Patents by Inventor David ZHITOMIRSKY
David ZHITOMIRSKY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11946901Abstract: A method for degassing a microfluidic droplet by combining electrowetting and heating to induce formation of gaseous bubbles in the droplet. In an embodiment the methods are carried out on an active matrix of electrowetting electrodes including a hydrophobic coating. A carrier fluid is flowed against the droplet motion propelled by electrowetting to facilitate rapid removal of the gasses departing the droplet.Type: GrantFiled: January 25, 2021Date of Patent: April 2, 2024Assignee: Nuclera LTDInventors: Tanya Gupta, Luke M. Slominski, David Zhitomirsky, Richard J. Paolini, Jr.
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Patent number: 11927740Abstract: An active matrix electrowetting on dielectric (AM-EWoD) device including a substrate with thin-film transistors (TFT), a dielectric layer, and a spatially variable wettability layer covering the dielectric layer. As depicted herein, the spatially variable wettability layer may include a plurality of portions having different contact angles, one or more contact angle gradients, or both.Type: GrantFiled: November 19, 2020Date of Patent: March 12, 2024Assignee: Nuclera LTDInventor: David Zhitomirsky
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Publication number: 20230372939Abstract: A method for moving an aqueous droplet comprising providing an electrokinetic device including a first substrate having a matrix of electrodes, wherein each of the matrix electrodes is coupled to a thin film transistor, and wherein the matrix electrodes are overcoated with a functional coating comprising: a dielectric layer in contact with the matrix electrodes, a conformal layer in contact with the dielectric layer, and a hydrophobic layer in contact with the conformal layer; a second substrate comprising a top electrode; a spacer disposed between the first substrate and the second substrate and defining an electrokinetic workspace; and a voltage source operatively coupled to the matrix electrodes. The method further comprises disposing an aqueous droplet on a first matrix electrode; and providing a differential electrical potential between the first matrix electrode and a second matrix electrode with the voltage source, thereby moving the aqueous droplet.Type: ApplicationFiled: April 14, 2021Publication date: November 23, 2023Inventors: Michael Chun Hao Chen, Sumit Kalsi, Laurence Livingstone Bell, Gordon Ross McInroy, David Zhitomirsky, Luke M Slominski, RicK J Paolini, JR., Cristina Visani
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Patent number: 11806715Abstract: A method for moving an aqueous droplet comprising providing an electrokinetic device including a first substrate having a matrix of electrodes, wherein each of the matrix electrodes is coupled to a thin film transistor, and wherein the matrix electrodes are overcoated with a functional coating comprising: a dielectric layer in contact with the matrix electrodes, a conformal layer in contact with the dielectric layer, and a hydrophobic layer in contact with the confornial layer; a second substrate comprising a top electrode; a spacer disposed between the first substrate and the second substrate and defining an electrokinetic workspace; and a voltage source operatively coupled to the niatrix electrodes. The method further comprises disposing an aqueous droplet on a first matrix electrode; and providing a differential electrical potential between the first matrix electrode and a second matrix electrode with the voltage source, thereby moving the aqueous droplet.Type: GrantFiled: October 13, 2022Date of Patent: November 7, 2023Assignee: Nuclera LtdInventors: Michael Chun Hao Chen, Sumit Kalsi, Laurence Livingstone Bell, Gordon Ross McInroy, David Zhitomirsky, Luke M. Slominski, Richard J. Paolini, Jr., Cristina Visani
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Publication number: 20230241606Abstract: A digital microfluidic device including a top plate and a bottom plate. The top plate includes a top plate substrate, a top plate common electrode, and a first hydrophobic layer covering the top plate common electrode. A plurality of wells are present in the top plate, and the surface of at least one of the wells is more hydrophilic than the surface of the first hydrophobic layer. The bottom plate includes a bottom electrode array comprising a plurality of digital microfluidic propulsion electrodes, and a second hydrophobic layer covering the bottom electrode array. The top plate and the bottom plate are provided in a spaced relationship defining a microfluidic region therebetween to permit droplet motion within the microfluidic region under application of propulsion voltages between the bottom electrode array and the common top electrode.Type: ApplicationFiled: June 15, 2021Publication date: August 3, 2023Inventors: David Zhitomirsky, Richard J. Paolini, JR., Luke Slominski
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Patent number: 11596946Abstract: A digital microfluidic device, comprising a bottom plate and a top plate. The bottom plate comprises a bottom electrode array comprising a plurality of digital microfluidic propulsion electrodes. The top plate comprises a segmented top electrode array comprising a plurality of separately voltage addressable top electrode segments. Each top electrode segment and at least two of the propulsion electrodes of the bottom electrode array form a zone within the device. A controller is operatively coupled to the top electrode array and to the bottom electrode array and is configured to provide propulsion voltages between the top plate segment and the bottom plate propulsion electrodes of at least one of the zones. The top plate and the bottom plate are provided in a spaced relationship defining a microfluidic region therebetween.Type: GrantFiled: April 26, 2021Date of Patent: March 7, 2023Assignee: Nuclera Nucleics Ltd.Inventors: David Zhitomirsky, Richard J. Paolini, Jr.
