Abstract: Described herein are methods and techniques for the determination of reactive oxygen species in resected animal and human tissues. Also described herein are methods for determining the efficacy of anti-oxidant, oxidative stress modulatory, or anti-inflammatory drug chemoprevention or chemotherapy for the prevention and/or therapy of chronically inflamed and/or progressive cancers and pathophysiologies.

Abstract: The invention relates to compositions and methods for targeting sequence modifications in one or more genes of a related family of genes using enhanced homologous recombination techniques. These techniques may be used to create animal or plant models of disease as well as to identify new targets for drug or pathogen screening.

Abstract: The invention relates to methods for targeting an exogenous polynucleotide or exogenous complementary polynucleotide pair to a predetermined endogenous DNA target sequence in a target cell by homologous pairing, particularly for altering an endogenous DNA sequence, such as a chromosomal DNA sequence, typically by targeted homologous recombination. In certain embodiments, the invention relates to methods for targeting an exogenous polynucleotide having a linked chemical substituent to a predetermined endogenous DNA sequence in a metabolically active target cell, generating a DNA sequence-specific targeting of one or more chemical substituents in an intact nucleus of a metabolically active target cell, generally for purposes of altering a predetermined endogenous DNA sequence in the cell.

Abstract: Compositions and methods are provided for rapidly evolving specific protein domains employing a recombinase and recombination intermediates.

Abstract: The invention relates to methods and compositions for producing transgenic animals by targeted homologous recombination comprising targeting an exogenous polynucleotide or exogenous complementary polynucleotide pair to a predetermined endogenous DNA target sequence in a target cell by homologous pairing, particularly for altering an endogenous DNA sequence, such as a chromosomal DNA sequence. In certain embodiments, the invention relates to compositions that contain exogenous targeting polynucleotides, complementary pairs of exogenous targeting polynucleotides, chemical substituents of such polynucleotides, and recombinase proteins used in the methods of the invention.

Abstract: The present invention is directed to methods and systems for integrating the provision of genomics services and the production of genomics products. In one aspect of the invention, a method is provided for integrated genomic services comprising (a) receiving a first request from a customer, wherein said request comprises a first nucleic acid sequence, and an order for at least two genomics products or services; and (b) utilizing said nucleic acid sequence to provide said at least two genomics services or products.