Patents by Inventor David ZILIAN

David ZILIAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENERATION OF ANTIBODY-DERIVED POLYPEPTIDES BY POLYPEPTIDE CHAIN EXCHANGE
    Publication number: 20220033525
    Abstract: The present invention relates to a set of heterodimeric polypeptides and its uses, e.g. for generating multispecific antigen binders by polypeptide chain exchange.
    Type: Application
    Filed: October 21, 2021
    Publication date: February 3, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Ulrich Brinkmann, Can Martin Buldun, Stefan Dengle, Steffen Dickopf, Guy Georges, Eike Hoffmann, Sabine Imhof-Jung, David Zilian
  • Tetrahydroisoquinolinone derivatives and their use in the inhibition of the HSP70 protein
    Patent number: 9975853
    Abstract: The present invention relates to tetrahydroisoquinolinone derivatives, a pharmaceutical composition comprising the same and the use of these derivatives in the inhibition of the Hsp70 protein. The compounds are useful in the treatment or inhibition of cancer, autoimmune disease, rheumatoid arthritis, inflammatory bowel disease and psoriasis.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: May 22, 2018
    Inventors: Manik Chatterjee, Andreas Hartung, Ulrike Holzgrabe, Elisabeth Mueller, Ulrich Peinz, Christoph Sotriffer, David Zilian
  • TETRAHYDROISOQUINOLINONE DERIVATIVES AND THEIR USE IN THE INHIBITION OF THE HSP70 PROTEIN
    Publication number: 20170152229
    Abstract: The present invention relates to tetrahydroisoquinolinone derivatives, a pharmaceutical composition comprising the same and the use of these derivatives in the inhibition of the Hsp70 protein. The compounds are useful in the treatment or inhibition of cancer, autoimmune disease, rheumatoid arthritis, inflammatory bowel disease and psoriasis.
    Type: Application
    Filed: June 3, 2014
    Publication date: June 1, 2017
    Applicant: Julius-Maximilians-Universitaet Wuerzburg
    Inventors: Manik CHATTERJEE, Andreas HARTUNG, Ulrike HOLZGRABE, Elisabeth MUELLER, Ulrich PEINZ, Christoph SOTRIFFER, David ZILIAN