Abstract: Systems and methods are described herein to implement transverse momentum injection at low frequencies to directly modify large-scale eddies in a turbulent boundary layer on a surface of an object. A set of transverse momentum injection actuators may be positioned on the surface of the object to affect large-scale eddies in the turbulent boundary layer. The system may include a controller to selectively actuate the transverse momentum injection actuators with an actuation pattern to affect the large-scale eddies to modify the drag, fluid mixing, heat transfer, and/or other interactions of the fluid flow with the surface. In various embodiments, the transverse momentum injection actuators may be operated at frequencies less than 10,000 Hertz.

Abstract: Immunotherapeutic proteins comprising at least one heavy chain polypeptide derived from an IgG2 antibody are disclosed, wherein the heavy chain polypeptide comprises at least constant heavy domains 2 and 3 (CH2 and CH3) and the lower hinge, and the sequence of the lower hinge comprises a mutation enabling the immunotherapeutic protein to bind to and/or activate Fc?RIIb. The immunotherapeutic protein is suitable for use in methods of treating diseases or conditions wherein, for example, the activation of Fc?RIIb (ie for recruitment of the inhibitory functions of Fc?RIIb) is beneficial, such as allergic diseases.

Abstract: Systems and methods are described herein to implement transverse momentum injection at low frequencies to directly modify large-scale eddies in a turbulent boundary layer on a surface of an object. A set of transverse momentum injection actuators may be positioned on the surface of the object to affect large-scale eddies in the turbulent boundary layer. The system may include a controller to selectively actuate the transverse momentum injection actuators with an actuation pattern to affect the large-scale eddies to modify the drag, fluid mixing, heat transfer, and/or other interactions of the fluid flow with the surface. In various embodiments, the transverse momentum injection actuators may be operated at frequencies less than 10,000 Hertz.

Abstract: Systems and methods are described herein to implement transverse momentum injection at low frequencies to directly modify large-scale eddies in a turbulent boundary layer on a surface of an object. A set of transverse momentum injection actuators may be positioned on the surface of the object to affect large-scale eddies in the turbulent boundary layer. The system may include a controller to selectively actuate the transverse momentum injection actuators with an actuation pattern to affect the large-scale eddies to modify the drag of the fluid flow on the surface. In various embodiments, the transverse momentum injection actuators may be operated at frequencies less than 10,000 Hertz.

Abstract: Systems and methods are described herein to implement transverse momentum injection at low frequencies to directly modify large-scale eddies in a turbulent boundary layer on a surface of an object. A set of transverse momentum injection actuators may be positioned on the surface of the object to affect large-scale eddies in the turbulent boundary layer. The system may include a controller to selectively actuate the transverse momentum injection actuators with an actuation pattern to affect the large-scale eddies to modify the drag of the fluid flow on the surface. In various embodiments, the transverse momentum injection actuators may be operated at frequencies less than 10,000 Hertz.

Abstract: Systems and methods are described herein to implement transverse momentum injection at low frequencies to directly modify large-scale eddies in a turbulent boundary layer on a surface of an object. A set of transverse momentum injection actuators may be positioned on the surface of the object to affect large-scale eddies in the turbulent boundary layer. The system may include a controller to selectively actuate the transverse momentum injection actuators with an actuation pattern to affect the large-scale eddies to modify the drag of the fluid flow on the surface. In various embodiments, the transverse momentum injection actuators may be operated at frequencies less than 10,000 Hertz.

Abstract: Systems and methods are described herein to implement transverse momentum injection at low frequencies to directly modify large-scale eddies in a turbulent boundary layer on a surface of an object. A set of transverse momentum injection actuators may be positioned on the surface of the object to affect large-scale eddies in the turbulent boundary layer. The system may include a controller to selectively actuate the transverse momentum injection actuators with an actuation pattern to affect the large-scale eddies to modify the drag of the fluid flow on the surface. In various embodiments, the transverse momentum injection actuators may be operated at frequencies less than 10,000 Hertz.

Abstract: According to embodiments of the present invention, a method of additive manufacturing of an object using object material is provided. The method includes forming the object by processing some of the object material, and forming an object identifier by forming a pattern having at least one coded volume within an internal volume of the object, each of the at least one coded volume enclosing unprocessed object material. According to further embodiments of the present invention, an object manufactured using the method of additive manufacturing and a method of scanning an object identifier formed using the method of additive manufacturing are is also provided.

Abstract: The present disclosure relates to the use of an at least one soluble Fc binding multimer comprising at least two Fc binding regions to assess FcR binding activity of an at least one polypeptide comprising an Fc region or fragment thereof, including an antibody, and methods and assays of using the Fc binding multimer to assess FcR binding activity. The FcR binding multimer may be a fusion polypeptide comprising an at least two Fc binding regions, or may consist of at least two peptides each comprising at least one Fc binding region, that are covalently or non-covalently oligomerised.

Abstract: Methods, techniques, and systems for the live presentation of products and services to potential consumers in a manner that levels the playing field for suppliers/providers of different sizes, capabilities and with differing resources are provided. Examples provide a Dynamic Product Presentation System (“DPPS”), which enables suppliers and/or vendors to advertise and place new or replacement products before consumers according in a new commerce stream and enables potential consumers to interact on a personalized level with products including goods and/or services that may interest them before they buy them, to engage specialized services, return or exchange goods or other things, be presented with products and/or services that are automatically targeted to their buying habits and predicted needs, etc., all in the comfort of their own residence or location without the inconveniences of traditional shopping models or online environments.

