Abstract: The present disclosure pertains to a method of diagnosing cancer and, in particular, to a method of diagnosing early-stage non-small cell lung cancer by measuring metabolite biomarkers in serum and plasma. In some aspects, the methods comprise determining the concentration metabolites from the group comprising ?-hydroxybutyric acid, LysoPC 20:3, PC ae C40:6, citric acid, carnitine, Sand fumaric acid. In some aspects, the methods comprise determining the concentration metabolites from the group comprising ?-hydroxybutyric acid, LysoPC 20:3, spermidine, and fumaric acid.

Abstract: The present disclosure relates to methods and kits for the diagnosis and treatment of autism spectrum disorder (ASD) in human subjects. The disclosure also relates to computer-implemented methods for diagnosing and treating ASD. Current diagnostic protocols are mainly limited to behavioural examination as laboratory findings have been consistently abnormal in ASD. No currently reported biomarker holds promise as early developmental screen or an early diagnostic or prognostic tool for pediatric settings at young ages from birth through early childhood when these clinical tools are most needed. With the present disclosure, metabolomic profiles, protein profiles and combinations thereof for ASD are identified in the subject having ASD.

Abstract: The present invention relates to methods of diagnosing acute rejection of a cardiac allograft using genomic expression profiling, proteomic expression profiling, metabolite profiling, or alloreactive T-cell genomic expression profiling,

Abstract: A computer implemented process for producing a representation of a reference spectrum for a reference solution having a first pH condition, for use in determining the composition of a test sample, is disclosed. The process involves producing a position value for at least one peak of the reference spectrum in response to a measured pH condition of the test sample, and a property of at least one peak in a base reference spectrum for the reference solution, the base reference spectrum being associated with a pH condition of the reference solution that is different from said measured pH condition.

Abstract: A process for quantitative and qualitative analysis for identifying compounds in a sample mixture involves the identification of a set of reference spectra selected according to a measured condition of the sample, which collectively define a composite spectrum which best matches a spectrum produced from the sample. The compounds associated with respective reference spectra of the identified set are the compounds that are determined to be likely to be present in the sample. Quantities of the compounds may be determined from the intensities of certain representative peaks associated with the compounds, relative to the intensity of a peak associated with a reference compound which is unaffected by the measured condition of the sample. A measured condition may be pH of the sample, for example, and an accurate measurement of pH can be obtained from the test spectrum. Thus, given a test spectrum of a sample and given a set of reference spectra, the process can identify and quantify compounds present in the sample.