Abstract: Techniques for implementing and/or operating a pipe handling system that includes an inboard bore plug assembly and an outboard bore plug assembly, which facilitate plugging a pipe bore in a flexible pipe. The inboard bore plug assembly includes a first inflatable plug having a first inflatable bladder that defines a first fluid cavity and a first inflation port opening and a first inflation fluid port secured within the first inflation port opening. The outboard bore plug assembly includes a second inflatable plug having a second inflatable bladder that defines a second fluid cavity, a second inflation port opening, and a bore port opening, a second inflation fluid port secured within the second inflation port opening, and a bore fluid port secured in the bore port opening to enable the pipe bore in the flexible pipe to be pressurized to an elevated fluid pressure.

Abstract: Disclosed is a system and method for wirelessly monitoring 5 process conditions within a reactor vessel. A plurality of sensor-enabled radio frequency identification (RFID) tags are disposed at known locations throughout a catalyst bed of a vessel and are used to measure various conditions within the vessel. The sensor-enabled RFID tags are encoded with individual identification codes and are wirelessly linked to a transceiver. A transceiver 10 provides for the interrogation of each sensor-enabled RFID tag to receive responsive transponder signals that carry information representative of both the three-dimensional location of the sensor-enabled RFID tags and the sensed conditions within the reactor. This allows for three-dimensional profiling of the specifically measured condition within the reactor.

Abstract: Disclosed is a system and method for wirelessly monitoring process conditions within a reactor vessel. An array of sensor-enabled radio frequency identification (RFID) tags is placed at known heights within a catalyst bed of a vessel and are used to measure 10 various conditions within the vessel. The sensor-enabled RFID tags are encoded with individual identification codes and are wirelessly linked to multiple transceivers. The use of multiple transceivers allows for the application of triangulation methods to identify the location of each of the sensor-enabled RFID tags in three-dimensional space and for the interrogation of each sensor-enabled RFID tag to receive responsive transponder signals that carry information representative of the sensed condition within the reactor.

Abstract: Disclosed is a system and method for wirelessly monitoring process conditions within a reactor vessel. An array of sensor-enabled radio frequency identification (RFID) tags is placed at known heights within a catalyst bed of a vessel and are used to measure 10 various conditions within the vessel. The sensor-enabled RFID tags are encoded with individual identification codes and are wirelessly linked to multiple transceivers. The use of multiple transceivers allows for the application of triangulation methods to identify the location of each of the sensor-enabled RFID tags in three-dimensional space and for the interrogation of each sensor-enabled RFID tag to receive responsive transponder signals that carry information representative of the sensed condition within the reactor.

Abstract: Disclosed is a system and method for wirelessly monitoring 5 process conditions within a reactor vessel. A plurality of sensor-enabled radio frequency identification (RFID) tags are disposed at known locations throughout a catalyst bed of a vessel and are used to measure various conditions within the vessel. The sensor-enabled RFID tags are encoded with individual identification codes and are wirelessly linked to a transceiver. A transceiver 10 provides for the interrogation of each sensor-enabled RFID tag to receive responsive transponder signals that carry information representative of both the three-dimensional location of the sensor-enabled RFID tags and the sensed conditions within the reactor. This allows for three-dimensional profiling of the specifically measured condition within the reactor.

Abstract: A stand-alone web-based rapid anatomical documentation (RAD) system searches for ICD codes linked to key words that are applied to a standards-based structured vocabulary. The RAD system provides a search screen divided into a plurality of display regions for selecting a search type from the search screen. The search type includes a text search and anatomy search. Based on the type of search initialed, search filters and ICD codes are made available. Selecting at least one search filter causes an update of the search filters and ICD codes available, wherein the selection of the search filters can be repeated until a number of codes available reach a minimum value. Each ICD code is linked to keywords hierarchically organized and associated with the search filters, links to defined regions on anatomical art images and clinically relevant information.

Abstract: The present invention provides compositions and methods for assessing profiles of catalytically active enzymes in compositions containing a plurality of proteins. In preferred embodiments, the enzyme is a hydrolase, most preferably a cysteine protease. The methods described herein use activity based probes (“ABPs”) that have an affinity moiety for directing the binding of the ABP to one or more catalytically active target enzymes, a reactive group for forming a covalent bond at an active site of the target enzyme(s), and a TAG (e.g., a detectable label, preferably a fluorophore). One or more ABPs may be combined with a protein-containing sample under conditions for binding and reaction of the ABP(s) with target enzyme(s) that are present in the sample. The resulting products may then be used to assess the active enzyme profile of the sample, and can be correlated to the presence, amount, or activity of one or more target enzyme(s) present in the original complex protein mixture.

Abstract: A dispersion comprising a discontinuous phase of solid particles or liquid droplets in a liquid continuous phase; a polymeric dispersant having a segment soluble in the continuous phase and a segment insoluble in the continuous phase; and a network around the solid particles or liquid droplets of the discontinuous phase formed by cross-linking of the polymeric dispersant; where the cross-linking is between segments that are soluble in the continuous phase.

Abstract: The present invention is directed to a method of treatment of a malcondition that can be regulated or normalized via inhibition of DPP-IV. The method involves administration of an effective amount of a pyrrolidine compound of the invention, such as would be present in a pharmaceutical composition of the invention, to mammals, especially humans, to affect a malcondition that can be regulated or normalized via inhibition of DPP-IV.