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Publication number: 20230057330Abstract: A method for moving an aqueous droplet comprising providing an electrokinetic device including a first substrate having a matrix of electrodes, wherein each of the matrix electrodes is coupled to a thin film transistor, and wherein the matrix electrodes are overcoated with a functional coating comprising: a dielectric layer in contact with the matrix electrodes, a conformal layer in contact with the dielectric layer, and a hydrophobic layer in contact with the confornial layer; a second substrate comprising a top electrode; a spacer disposed between the first substrate and the second substrate and defining an electrokinetic workspace; and a voltage source operatively coupled to the niatrix electrodes. The method further comprises disposing an aqueous droplet on a first matrix electrode; and providing a differential electrical potential between the first matrix electrode and a second matrix electrode with the voltage source, thereby moving the aqueous droplet.Type: ApplicationFiled: October 13, 2022Publication date: February 23, 2023Inventors: Michael Chun Hao Chen, Sumit Kalsi, Laurence Livingstone Bell, Gordon Ross McInroy, David Zhitomirsky, Luke Slominski, Rick Paolini, JR., Cristina Visani
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Patent number: 11554374Abstract: A digital microfluidic device including an active matrix of propulsion electrodes controlled by thin-film-transistors. The device includes at least two areas of different propulsion electrode densities. One area may be driven by directly-driving the propulsion electrodes from a power supply or function generator. In the first, higher density region; a first dielectric layer covers the propulsion electrodes. The first dielectric layer has a first dielectric constant and a first thickness. In the second, lower density region, a second dielectric layer has a second dielectric constant and a second thickness covering the propulsion electrodes.Type: GrantFiled: January 15, 2021Date of Patent: January 17, 2023Assignee: Nuclera Nucleics Ltd.Inventors: David Zhitomirsky, Cristina Visani
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Patent number: 11353759Abstract: Active matrix backplanes including an array of hexagonal electrodes or an array of triangular electrodes. Because the backplane designs route the gate lines along the periphery of the electrodes there is less cross talk with the surface of the electrode. The disclosed designs simplify construction and control of the electrodes and improve the regularity of the electric field above the electrode. Such backplane electrode designs may be particularly useful in electrowetting on dielectric (EWoD) devices and electrophoretic displays (EPD).Type: GrantFiled: September 16, 2019Date of Patent: June 7, 2022Assignee: Nuclera Nucleics Ltd.Inventors: Annie Tsai, Ian French, Cristina Visani, David Zhitomirsky, Richard J. Paolini, Jr.
