Patents by Inventor David William Holden

David William Holden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9789667
    Abstract: Fire resistant glazings comprise a fire resistant interlayer based upon a silicate waterglass are characterized by the incorporation of aluminum ions. The aluminate is incorporated as a solution which has been partially neutralized using hydroxycarboxylic acid which is preferably citric acid. The incorporation of aluminum provides glazings have improved fire resistance and impact properties.
    Type: Grant
    Filed: September 1, 2009
    Date of Patent: October 17, 2017
    Assignee: PILKINGTON PLC
    Inventors: Karikath Sukumar Varma, John Richard Holland, David William Holden, Stephen Ian Bond
  • Patent number: 9346962
    Abstract: An aqueous mixture for the production of fire resistant glazings comprising: at least one alkali metal silicate, at least one glass, glass-ceramic and/or ceramic additive, and water, wherein the at least one glass, glass-ceramic and/or ceramic additive has at least one boron containing moiety directly or indirectly attached to a surface thereof by covalent or ionic bonding.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: May 24, 2016
    Assignee: Pilkington Group Limited
    Inventors: David William Holden, Stephen Ian Bond, Karikath Sukumar Varma
  • Patent number: 9109164
    Abstract: A transparent fire resistant glazing comprising an intumescent interlayer, wherein the intumescent interlayer comprises an alkali metal silicate and a foam improvement additive, wherein the foam improvement additive comprises a polymer and/or oligomer and/or salts thereof, wherein said polymer, oligomer and/or salts thereof each contain at least one organic moiety having at least one hydrogen-bondable functional group covalently attached thereto.
    Type: Grant
    Filed: October 12, 2010
    Date of Patent: August 18, 2015
    Assignee: Pilkington Group Limited
    Inventors: Angela Yuk Fungt Cheung, Karikath Sukumar Varma, David William Holden, John Richard Holland, Stephen Ian Bond
  • Publication number: 20150056456
    Abstract: An aqueous mixture for the production of fire resistant glazings comprising: at least one alkali metal silicate, at least one glass, glass-ceramic and/or ceramic additive, and water, wherein the at least one glass, glass-ceramic and/or ceramic additive has at least one boron containing moiety directly or indirectly attached to a surface thereof by covalent or ionic bonding.
    Type: Application
    Filed: February 27, 2013
    Publication date: February 26, 2015
    Applicant: PILKINGTON GROUP LIMITED
    Inventors: David William Holden, Stephen Ian Bond, Karikath Sukumar Varma
  • Publication number: 20120292824
    Abstract: Bilayer materials are produced by drying a solution of an alkali metal silicate upon the surface of a flexible backing material until a flexible silicate film is produced. The film may be separated from the backing material and incorporated into laminated fire resistant glazings. The alkali metal silicate solution preferably comprise a surfactant. The bilayers may be transported or stored before the flexible silicate film is separated and incorporated into a glazing.
    Type: Application
    Filed: August 6, 2012
    Publication date: November 22, 2012
    Applicant: PILKINGTON PLC
    Inventors: Karikath Sukumar Varma, John Richard Holland, David William Holden, Stephen Ian Bond, Allan Stuart Dale
  • Publication number: 20120205600
    Abstract: A stable aqueous solution for the production of fire resistant glazings comprising: at least one alkali metal silicate; and an aqueous solution of at least one alkali-soluble anion of an acidic or amphoteric oxide and/or a complex thereof; and/or at least one alkali-soluble hydroxide, and/or alkali-soluble complex of elements selected from the group consisting of lithium, magnesium and calcium.
    Type: Application
    Filed: September 3, 2010
    Publication date: August 16, 2012
    Applicant: PILKINGTON GROUP LIMITED
    Inventors: David William Holden, John Richard Holland, Karikath Sukumar Varma, Stephen Ian Bond
  • Publication number: 20120208921
    Abstract: A transparent fire resistant glazing comprising an intumescent interlayer, wherein the intumescent interlayer comprises an alkali metal silicate and a foam improvement additive, wherein the foam improvement additive comprises a polymer and/or oligomer and/or salts thereof, wherein said polymer, oligomer and/or salts thereof each contain at least one organic moiety having at least one hydrogen-bondable functional group covalently attached thereto.
    Type: Application
    Filed: October 12, 2010
    Publication date: August 16, 2012
    Applicant: PILKINGTON GROUP LIMITED
    Inventors: Angela Yuk Fungt Cheung, Karikath Sukumar Varma, David William Holden, John Richard Holland, Stephen Ian Bond
  • Publication number: 20120076966
    Abstract: A fire-resistant laminated glazing comprising at least two glazing panes and at least one transparent intumescent interlayer between the glazing panes, said glazing panes being separated by a spacer extending at least partially around their peripheries so as to define a cavity to contain said interlayer, wherein the spacer comprises a shim for controlling the separation between the glazing panes to a predetermined distance and a rubber portion at least partially enclosing the shim, and wherein the interlayer comprises an alkali metal silicate.
