Abstract: Data related to operational performance of a plurality of nodes in a system is obtained and a first metric anomaly associated with a node of the plurality of nodes in the system is identified. The first metric anomaly indicates that data associated with a first metric is outside a threshold range. Second metrics related to the first metric are identified and it is determined that one of the second metrics is an anomaly. Third metrics related to the second metric are identified and it is determined whether any third metric is an anomaly. The second metric is identified as a probable cause of the first metric anomaly when it is determined that no third metric is an anomaly. A report including information associated with the probable cause of the first metric anomaly is transmitted to a user device.

Abstract: Described are compositions and methods for preventing, treating or ameliorating an inflammation-mediated and/or complement-mediated disease or condition in a subject comprising administering to the subject a Fas inhibitor, its derivative, a pharmaceutically acceptable salt thereof, of a gene therapy encoding the Fas inhibitor in an amount effective to inhibit Fas signaling.

Abstract: Provided herein are compositions including peptides, pharmaceutical preparations thereof, and methods of preventing photoreceptor death therewith and protecting of retinal cells, including, but not limited to, photoreceptors and retinal pigment epithelium, from Fas- or TRAIL-mediated apoptosis. Also, described are compositions and methods for preventing, treating or ameliorating an inflammation-mediated and/or complement-mediated disease or condition in a subject comprising administering to the subject a Fas inhibitor, its derivative, a pharmaceutically acceptable salt thereof, of a gene therapy encoding the Fas inhibitor in an amount effective to inhibit Fas signaling.

Abstract: Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering an apoptosis inhibitor to a mammal having an eye with retinal detachment. The apoptosis inhibitor maintains the viability of the photoreceptor cells until such time that the retina becomes reattached to the underlying retinal pigment epithelium and choroid. The treatment minimizes the loss of vision, which otherwise may occur as a result of retinal detachment.

Abstract: Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering an apoptosis inhibitor to a mammal having an eye with retinal detachment. The apoptosis inhibitor maintains the viability of the photoreceptor cells until such time that the retina becomes reattached to the underlying retinal pigment epithelium and choroid. The treatment minimizes the loss of vision, which otherwise may occur as a result of retinal detachment.

Abstract: An InfraRed Suppression System (IRSS) includes an exhaust manifold and a high aspect ratio exhaust duct along a longitudinal length thereof. The IRSS minimizes impingement of engine exhaust onto adjacent aircraft structure by discharging the flow upwardly and/or outwardly, away from the fuselage at relatively high velocity to reduce fuselage heating due to plume impingement in both hover and forward flight thus minimizing fuselage IR signature contributions. Furthermore, by directing the exhaust stream upward, a direct line of sight to the exhausted IR energy is masked from ground threats. The high aspect ratio exhaust duct and exhaust manifold are also preferably shrouded by an aerodynamic fairing which provides an aerodynamic contour to minimize aerodynamic impact to the aircraft and defines an air-cooled ejector gap to augment airflow to further insulate and obscure the high temperature exhaust gas exhausted through the exhaust duct.

Abstract: Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering an apoptosis inhibitor to a mammal having an eye with retinal detachment. The apoptosis inhibitor maintains the viability of the photoreceptor cells until such time that the retina becomes reattached to the underlying retinal pigment epithelium and choroid. The treatment minimizes the loss of vision, which otherwise may occur as a result of retinal detachment.