Abstract: A transmissive display system is calibrated by applying DAC values for a target color and noting the color displayed on the screen. The displayed color is compared to the target color in high and low ambient light levels to determine if it is within a specified tolerance of the target color. Should the displayed color not be within the tolerance range, a calibration procedure is launched for both the high and low light levels which establishes new DAC values and backlight levels for accurate target color presentation on the screen over a wide dynamic range of input signal levels.

Abstract: Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I: wherein n is 1 to 3; X is CH2; S; O; CF2 or C(CH3)2; Z is H; halogen; hydroxyl; (C1-6)alkoxy; (C1-12)alkyl; (C3-12)cycloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are optionally mono- or independently plurisubstituted with R7; optionally, X together with an adjacent ring carbon and Z form a fused cyclopropyl; and optionally, one of the bonds in the ring containing X is a double bond; and CRiRii, R1, R2, R3, R4 and R5 are as described herein.

Abstract: The present invention provides compositions and methods for assessing profiles of catalytically active enzymes in compositions containing a plurality of proteins. In preferred embodiments, the enzyme is a hydrolase, most preferably a cysteine protease. The methods described herein use activity based probes (“ABPs”) that have an affinity moiety for directing the binding of the ABP to one or more catalytically active target enzymes, a reactive group for forming a covalent bond at an active site of the target enzyme(s), and a TAG (e.g., a detectable label, preferably a fluorophore). One or more ABPs may be combined with a protein-containing sample under conditions for binding and reaction of the ABP(s) with target enzyme(s) that are present in the sample. The resulting products may then be used to assess the active enzyme profile of the sample, and can be correlated to the presence, amount, or activity of one or more target enzyme(s) present in the original complex protein mixture.

Abstract: Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I: wherein n is 1 to 3; X is CH2; S; O; CF2 or C(CH3)2; Z is H; halogen; hydroxyl; (C1-6)alkoxy; (C1-12)alkyl; (C3-12)cycloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are optionally mono- or independently plurisubstituted with R7; optionally, X together with an adjacent ring carbon and Z form a fused cyclopropyl; and optionally, one of the bonds in the ring containing X is a double bond; and CriRii, R1, R1, R3, R4 and R5 are as described herein. Methods for preparing these compounds, and methods for treating diabetes, especially Type II diabetes, and other related diseases are described using the compounds of formula I in pharmaceutical compositions which contain these compounds. Pharmaceutical compositions which contain combinations of these compounds with other antidiabetic agents are also described herein.

Abstract: Compounds that selectively inhibit dipeptidyl peptidase-IV over closely related dipeptidyl peptidases are those of Formula (I): as well as pharmaceutically acceptable salts thereof, cyclic isomers thereof, prodrugs thereof, and solvates thereof, where all the variables are defined herein. These compounds can be used, alone or in combination with other drugs, for the treatment of diabetes and related diseases.

Abstract: The present invention is directed to pyrrolidinylaminoacetyl pyrrolidine boronic acid compounds that display selective, potent dipeptidyl peptidase IV inhibitory activity. These compounds are useful for the treatment of disorders that can be regulated or normalized via inhibition of DPP-IV including those characterized by impaired glycemic control such as Diabetes Mellitus and related conditions. The compounds can be administered alone or with another medicament that displays pharmacological activity for treatment of these and other diseases.

Abstract: The present invention is directed to pyrrolidinylaminoacetyl pyrrolidine boronic acid compounds that display selective, potent dipeptidyl peptidase IV inhibitory activity. These compounds are useful for the treatment of disorders that can be regulated or normalized via inhibition of DPP-IV including those characterized by impaired glycemic control such as Diabetes Mellitus and related conditions. The compounds can be administered alone or with another medicament that displays pharmacological activity for treatment of these and other diseases.

Abstract: The present invention is directed to pyrrolidinylaminoacetyl pyrrolidine boronic acid compounds that display selective, potent dipeptidyl peptidase IV (DPP-IV) inhibitory activity. These compounds are useful for the treatment of disorders that can be regulated or normalized via inhibition of DPP-IV including those characterized by impaired glycemic control such as Diabetes Mellitus and related conditions. The compounds can be administered alone or with another medicament that displays pharmacological activity for treatment of these and other diseases.

Abstract: Certain constrained cyano compounds are useful as inhibitors of post-proline/alanine cleaving amino-dipeptidases. Accordingly, these compounds can be employed, alone or with another therapeutic agent, to treat diabetes (especially, Type II diabetes), hyperglycemia, Syndrome X, diabetic complications, hyperinsulinemia, obesity, atherosclerosis and related diseases, as well as various immunomodulatory diseases and chronic inflammatory bowel disease.

Abstract: Disclosed is a method and system for providing constant critical AC electrical load with primary, secondary, and in some cases a tertiary source of power with higher reliability and lower operating and capital costs and lower emissions than the traditional utility supply, uninterruptible power supply (UPS), and battery primary power source, and diesel generator back-up systems that are predominately used today. Specifically, the disclosed system utilizes on-site power generation to provide primary power and includes full utility and UPS/DC storage back-up systems.

Abstract: A spray hood device for containing a fluid spray leak in a fluid-based cooling system. A cover member surrounds a given component subject to a fluid spray leak, containing fluid sprays, preventing the fluid sprays from reaching equipment therebelow and minimizing fluid leakage damage.