Abstract: The present invention provides improved intravaginal drug delivery devices, i.e., intravaginal rings, useful for the prophylactic administration of an antimicrobial compound, e.g., Dapivirine, to a human. The intravaginal rings of the invention address previous stability issues by utilizing a platinum catalyst (e.g., in the form of a platinum-siloxane complex) for the cross-linking reaction. The vaginal rings surprisingly achieve relatively high and steady release rates in vivo with a matrix ring containing a relatively small loading dose. While the matrix rings of the present invention have in vivo the steady release rates associated with reservoir rings, they are easier and less expensive to manufacture. The present invention also provides methods of blocking DNA polymerization by an HIV reverse transcriptase enzyme, methods of preventing HIV infection in a female human, methods of treating HIV infection in a female human, and methods of preparing platinum-catalyzed intravaginal rings.

Abstract: The present invention provides improved intravaginal drug delivery devices, i.e., intravaginal rings, useful for the prophylactic administration of an antimicrobial compound, e.g., Dapivirine, to a human. The intravaginal rings of the invention address previous stability issues by utilizing a platinum catalyst (e.g., in the form of a platinum-siloxane complex) for the cross-linking reaction. The vaginal rings surprisingly achieve relatively high and steady release rates in vivo with a matrix ring containing a relatively small loading dose. While the matrix rings of the present invention have in vivo the steady release rates associated with reservoir rings, they are easier and less expensive to manufacture. The present invention also provides methods of blocking DNA polymerization by an HIV reverse transcriptase enzyme, methods of preventing HIV infection in a female human, methods of treating HIV infection in a female human, and methods of preparing platinum-catalyzed intravaginal rings.

Abstract: A hermetically sealed infection control bedding product such as a pillow, duvet, mattress, cushion or such like having a sealed cover and having a resiliently deformable filling material, comprising a vent means in the cover, characterized in that the vent means comprises a filter medium including a filter membrane for the removal of particles of microbial size and wherein the filter medium also comprises a strengthening layer of material for providing mechanical strength to the filter medium whereby the filter medium allows air flow therethrough but is substantially impermeable to liquid while maintaining a barrier to particles of microbial size.

Abstract: The present invention relates to microbial detection valves and particularly, unidirectional valves which include means for detecting the presence of microbes. The present invention also relates to infection control cushioning and/or bedding including said microbial detection valves. In another aspect, the present invention concerns improvements in and relating to hygienic bedding and particularly in and relating to hygienic bedding covers. The present invention has the advantage that it provides a one-way valve incorporated into the pillow cover as well as a microbial filter membrane, to allow air to exhaust quickly from the pillow through the valve, bypassing the membrane. Air re-entering the pillow may only pass through the microbial filter membrane. Thus, air re-entering the pillow does so at slower speed, but has the advantage that forcing the re-entering air to pass through the micorbial filter allows only sterile air to enter the pillow.

Abstract: The present invention provides improved intravaginal drug delivery devices, i.e., intravaginal rings, useful for the prophylactic administration of an antimicrobial compound, e.g., Dapivirine, to a human. The intravaginal rings of the invention address previous stability issues by utilizing a platinum catalyst (e.g., in the form of a platinum-siloxane complex) for the cross-linking reaction. The vaginal rings surprisingly achieve relatively high and steady release rates in vivo with a matrix ring containing a relatively small loading dose. While the matrix rings of the present invention have in vivo the steady release rates associated with reservoir rings, they are easier and less expensive to manufacture. The present invention also provides methods of blocking DNA polymerization by an HIV reverse transcriptase enzyme, methods of preventing HIV infection in a female human, methods of treating HIV infection in a female human, and methods of preparing platinum-catalyzed intravaginal rings.

Abstract: A mattress, cushion or the like has an outer cover enclosing a resilient core. The resilient core is formed by a viscoelastic foam layer with a vapour permeable reinforcing layer of stretchable material laminated onto a top surface of the viscoelastic foam layer. The reinforcing layer prevents cracking in the top surface of the viscoelastic foam layer and provides improved heat and moisture dissipation during use. The reinforcing layer is preferably formed by a spaced knitted fabric.

