Abstract: A modified amyloid precursor protein can be expressed from a DNA construct comprising an APP DNA sequence, or a fragment or artificial substrate thereof, encoding the mutation I45W, I45Y V46W or V46Y (numbering relative to A4CT); the use of the DNA construct in the generation of cell lines or transgenic animals and the use of these proteins or such transgenic animals in the diagnosis of Alzheimer's Disease and screening putative drugs against Alzheimer's Disease are also described.

Abstract: Compounds of formula (I): are useful in the treatment of diseases associated with deposition of ?-amyloid in the brain.

Abstract: Polyetherester elastomers comprising about 25 to about 59 weight percent poly(trimethylene ether) ester soft segments and about 41 to about 75 weight percent hard segments, wherein the poly(trimethylene ether) ester soft segments are derived from poly(trimethylene ether) glycol having a number average molecular weight of about 600 to about 2500. Compositions thereof and articles made therefrom are disclosed.

Abstract: The present invention directly deals with the problem of cavitation corrosion by modifying the hub of a propeller to eliminate low pressure areas. The present invention is the placement, formation, and/or insertion, on a propeller, of a non-smooth area in each facet of the hub between each of the blades. This area is also sometimes referred to as the “blade root”. The exact configuration of the raised area can vary from a longitudinal raised area to single or multiple bumps or buttons to single or multiple pointed projections. By modifying the hub, whether by casting a new propeller with a redesigned hub, or by retrofitting an existing hub, the elimination of corrosion occurs when a high Developed Area Ratio (DAR) propeller hub has one or more raised protrusions on the surfaces of the propeller hub between each blade seat. The addition of the raised protrusions discourages the formation of low pressure areas around the hub.

Abstract: A woven fabric comprises cross-machine direction weft yarns, and an array of interwoven warp yarns, the warp yarns being woven in the machine direction in alternating groups of relatively narrow yarns and relatively wide yarns. The narrow yarns are looped around a respective last weft yarn and backwoven, whilst the wider yarns are extended to form interdigitable loops for engagement of a pintle wire.

Abstract: Apparatus (1) for treating a fluid, in this case wastewater, comprising a vessel or tank (2), a conduit (3) to supply the wastewater in an alternating sequence to the vessel (2), and a source (4) for oxygenating the bed of granular media (5) to provide aerated filter media. The filter bed is aerated during operation by air, oxygen enriched air or other gas being introduced at or adjacent the base (as viewed) of the bed through the source (4), which may be a perforated manifold, diffuser or the like extending substantially over the whole surface area of the bed (5). Also, the bed (5) is a granular media such as natural minerals or blast furnace slag media to the surface of the discrete particles of which is attached bacteria and microorganisms (a biomass) which effects treatment of the fluid.