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Publication number: 20220111387Abstract: An electrowetting system for actuating droplets of a first composition and of a second composition. The system includes: a plurality of electrodes configured to manipulate droplets of fluid in a microfluidic space, each electrode being coupled to circuitry which applies driving voltages to the electrode; and a processing unit operably connected to a look up table correlating drive sequences to chemical species and at least one composition parameter. The processing unit is configured to: receive data of a first chemical species and a first composition parameter of the first composition; receive data of a second chemical species and a second composition parameter of the second composition; correlate a first drive sequence with the first chemical species and the first composition parameter; correlate a second drive sequence with the second chemical species and the second composition parameter; and output the first drive sequence and the second drive sequence to the electrodes.Type: ApplicationFiled: October 8, 2021Publication date: April 14, 2022Inventors: Richard J. Paolini, JR., Luke M. Slominski, Timothy J. O'Malley, David Zhitomirsky
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Publication number: 20220008921Abstract: A digital microfluidic system, comprising: (a) a bottom plate comprising an electrode array comprising a plurality of digital microfluidic propulsion electrodes; (b) a top plate comprising a common top electrode; (c) a controller coupled to the processing unit, common top electrode, and bottom electrode array; and (d) a processing unit operably programmed to: receiving input instructions relating to a droplet diameter and aspect ratio; calculating actuation parameters comprising: a length of an actuated hold, a length of an actuated neck, and a height of an actuated head, for dispensing a droplet having the diameter and aspect ratio of the input instructions; outputting electrode actuation to the controller, the electrode actuation instructions relating to a dispense driving sequence for implementing the calculated actuation parameters, to dispense having the input diameter and aspect ratio; wherein the electrodes have a dimension less than the diameter of the droplet.Type: ApplicationFiled: May 28, 2021Publication date: January 13, 2022Inventor: DAVID ZHITOMIRSKY
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Publication number: 20210331176Abstract: A digital microfluidic device, comprising a bottom plate and a top plate. The bottom plate comprises a bottom electrode array comprising a plurality of digital microfluidic propulsion electrodes. The top plate comprises a segmented top electrode array comprising a plurality of separately voltage addressable top electrode segments. Each top electrode segment and at least two of the propulsion electrodes of the bottom electrode array form a zone within the device. A controller is operatively coupled to the top electrode array and to the bottom electrode array and is configured to provide propulsion voltages between the top plate segment and the bottom plate propulsion electrodes of at least one of the zones. The top plate and the bottom plate are provided in a spaced relationship defining a microfluidic region therebetween.Type: ApplicationFiled: April 26, 2021Publication date: October 28, 2021Inventors: David ZHITOMIRSKY, Richard J. PAOLINI, JR.
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Publication number: 20210231606Abstract: A method for degassing a microfluidic droplet by combining electrowetting and heating to induce formation of gaseous bubbles in the droplet. In an embodiment the methods are carried out on an active matrix of electrowetting electrodes including a hydrophobic coating. A carrier fluid is flowed against the droplet motion propelled by electrowetting to facilitate rapid removal of the gasses departing the droplet.Type: ApplicationFiled: January 25, 2021Publication date: July 29, 2021Inventors: Tanya GUPTA, Luke M. SLOMINSKI, David ZHITOMIRSKY, Richard J. PAOLINI, JR.