Abstract: The present invention relates to a moist, layered bioadhesive patch comprising one or more polymers. Moreover, the invention relates to a method of producing a monolayered film and a method of drying said film. Additionally, the invention relates to methods of producing bioadhesive, layered patches by combining layers of the monolayered film to obtain a desired thickness of the patch. Patches according to the invention may be used as such, or for delivering pharmaceutically active compounds, such as in a drug delivery system.

Abstract: A measuring device to aid mattress selection has an upstanding frame with a plurality of vertically space-apart horizontal illuminated strips. A camera mounted in front of the frame takes front view and side view images of a person standing in front of the illuminated strips. These images are delivered to an associated computer having means to determine the body mass distribution and the spine curvature of the person based on the images of the strips taken by the camera and in particular based on those portions of the image of the illuminated strips blocked by the person standing in front of the illuminated strips. This information can then be used to aid in appropriate mattress selection for the person.

Abstract: A hermetically sealed infection control bedding product such as a pillow, duvet, mattress, cushion or such like having a sealed cover and having a resiliently deformable filling material, comprising a vent means in the cover, characterised in that the vent means comprises a filter medium including a filter membrane for the removal of particles of microbial size and wherein the filter medium also comprises a strengthening layer of material for providing mechanical strength to the filter medium whereby the filter medium allows air flow therethrough but is substantially impermeable to liquid while maintaining a barrier to particles of microbial size.

Abstract: A microprotrusion array for use in transport of a material across a biological barrier, wherein said array comprises a plurality of microprotusions composed of a swellable polymer composition.

Abstract: A measuring device to aid mattress selection has an upstanding frame with a plurality of vertically space-apart horizontal illuminated strips. A camera mounted in front of the frame takes front view and side view images of a person standing in front of the illuminated strips. These images are delivered to an associated computer having means to determine the body mass distribution and the spine curvature of the person based on the images of the strips taken by the camera and in particular based on those portions of the image of the illuminated strips blocked by the person standing in front of the illuminated strips. This information can then be used to aid in appropriate mattress selection for the person.

Abstract: Pharmaceutical formulations containing tetracycline for topical administration, as well as methods of making and administering the same, are disclosed.

Abstract: Multi-part pharmaceutical formulations containing tetracycline for topical administration, as well as methods of making and administering the same, are disclosed.

Abstract: A mattress, cushion or the like has an outer cover enclosing a resilient core. The resilient core is formed by a viscoelastic foam layer with a vapour permeable reinforcing layer of stretchable material laminated onto a top surface of the viscoelastic foam layer. The reinforcing layer prevents cracking in the top surface of the viscoelastic foam layer and provides improved heat and moisture dissipation during use. The reinforcing layer is preferably formed by a spaced knitted fabric.

Abstract: Pharmaceutical gel compositions containing estrogen for vaginal administration, as well as a method of making the same, are disclosed.

Abstract: Pharmaceutical gel compositions containing estrogen for vaginal administration, as well as a method of making the same, are disclosed.

Abstract: Pharmaceutical gel compositions containing pharmacologically active agent for topical administration, as well as a method of making the same, are disclosed.

Abstract: A mattress comprises a sealed outer casing within which is mounted a resilient support formed by a composite foam core. At least an upper portion of the resilient support is formed by a visco-elastic foam. A vent is provided in a side wall of the casing and is covered by a filter which prevents ingress of bacteria into the cover. A flap is mounted on the cover and in use extends down over the vent to prevent the filter being damaged by fluids.

Abstract: An intravaginal antimicrobial drug delivery device is disclosed having an antimicrobial agent dispersed throughout a biocompatible elastomeric system. Also disclosed is a method of making the antimicrobial drug delivery device.

Abstract: A mattress comprises a sealed outer casing within which is mounted a resilient support formed by a composite foam core. At least an upper portion of the resilient support is formed by a visco-elastic foam. A vent is provided in a side wall of the casing and is covered by a filter which prevents ingress of bacteria into the cover. A flap is mounted on the cover and in use extends down over the vent to prevent the filter being damaged by fluids.