Abstract: A leaflet restraint (20) includes a non-blood-occlusive net (30), which is configured to at least partially cover an atrial surface (32) of a single native cardiac leaflet (34) of a native atrioventricular valve (36) of a heart (38). Two or more tissue-penetrating annulus anchors (40) are fixed to an annular side (42) of the net (30), and are configured to be anchored to an annulus (44) of the native atrioventricular valve (36) along or within 1 cm of a portion of the annulus (44) to which the single native cardiac leaflet (34) attaches. A ventricular anchor (50) is configured to be anchored to a ventricle (54) of the heart (58) so as to anchor a ventricular end (52) of the net (30) to the ventricle (54). The leaflet restraint (20) is configured, when anchored in place at least partially covering the atrial surface (32) of the single native cardiac leaflet (34), to limit prolapse of the single native cardiac leaflet (34) into an atrium (56) of the heart (38). Other embodiments are also described.

Abstract: A split-frame cardiac valve (20) is configured to assume a radially compressed configuration for transcatheter delivery and a radially expanded configuration for anchoring to a native cardiac valve annulus. The split-frame cardiac valve (20) includes circumferential frame segments (22) including respective stents (24) and prosthetic leaflets (30). When the split-frame cardiac valve (20) is in the radially expanded configuration: (a) each of the stents (24) surrounds less than 360 degrees of a central longitudinal axis (26) of the split-frame cardiac valve (20), (b) the circumferential frame segments (22) are slidingly coupled to one another so as to be axially slidable with respect to one another in and out of axial alignment with one another, and (c) when the circumferential frame segments (22) are axially aligned with one another, the stents (24) collectively define a tubular stent (32) that entirely surrounds the central longitudinal axis (26).

Abstract: Auxiliary components for medical devices, and more specifically, sensing constructs that may be added to a medical device such as an implantable medical device to provide the medical device with sensing functionality. The auxiliary component is not a part of the medical device, but rather is associated with an existing medical device in a secure manner, and provides information about the medical device and/or the environment around the medical device when the device is implanted in a patient, and then transmits that information to a location outside of the patient for evaluation. Delivery systems for delivering the auxiliary components.

Abstract: A valve-delivery-assist tool (20, 120, 220, 320) is provided for use during a transcatheter aortic valve implantation (TAVI) procedure on a native aortic valve. The valve-delivery-assist tool (20, 120, 220, 320) includes a delivery catheter (22); an aortic-valve cusp guide (24), which deflects laterally upon being released from the delivery catheter (22); and a conduction-tissue protector (26, 126), which includes a sheet (28, 128) and expands upon being released from a distal end (29) of the delivery catheter (22).

Abstract: The present invention describes systems and methods for treating tricuspid valve regurgitation and mitral valve regurgitation. The treatment includes a systems and method of modifying the tricuspid or mitral valve by attaching a device in two locations in the valve annulus and pulling them toward each other to stop valve regurgitation by modifying the leaflets of the valve.

Abstract: Atrial appendage occlusion devices and cardiac monitoring positioned within the left atrial appendage and/or left atrium. In some embodiments the devices include an anchoring portion adapted to anchor the device in place adjacent the left atrial appendage, the anchoring portion comprising distal deformable anchoring portion adapted to be deployed in the left atrial appendage and a proximal deformable anchoring portion being adapted to be deployed in the left atrium, a barrier element secured to the anchoring portion and adapted to cover the left atrial appendage when implanted, and adapted to prevent blood clots from passing through the barrier element, and a cardiac monitoring element secured to at least one of the anchoring portions, the monitoring element including one or more sensors within in the left atrial appendage and/or left atrium and adapted to monitor left atrial cardiac data.

Abstract: The present invention describes systems and methods for treating mitral valve regurgitation. The treatment includes a systems and method of modifying the mitral valve by attaching a device to each leaflet and pulling them toward each other to stop mitral valve regurgitation.

