water, thereby forming a solvent medium containing methanol, water, and the potassium soaps of fatty acids. Unsaponiable matter including tocopherols remain dissolved in this medium, allowing recovery of substantially pure phytosterols. Tocopherols in substantially pure form may be recovered by distillation under reduced pressure.

Abstract: A process for the synthesis and isolation of phytosterol esters is described, wherein an alkali metal borohydride is used to reductively bleach tocoquinones and other chromophores in phytosterol ester trans-esterification reaction mixtures. Phytosterol esters produced by this method possess the traditional hallmarks of quality, namely bland taste and light color, and are suitable for food and pharmaceutical applications.

Abstract: Tri- and tetra-substituted ethynylsilanes wherein the substituents are higher homologs of acetylene (e.g., substituted-ethynyl moieties having 3 to 10 carbon atoms) are described, Alkynylsilanes and, more particularly, high energy fuels and rocket propellants containing an alkynylsilane are also provided.

Abstract: The multi-pass sorting machine of this disclosure includes a supporting structure which has the configuration of an A-Frame. The A-Frame structure has a slanting front side supporting several individually functional devices and a slanting back side supporting other individually functional devices. The devices of the front side include an input feeding means, a first transporting means, a singulating means, an accelerating means, a second transporting means, a bar code reader and associated electronic and computer means, a plurality of first sorting means in the form of diverting vanes, an equal number of first pass stacker buffer means, and a reversing member for transporting letters from the front side to the back side while at the same time retaining the same orientation of the letters to the planar surface as the letters go around the corner.

Abstract: A multi-pass sorting machine includes a housing or supporting structure which has the configuration of an A-Frame. The A-Frame structure has a slanting front side supporting several individually functional devices and a slanting back side supporting other individually functional devices. The devices of the front side include an input feeder first transporting mechanisms, a singulating device, an accelerating mechanism, second transporting mechanisms, a bar code reader and associated electronic and computer equipment, a plurality of first sorting devices in the form of diverting vanes, an equal number of first pass stacker buffers, and a reversing member for transporting letters from the front side to the back side while at the same time retaining the same orientation of the letters to the planar surface as the letters go around the corner.

Abstract: A speed control system for an envelope feeding mechanism used to feed envelopes to a pickoff device in a high speed mail sorting machine. The feeding mechanism includes a pair of toothed belts which convey the envelopes along an inclined surface. The side edges of the envelopes are received by a third toothed belt which is driven at an elevated position along a side panel. The belts are driven by a multiple speed electric motor controlled by electronic circuitry which automatically decrements or increments the motor speed if the envelopes are bunched together too tightly or too loosely. If the speed is decremented and the envelopes are still tightly bunched, the drive motor is stopped by a shutoff circuit which operates independently of the speed control circuit.

Abstract: An alternator circuit comprises an alternator having an armature winding, a field winding, a voltage regulator, a fault detecting circuit, a lamp drive circuit having its input connected to the output of the fault detecting circuit, and a warning lamp driven by the drive circuit. The drive circuit includes a capacitor connected across its input, an input transistor, an output transistor, a current measuring resistor connected in series with the output transistor, and a transistor sensitive to both the voltage drop across the warning lamp and the voltage drop in the current measuring resistor. In the event of excessive current flow through the output transistor, the voltage sensitive transistor rapidly charges the capacitor thereby turning off the output transistor. The capacitor then discharges slowly and the cycle is repeated.