Abstract: Methods, systems, and techniques for building, maintaining, and/or renovating buildings using reconfigurable, intelligent, and/or communicating components and connectors are provided. These reconfigurable building components and connectors are configured to communicate with each other and with the internal structures and services of a building, using various protocols, for more efficient reconfiguration, management, and maintenance as well as safety. Examples provide a Building Configuration and Management System which provides a set of “smart” components, connectors, and protocols and a Building Control System that connects all internal building structures and services together in ways that allow them to communicate their location, state, and other information to each other and to other entities and to control them, potentially automatically. The BCMS facilitates, among other things, more efficient reconfiguration of these structures and services without demolition.

Abstract: A soluble multimeric protein or polypeptide is disclosed that is able to inhibit interaction of leukocyte Fc? receptors (Fc?R) and immunoglobulin G (IgG). The protein or polypeptide comprises two or more linked Fc binding regions, at least one of which is derived from an Fc?R type receptor and, particularly, Fc?RIIa. Also described are polynucleotide molecules encoding the protein or polypeptide and the use thereof in methods of treating a subject for an immune-complex (IC)-mediated inflammatory disease.

Abstract: A system may be configured to receive input indicating an operating condition associated with a vehicle. One or more environmental parameters of vehicle operation may be identified and compared with the operating condition to determine a safety rating of the vehicle operation based, at least in part, on the comparison. The safety rating may be assigned to an account associated with an operator of the vehicle.

Abstract: A soluble multimeric protein or polypeptide is disclosed that is able to inhibit interaction of leukocyte Fc? receptors (Fc?R) and immunoglobulin G (IgG). The protein or polypeptide comprises two or more linked Fc binding regions, at least one of which is derived from an Fc?R type receptor and, particularly, Fc?RIIa. Also described are polynucleotide molecules encoding the protein or polypeptide and the use thereof in methods of treating a subject for an immune-complex (IC)-mediated inflammatory disease.

Abstract: The invention disclosed herein relates to fuel cell electrode pair assemblies, not having interposing proton exchange membranes, configured to receive and react with liquid anolyte and liquid catholyte microfluidic flowstreams. In one embodiment, the present invention is directed to a fuel cell electrode pair assembly, not having an interposing proton exchange membrane, configured to receive and react with a liquid microfluidic anolyte flowstream (e.g., laminarly flowing methanol solution) and a liquid microfluidic catholyte flowstream (e.g., laminarly flowing nitric acid solution), wherein the fuel cell electrode pair assembly comprises: a porous flow-through anode; a porous flow-by cathode confronting and spaced apart from the anode; and a central plenum interposed between and connected to the anode and the cathode.

Abstract: The invention relates to SSL7 mutants which have no, or at least reduced, ability to bind to IgA. The mutants have significant application in the purification or isolation of C5 from samples and in the identification or detection, including quantitation, of C5 in samples. Use of the mutants has the benefit of minimising or preventing simultaneous isolation and/or detection of IgA in a sample, simplifying and improving methods relying on wild type SSL7.

Abstract: A soluble multimeric polypeptide or protein is disclosed that is able to inhibit interaction of leukocyte Fc? receptors (Fc?R) and immunoglobulin G (IgG). The protein or polypeptide comprises two or more Fc binding regions linked in a head to tail arrangement, at least one of which is derived from an Fc?R type receptor, and an Fc domain of an immunoglobulin which has been modified to reduce or prevent binding to the said Fc binding regions and/or to alter effector function. Also described are polynucleotide molecules encoding the polypeptide or protein and the use thereof in methods of treating a subject for an immune-complex (IC)-mediated inflammatory disease.

Abstract: The invention disclosed herein relates to fuel cell electrode pair assemblies, not having interposing proton exchange membranes, configured to receive and react with liquid anolyte and liquid catholyte microfluidic flowstreams. In one embodiment, the present invention is directed to a fuel cell electrode pair assembly, not having an interposing proton exchange membrane, configured to receive and react with a liquid microfluidic anolyte flowstream (e.g., laminarly flowing methanol solution) and a liquid microfluidic catholyte flowstream (e.g., laminarly flowing nitric acid solution), wherein the fuel cell electrode pair assembly comprises: a porous flow-through anode; a porous flow-by cathode confronting and spaced apart from the anode; and a central plenum interposed between and connected to the anode and the cathode.

Abstract: A MEM s scanning device has a variable resonant frequency. In one embodiment, the MEMs device includes a torsion arm that supports an oscillatory body. In one embodiment, an array of removable masses are placed on an exposed portion of the oscillatory body and selectively removed to establish the resonant frequency. The material can be removed by laser ablation, etching, or other processing approaches. In another approach, a migratory material is placed on the torsion arm and selectively stimulated to migrate into the torsion arm, thereby changing the mechanical properties of the torsion arm. The changed mechanical properties in turn changes the resonant frequency of the torsion arm. In another approach, symmetrically distributed masses are removed or added in response to a measured resonant frequency to tune the resonant frequency to a desired resonant frequency. A display apparatus includes the scanning device and the scanning device scans about two or more axes, typically in a raster pattern.

Abstract: A beam scanner is operable to scan light in two or more axes, typically in a raster pattern that includes a fast scan axis and a slow scan axis. Plural beams of light are scanned, each beam of light producing a scanned region that at least partially overlaps at least one adjoining scanned region. Scanned regions may be aligned to adjoin and overlap along a dimension corresponding to the slow scan axis. The beam scanner may comprise a scanned beam display and/or a scanned beam image capture device. In a display, the power level of overlapping displayed pixels may be scaled to provide smooth transitions between adjoining regions to improve the image quality presented to a viewer. In an image capture device, one or more detectors is operable to collect light scattered from adjoining regions and a controller is operable to produce an image from the scanned regions.