Abstract: The present invention relates to an ablation equipment (100) to treat target regions of tissue (41) in organs (44), comprising an ablation catheter (1) and a single power source (4); said ablation catheter (1) comprising: a catheter elongated shaft (13) comprising at least an elongated shaft distal portion (17); said catheter elongated shaft (13) comprising a flexible body (207) to navigate through body vessels (208); said ablation catheter (1) further comprising a shaft ablation assembly (20) disposed at said elongated shaft distal portion (17); said shaft ablation assembly (2) comprising at least a plurality of electrodes (127, 113 or 114) fixedly disposed at said elongated shaft distal portion (17); all electrodes of said at least a plurality (127, 113 or 114) being electrically powered by said single power source (4) through an electric signal (S) to deliver both non-thermal energy for treating the tissue (41) and thermal energy for ablating the tissue (41); wherein said electric signal (S) comprises a si

Abstract: The present invention describes systems and methods for treating mitral valve regurgitation. The treatment includes a systems and method of modifying the mitral valve by attaching a device to each leaflet and pulling them toward each other to stop mitral valve regurgitation.

Abstract: The present invention describes systems and methods for treating mitral valve regurgitation. The treatment includes a systems and method of modifying the mitral valve by attaching a device to each leaflet and pulling them toward each other to stop mitral valve regurgitation.

Abstract: The present invention describes systems and methods for treating the left atrial appendage with an implant to fluidly seal the left atrial appendage and prevent blood from flowing from the left atrial appendage to the left atrium. The closure implant includes a braided disk, a proximal petal anchor and a distal petal anchor positioned on an implant shaft. The braided disk includes two diameters: a proximal diameter sized to engage a wall area in the left atrium around the LAA ostium; and a distal diameter sized to fit within the LAA ostium. The proximal and distal petal anchors include asymmetrical petals arranged like the petals of a flower configured to engage the wall of the LAA to anchor the implant. The implant is designed to be delivered to the heart using a catheter-based delivery system.

Abstract: The present invention describes systems and methods for treating a hole in the septum, such as a patent foramen ovale or an atrial septal defect, with a closure implant designed to fluidly seal the hole to prevent blood from flowing between the right atrium to the left atrium. The closure implant includes two structures positioned on opposite sides of the hole in septum configured to close and seal the hole. The first structure is an expandable petal anchor having multiple petal groups with multiple petals of different sizes and/or shapes made of shape memory wire configured to be positioned on a distal side of the hole in the septum wall, and the second structure is a braided disk made of shape memory mesh positioned the proximal side of the hole in the septum wall, opposite the petal anchor. The braided disk is sized to cover the hole once it is expanded. The petal anchor is designed to pull and compress the braided disk against the septum wall to cover and fluidly seal the hole.

Abstract: An occluder device is provided for occluding a cardiovascular defect or a gap between a medical device and adjacent body tissue, the device including a compliant balloon defining a fluid-tight balloon chamber and a balloon channel forming a longitudinal passage from a proximal to a distal side of the balloon, the balloon including a fluid port for filling a fluid into the balloon chamber. A tip and a base are coupled to the distal and the proximal sides of the balloon, respectively. At least one connecting strut is attached to the tip and to the base. An elongate actuator is disposed longitudinally slidable in the balloon channel and connected to the tip, and longitudinally slidable with respect to the base so as to set a distance between the tip and the base. A lock is configured to maintain the distance between the tip and the base. Other embodiments are also described.

Abstract: An occluder device is provided for occluding a cardiovascular defect or a gap between a medical device and adjacent body tissue, the device including a compliant balloon defining a fluid-tight balloon chamber and a balloon channel forming a longitudinal passage from a proximal to a distal side of the balloon, the balloon including a fluid port for filling a fluid into the balloon chamber. A tip and a base are coupled to the distal and the proximal sides of the balloon, respectively. At least one connecting strut is attached to the tip and to the base. An elongate actuator is disposed longitudinally slidable in the balloon channel and connected to the tip, and longitudinally slidable with respect to the base so as to set a distance between the tip and the base. A lock is configured to maintain the distance between the tip and the base. Other embodiments are also described.

