Abstract: The present invention relates to methods of dispersing biofilms comprising Gram-negative bacteria, the methods comprising exposing the biofilm to an epoxytiglienone compound or a salt thereof. Methods of treating infections comprising the localised administration, for example, topically or by injection, of an epoxytiglienone compound into or onto an established biofilm comprising Gram-negative bacteria to disrupt the structure of that biofilm and methods of preventing biofilms comprising Gram-negative bacteria forming or dispersing biofilms comprising Gram-negative biofilms that have formed on medical devices are also described.

Abstract: The present invention relates to methods of dispersing biofilms comprising Gram-negative bacteria, the methods comprising exposing the biofilm to an epoxytiglienone compound or a salt thereof. Methods of treating infections comprising the localised administration, for example, topically or by injection, of an epoxytiglienone compound into or onto an established biofilm comprising Gram-negative bacteria to disrupt the structure of that biofilm and methods of preventing biofilms comprising Gram-negative bacteria forming or dispersing biofilms comprising Gram-negative biofilms that have formed on medical devices are also described.

Abstract: A bacitracin-alginate oligomer conjugate including a bacitracin-class antibiotic connected covalently to at least one alginate oligomer via a direct covalent bond or a covalent molecular linker, or a pharmaceutically acceptable salt, solvate, hydrate, diastereoisomer, tautomer, enantiomer or active metabolite thereof. Also provided are methods for the preparation of the conjugate, pharmaceutical compositions comprising the conjugate and the use thereof in a method for the treatment or prevention of a bacterial infection in a subject with, suspected to have, or at risk of, a bacterial infection.

Abstract: The present invention relates to methods of dispersing biofilms comprising Gram-negative bacteria, the methods comprising exposing the biofilm to an epoxytiglienone compound or a salt thereof. Methods of treating infections comprising the localised administration, for example, topically or by injection, of an epoxytiglienone compound into or onto an established biofilm comprising Gram-negative bacteria to disrupt the structure of that biofilm and methods of preventing biofilms comprising Gram-negative bacteria forming or dispersing biofilms comprising Gram-negative biofilms that have formed on medical devices are also described.

Abstract: A polymyxin-alginate oligomer conjugate including a polymyxin-class antibiotic connected covalently to at least one alginate oligomer via a direct covalent bond or a covalent molecular linker, or a pharmaceutically acceptable salt, solvate, hydrate, diastereoisomer, tautomer, enantiomer or active metabolite thereof. Also provided are methods for the preparation of the conjugate, pharmaceutical compositions comprising the conjugate and the use thereof in a method for the treatment or prevention of a bacterial infection in a subject with, suspected to have, or at risk of, a bacterial infection.

Abstract: The disclosure relates to use of alginate oligomers to enhance the effects of antifungal agents. The invention provides a method to improve the efficacy of an antifungal agent against a fungus, said method comprising using said antifungal agent together with an alginate oligomer. The fungus may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides an alginate oligomer for use together with at least one antifungal agent in treating a subject infected, suspected to be infected, or at risk of infection, with a fungus. In another aspect the method can be used to combat fungal contamination of a site e.g., for disinfection and cleaning purposes.

Abstract: A system and method for acquiring electronic data records is provided. A visual artifact encoded with content for acquiring an electronic data record associated with dynamic content is acquired at a portable electronic device. The visual artifact is processed to determine the content. The electronic data record is retrieved from a remote server via a network connection by processing the content at the portable electronic device.

Abstract: A system and method for management of electronic wallet databases is provided. In one embodiment portable electronic devices are deployed having a universal wallet application and a wallet data file associated with the application. The wallet data file is configured to maintain a plurality of different types of wallet artifacts in the form of data records. Dynamic content in association with each data record can be generated as each data record is accessed.

Abstract: A cutting apparatus comprises a machine bed support (1) having a quarter circle profile as seen from above and carrying a workpiece supporting platform (5). The workpiece may be a steel plate (6). The rear of the apparatus has an upstanding post (2) forming a vertical pivot to which is rigidly connected upper and lower arms (3) and (4) which may thus swing in a horizontal plane. A frame (7) is supported on the arms (3) and (4) by rollers R for free movement towards and away from the post (2). The lower limb of frame (7) carries the workpiece cutting device (16) and the upper limb of this frame caries a template following sensor device (8). The sensor device (8) is arranged to follow the required profile defined by a drawing or template on table (10) and this is effected by control of two drive motors using photo-electric template following means one motor driving a wheel (12) which frictionally engages the template and the other motor controlling the orientation of the wheel (12).