    Type: Application
    Filed: May 18, 2010
    Publication date: March 29, 2012
    Applicant: PILKINGTON GROUP LIMITED
    Inventors: John Richard Holland, David William Holden, Heinz Wilhelm Holscher
  • Publication number: 20110229515
    Abstract: A method for identifying a microorganism having a reduced adaptation to a particular environment comprising the steps of: (1) providing a plurality of microorganisms each of which is independently mutated by the insertional inactivation of a gene with a nucleic acid comprising a unique marker sequence so that each mutant contains a different marker sequence, or clones of the said microorganism; (2) providing individually a stored sample of each mutant produced by step (1) and providing individually stored nucleic acid comprising the unique marker sequence from each individual mutant; (3) introducing a plurality of mutants produced by step (1) into the said particular environment and allowing those microorganisms which are able to do so to grow in the said environment; (4) retrieving microorganisms from the said environment or a selected part thereof and isolating the nucleic acid from the retrieved microorganisms; (5) comparing any marker sequences in the nucleic acid isolated in step (4) to the unique mar
    Type: Application
    Filed: September 27, 2010
    Publication date: September 22, 2011
    Inventor: David William HOLDEN
  • Patent number: 7955600
    Abstract: The present invention relates to vaccines, in particular, to an attenuated gram-negative cell comprising the SPI2 gene locus, wherein at least one gene of the SPI2 locus is inactivated, wherein said inactivation results in an attenuation/reduction of virulence compared to the wild type of said cell, and to a carrier for the presentation of an antigen to a host, which carrier is said attenuated gram-negative cell, wherein said cell comprises at least one heterologous nucleic acid molecule comprising a nucleic acid sequence coding for said antigen, wherein said cell is capable of expressing said nucleic acid molecule or capable of causing the expression of said nucleic acid molecule in a target cell.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: June 7, 2011
    Assignee: Emergent Product Development UK Limited
    Inventors: Michael Hensel, David William Holden, Jacqueline Elizabeth Shea
  • Patent number: 7947384
    Abstract: Solutions comprising a sodium silicate waterglass having a modulus of less than 3 and at least 8% by weight of an organic polyhydroxy compound such as glycerol are useful in the production of interlayers used in fire resistant glass laminates. The solutions are dried on a flat surface such as glass to produce a clear intumescent interlayer having improved impact resistance. The dried interlayer may be removed from the surface in the form of an elastomeric material which may also be used as an interlayer in a fire resistant glazing.
    Type: Grant
    Filed: October 5, 2006
    Date of Patent: May 24, 2011
    Assignee: Pilkington PLC
    Inventors: John Richard Holland, Karikath Sukumar Varma, David William Holden
  • Patent number: 7887816
    Abstract: The present invention pertains to a Salmonella microorganism having an attenuating mutation which disrupts the expression of a gene located within the Spi2 pathogenicity island, and an auxotrophic mutation. The microorganism therefore has a double mutation which helps prevent reactivity of the microorganism while maintaining the effectiveness of the microorganism to elicit an immune response. The present invention also pertains to vaccine compositions and methods for treating and preventing a Salmonella infection in a patient.
    Type: Grant
    Filed: February 1, 2007
    Date of Patent: February 15, 2011
    Assignee: Emergent Product Development UK Limited
    Inventors: Robert Graham Feldman, Gordon Dougan, Joseph David Santangelo, David William Holden, Jacqueline Elizabeth Shea, Zoe Hindle
  • Patent number: 7842290
    Abstract: A method for identifying a microorganism having a reduced adaptation to a particular environment comprising the steps of: (1) providing a plurality of microorganisms each of which is independently mutated by the insertional inactivation of a gene with a nucleic acid comprising a unique marker sequence so that each mutant contains a different marker sequence, or clones of the said microorganism; (2) providing individually a stored sample of each mutant produced by step (1) and providing individually stored nucleic acid comprising the unique marker sequence from each individual mutant; (3) introducing a plurality of mutants produced by step (1) into the said particular environment and allowing those microorganisms which are able to do so to grow in the said environment; (4) retrieving microorganisms from the said environment or a selected part thereof and isolating the nucleic acid from the retrieved microorganisms; (5) comparing any marker sequences in the nucleic acid isolated in step (4) to the unique mar
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: November 30, 2010
    Assignee: Emergent Product Development UK Limited
    Inventor: David William Holden
  • Patent number: 7700104
    Abstract: The present invention relates to vaccines, in particular, to an attenuated gram-negative cell comprising the SPI2 gene locus, wherein at least one gene of the SPI2 locus is inactivated, wherein said inactivation results in an attenuation/reduction of virulence compared to the wild type of said cell, and to a carrier for the presentation of an antigen to a host, which carrier is said attenuated gram-negative cell, wherein said cell comprises at least one heterologous nucleic acid molecule comprising a nucleic acid sequence coding for said antigen, wherein said cell is capable of expressing said nucleic acid molecule or capable of causing the expression of said nucleic acid molecule in a target cell.