Abstract: Provided herein are systems for stimulating cardiac tissue of a patient. The systems include: a pulse generator having a first transmission element for delivering wireless power; a stimulation assembly having a flexible substrate, a second transmission element for receiving the wireless power from the first transmission element of the pulse generator, one or more electrodes attached to the substrate for delivering electrical energy to cardiac tissue, and one or more microcircuits attached to the substrate for delivering electrical energy to the one or more electrodes; and an algorithm having a fibrillation detection algorithm for determining when the one or more electrodes deliver the energy to the cardiac tissue.

Abstract: Atrial appendage occlusion devices and cardiac monitoring positioned within the left atrial appendage and/or left atrium. In some embodiments the devices include an anchoring portion adapted to anchor the device in place adjacent the left atrial appendage, the anchoring portion comprising distal deformable anchoring portion adapted to be deployed in the left atrial appendage and a proximal deformable anchoring portion being adapted to be deployed in the left atrium, a barrier element secured to the anchoring portion and adapted to cover the left atrial appendage when implanted, and adapted to prevent blood clots from passing through the barrier element, and a cardiac monitoring element secured to at least one of the anchoring portions, the monitoring element including one or more sensors within in the left atrial appendage and/or left atrium and adapted to monitor left atrial cardiac data.

Abstract: The present invention relates to an ablation equipment (100) to treat target regions of tissue (41) in organs (44), comprising an ablation catheter (1) and a single power source (4); said ablation catheter (1) comprising: a catheter elongated shaft (13) comprising at least an elongated shaft distal portion (17); said catheter elongated shaft (13) comprising a flexible body (207) to navigate through body vessels (208); said ablation catheter (1) further comprising a shaft ablation assembly (20) disposed at said elongated shaft distal portion (17); said shaft ablation assembly (2) comprising at least a plurality of electrodes (127, 113 or 114) fixedly disposed at said elongated shaft distal portion (17); all electrodes of said at least a plurality (127, 113 or 114) being electrically powered by said single power source (4) through an electric signal (S) to deliver both non-thermal energy for treating the tissue (41) and thermal energy for ablating the tissue (41); wherein said single power source (4), w

Abstract: The present invention relates to an ablation assembly (100) to treat target regions of a tissue (41) in organs (44) comprising: an ablation catheter (1) comprising an elongate shaft (13) having a longitudinal main direction (X-X), said elongate shaft (13) comprising at least a shaft distal portion (17), said shaft distal portion (17) comprising a shaft distal portion distal end (19); said ablation catheter (1) comprising an inner lumen (118) arranged within the elongate shaft (13); said ablation catheter (1) comprising a shaft ablation assembly (20) fixedly disposed at said shaft distal portion (17), the shaft ablation assembly (20) being configured to deliver both thermal energy for ablating said tissue (41) and non-thermal energy for treating said tissue (41); at least a shape setting mandrel (26) disposed within the ablation catheter (1), the shape setting mandrel (26) being insertable within the inner lumen (118) and removable from the inner lumen (118), wherein the shape setting mandrel (26) is fr

Abstract: An instrument for repairing an atrioventricular heart valve, mitral heart valve or tricuspid heart valve includes a first tube having a tube axis defining an axial direction. A leaflet grabbing structure is arranged at a distal part of the first tube and contiguous to the first tube. The leaflet grabbing structure has a main body and a jaw, the jaw being movable relative to the main body. The jaw has a first proximally facing abutment surface and the main body has a second, distally facing abutment surface. The instrument has a needle that is cannulated and forms an inner tube. The needle is releasable from the first tube and movable relative to the main body in axial directions. The leaflet grabbing structure clamps a leaflet of the heart valve between the first and second abutment surfaces, while the jaw allows the needle to extend therethrough.

Abstract: A system for treating and/or monitoring a medical condition of a patient comprises: an implant configured to be inserted into a body space of the patient, such as the left atrial appendage. The implant comprises a frame or ring configured to engage tissue of the patient proximate the body space. Methods of treating and/or monitoring a medical condition of a patient are also provided.