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Publication number: 20210220830Abstract: A digital microfluidic device including an active matrix of propulsion electrodes controlled by thin-film-transistors. The device includes at least two areas of different propulsion electrode densities. One area may be driven by directly-driving the propulsion electrodes from a power supply or function generator. In the first, higher density region; a first dielectric layer covers the propulsion electrodes. The first dielectric layer has a first dielectric constant and a first thickness. In the second, lower density region, a second dielectric layer has a second dielectric constant and a second thickness covering the propulsion electrodes.Type: ApplicationFiled: January 15, 2021Publication date: July 22, 2021Inventors: David ZHITOMIRSKY, Cristina VISANI
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Publication number: 20210170413Abstract: A digital microfluidic device including a substrate and a controller. The substrate includes: a first high-resolution area and a second low-resolution area, and a hydrophobic layer. The first area includes a first plurality of electrodes having a first density D1, and a first set of thin-film-transistors coupled to the first plurality of electrodes. The second area includes a second plurality of electrodes having a second density D2, where D2<D1, and a second set of thin-film-transistors coupled to the second plurality of electrodes. The hydrophobic layer covers both the first and second pluralities of electrodes and the first and second sets of thin-film-transistors. The controller is operatively coupled to the first set and second set of thin-film-transistors and configured to provide a propulsion voltage to at least a portion of the first plurality of electrodes and at least a portion of the second plurality of electrodes.Type: ApplicationFiled: December 3, 2020Publication date: June 10, 2021Inventors: David ZHITOMIRSKY, Richard J. PAOLINI, Jr., Ian FRENCH, Timothy J. O'MALLEY
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Publication number: 20210149184Abstract: An active matrix electrowetting on dielectric (AM-EWoD) device including a substrate with thin-film transistors (TFT), a dielectric layer, and a spatially variable wettability layer covering the dielectric layer. As depicted herein, the spatially variable wettability layer may include a plurality of portions having different contact angles, one or more contact angle gradients, or both.Type: ApplicationFiled: November 19, 2020Publication date: May 20, 2021Inventor: David ZHITOMIRSKY
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Patent number: 10865336Abstract: A polymer consisting of small functional molecules can be integrated into solar thermal fuels in the solid-state for solar energy harvesting and storage. In certain embodiments, a solar energy storage device can include one or more layers of photoswitchable moieties associated with a polymer. Such solar thermal fuel polymers can be used to enable deposition from low concentration solutions, resulting in uniform and large-area thin-films. This approach enables conformal deposition on a variety of conducting substrates that can be either flat or structured and control over film growth via electrodeposition conditions and results in highly uniform and large-area thin films.Type: GrantFiled: December 11, 2016Date of Patent: December 15, 2020Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Jeffrey C. Grossman, David Zhitomirsky
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Publication number: 20200347840Abstract: A microfluidic device including: (a) top plate, including: a top substrate; a first layer of hydrophobic material coupled to a surface of the top substrate; a continuous electrode between the first layer of hydrophobic material and the top substrate; (b) a bottom plate, comprising: a bottom substrate; a plurality of electrodes coupled to the bottom substrate; a second layer of hydrophobic material coupled to the second substrate and atop the plurality of electrodes. The top plate and the bottom plate are placed in a spaced relationship, thereby defining a gap between the first and second layers of hydrophobic material to permit droplet motion within the gap under application of propulsion voltages. At least one of the top substrate, the first layer of hydrophobic material, the second layer of hydrophobic material, the bottom substrate, and the plurality of electrodes have a non-uniform thickness, and the gap has a plurality of heights.Type: ApplicationFiled: April 22, 2020Publication date: November 5, 2020Inventors: Richard J. PAOLINI, JR., David ZHITOMIRSKY, Timothy J. O'MALLEY
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Publication number: 20200089035Abstract: Active matrix backplanes including an array of hexagonal electrodes or an array of triangular electrodes. Because the backplane designs route the gate lines along the periphery of the electrodes there is less cross talk with the surface of the electrode. The disclosed designs simplify construction and control of the electrodes and improve the regularity of the electric field above the electrode. Such backplane electrode designs may be particularly useful in electrowetting on dielectric (EWoD) devices and electrophoretic displays (EPD).Type: ApplicationFiled: September 16, 2019Publication date: March 19, 2020Inventors: Annie Tsai, Ian French, Cristina Visani, David Zhitomirsky, Richard J. Paolini, JR.
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Publication number: 20180355234Abstract: A polymer consisting of small functional molecules can be integrated into solar thermal fuels in the solid-state for solar energy harvesting and storage. In certain embodiments, a solar energy storage device can include one or more layers of photoswitchable moieties associated with a polymer. Such solar thermal fuel polymers can be used to enable deposition from low concentration solutions, resulting in uniform and large-area thin-films. This approach enables conformal deposition on a variety of conducting substrates that can be either flat or structured and control over film growth via electrodeposition conditions and results in highly uniform and large-area thin films.Type: ApplicationFiled: December 11, 2016Publication date: December 13, 2018Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Jeffrey C. GROSSMAN, David ZHITOMIRSKY