    Type: Grant
    Filed: January 23, 2004
    Date of Patent: April 20, 2010
    Assignee: Emergent Product Development UK Limited
    Inventors: Michael Hensel, David William Holden, Jacqueline Elizabeth Shea
  • Publication number: 20090317618
    Abstract: Fire resistant glazings comprise a fire resistant interlayer based upon a silicate waterglass are characterised by the incorporation of aluminium ions. The aluminate is incorporated as a solution which has been partially neutralised using hydroxycarboxylic acid which is preferably citric acid. The incorporation of aluminium provides glazings have improved fire resistance and impact properties.
    Type: Application
    Filed: September 1, 2009
    Publication date: December 24, 2009
    Inventors: Karikath Sukumar Varma, John Richard Holland, David William Holden, Stephen Ian Bond
  • Publication number: 20090280141
    Abstract: Peptides derived from S. pneumoniae are identified as virulence determinants and may be useful in the preparation of vaccines for the treatment of infection. The peptides may be used as antigens or in the preparation of attenuated microorganisms for use as live oral vaccines.
    Type: Application
    Filed: November 16, 2007
    Publication date: November 12, 2009
    Applicant: Imperial College Innovations Limited
    Inventors: David William Holden, Jeremy Stuart Brown
  • Publication number: 20080274139
    Abstract: The present invention pertains to a Salmonella microorganism having an attenuating mutation which disrupts the expression of a gene located within the Spi2 pathogenicity island, and an auxotrophic mutation. The microorganism therefore has a double mutation which helps prevent reactivity of the microorganism while maintaining the effectiveness of the microorganism to elicit an immune response. The present invention also pertains to vaccine compositions and methods for treating and preventing a Salmonella infection in a patient.
    Type: Application
    Filed: February 1, 2007
    Publication date: November 6, 2008
    Inventors: Robert Graham Feldman, Gordon Dougan, Joseph David Santangelo, David William Holden, Jacqueline Elizabeth Shea, Zoe Hindle
  • Publication number: 20080175866
    Abstract: A method for identifying a microorganism having a reduced adaptation to a particular environment comprising the steps of: (1) providing a plurality of microorganisms each of which is independently mutated by the insertional inactivation of a gene with a nucleic acid comprising a unique marker sequence so that each mutant contains a different marker sequence, or clones of the said microorganism; (2) providing individually a stored sample of each mutant produced by step (1) and providing individually stored nucleic acid comprising the unique marker sequence from each individual mutant; (3) introducing a plurality of mutants produced by step (1) into the said particular environment and allowing those microorganisms which are able to do so to grow in the said environment; (4) retrieving microorganisms from the said environment or a selected part thereof and isolating the nucleic acid from the retrieved microorganisms; (5) comparing any marker sequences in the nucleic acid isolated in step (4) to the unique mar
    Type: Application
    Filed: August 17, 2007
    Publication date: July 24, 2008
    Applicants: Imperial College Innovations Limited, Microscience Limited
    Inventor: David William Holden
  • Patent number: 7334435
    Abstract: Process for the production of an intumescent fire resistant layer by drying a waterglass solution on the surface of a glass substrate are carried out in the presence of a salt of a carbonic acid or an ?-hydroxy carboxylic acid such as potassium citrate. The drying is preferably carried out at a rate which reduces of pH of the solution by no more than 2 units during an initial drying period of 5 hours. The resulting interlayers provide improved fire resistance.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: February 26, 2008
    Assignee: Pilkington plc
    Inventors: Karikath Sukumar Varma, John Richard Holland, David William Holden
  • Patent number: 7282092
    Abstract: Novel waterglass compositions comprise a zirconium containing anionic aggregate, preferably potassium zirconium carbonate or ammonium zirconium carbonate, in a quantity sufficient to provide at least 0.5% as zirconium metal. The compositions can be dried and/or gelled to form optically clear interlayers useful in the production of fire resistant glass laminates. The incorporation of the zirconium containing aggregate improves the fire resistant performance of the laminates.
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: October 16, 2007
    Assignee: Pilkington PLC
    Inventors: John Richard Holland, Karikath Sukumar Varma, David William Holden