Patents by Inventor David Zopf
David Zopf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230267854Abstract: An anatomical movement simulation assembly and a method of simulating anatomical movements. One or more additive-manufactured body part models anatomically approximates a corresponding physical body part(s), or exhibits anatomical accuracy relative to the corresponding physical body part(s). The physical body part(s) modeled include a rib cage, lungs, diaphragm, tongue, jaw and teeth, vocal folds, and larynx, among other possibilities. Movement is imparted to the additive-manufactured body part model(s), for instance via pump, motor, or manual actuation, in order to replicate the physiologically normal movement of the corresponding physical body part(s). Educators, musicians, singers, actors, students, doctors, and patients, as well as others, may find productive use observing such anatomical movement simulations.Type: ApplicationFiled: February 21, 2023Publication date: August 24, 2023Inventors: David A. ZOPF, Amy K. PORTER
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Publication number: 20230172706Abstract: Ear implants for auricular tissue reconstruction in a patient are provided. The ear implant may be a tissue scaffold multicomponent assembly for reconstruction of auricular tissue. Thus, the assembly may include both a first and a second tissue scaffold component. Each comprises a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The first tissue scaffold component defines a central void region and at least a portion of an outer ear framework of the patient after implantation. The second tissue scaffold component defines a base portion. After implantation into the patient, the second tissue scaffold component seats within the central void region of the first tissue scaffold component, so that the second tissue scaffold component is secured to the first tissue scaffold component. Methods for reconstructing auricular tissue in a patient using such ear implant tissue scaffolds are also provided.Type: ApplicationFiled: January 30, 2023Publication date: June 8, 2023Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: David A. ZOPF, Scott J. HOLLISTER
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Patent number: 11564792Abstract: Ear implants for auricular tissue reconstruction in a patient are provided. The ear implant may be a tissue scaffold multicomponent assembly for reconstruction of auricular tissue. Thus, the assembly may include both a first and a second tissue scaffold component. Each comprises a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The first tissue scaffold component defines a central void region and at least a portion of an outer ear framework of the patient after implantation. The second tissue scaffold component defines a base portion. After implantation into the patient, the second tissue scaffold component seats within the central void region of the first tissue scaffold component, so that the second tissue scaffold component is secured to the first tissue scaffold component. Methods for reconstructing auricular tissue in a patient using such ear implant tissue scaffolds are also provided.Type: GrantFiled: April 26, 2018Date of Patent: January 31, 2023Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: David A. Zopf, Scott J. Hollister
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Publication number: 20230010971Abstract: A nasal tissue implant for reconstruction and tissue engineering of nasal tissue in a subject includes a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The tissue scaffold component conforms to a portion of the subject's nasal region and defines at least a portion of the subject's nasal anatomy. A method of making an implantable nasal tissue implant for reconstructing a portion of a nasal anatomy of a human or other animal subject is also provided that includes laser sintering or three-dimensional (3D) printing a biocompatible polymeric material to form a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. Again, the tissue scaffold component substantially conforms to a nasal region specific to the human or other animal subject.Type: ApplicationFiled: August 31, 2022Publication date: January 12, 2023Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, GEORGIA TECH RESEARCH CORPORATIONInventors: David ZOPF, Scott J. HOLLISTER
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Patent number: 11458012Abstract: A nasal tissue implant for reconstruction and tissue engineering of nasal tissue in a subject includes a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The tissue scaffold component conforms to a portion of the subject's nasal region and defines at least a portion of the subject's nasal anatomy. A method of making an implantable nasal tissue implant for reconstructing a portion of a nasal anatomy of a human or other animal subject is also provided that includes laser sintering or three-dimensional (3D) printing a biocompatible polymeric material to form a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. Again, the tissue scaffold component substantially conforms to a nasal region specific to the human or other animal subject.Type: GrantFiled: June 7, 2019Date of Patent: October 4, 2022Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Georgia Tech Research CorporationInventors: David Zopf, Scott J. Hollister
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Patent number: 11337862Abstract: An ear splint for an ear is provided having a central portion having an exterior surface defining a first topology that is configured to dwell within an anterior scaphoid section of an ear, and a wing portion extending from the central portion and integrally formed therewith and at least partially surrounding an outer periphery of the central portion. The wing portion includes an exterior surface defining a second topology and is configured to be positioned along a postauricular area of the ear. The first magnetic device is disposed in the central portion and the second magnetic device is disposed in the wing portion. The magnetic retention feature exert a magnetic attractive force between the central portion and the wing portion such that at least a portion of the exterior surface of the central portion and at least a portion of the exterior surface of the wing portion contact the ear.Type: GrantFiled: September 15, 2017Date of Patent: May 24, 2022Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: David Zopf, Kevin Green, Kyle Vankoevering
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Publication number: 20210299388Abstract: A system for providing mechanical ventilation to a plurality of patients using a single ventilator is provided. The system includes a first branched adapter may be coupled to a ventilator, the first branched adapter having a plurality of branches and configured to divide a ventilator gas stream into a plurality of gas streams for delivery to a respective plurality of patients. The system includes a pressure regulator in fluid communication with one branch of the first branched adapter and with one patient, the pressure regulator being configured to reduce the pressure of the gas stream reaching the patient such that it is less pressurized than the ventilator gas stream. The system includes a second branched adapter may be coupled to a ventilator, the second branched adapter having a plurality of branches and configured to unite expired gas streams from the plurality of patients into a single expiratory gas stream.Type: ApplicationFiled: March 31, 2021Publication date: September 30, 2021Inventors: Kyle VANKOEVERING, Owen TIEN, Glenn E GREEN, David A. ZOPF
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Publication number: 20210282974Abstract: An ear splint for an ear is provided having a central portion having an exterior surface defining a first topology that is configured to dwell within an anterior scaphoid section of an ear, and a wing portion extending from the central portion and integrally formed therewith and at least partially surrounding an outer periphery of the central portion. The wing portion includes an exterior surface defining a second topology and is configured to be positioned along a postauricular area of the ear. The first magnetic device is disposed in the central portion and the second magnetic device is disposed in the wing portion. The magnetic retention feature exert a magnetic attractive force between the central portion and the wing portion such that at least a portion of the exterior surface of the central portion and at least a portion of the exterior surface of the wing portion contact the ear.Type: ApplicationFiled: September 15, 2017Publication date: September 16, 2021Inventors: David ZOPF, Kevin GREEN, Kyle VANKOEVERING
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Publication number: 20200188090Abstract: Ear implants for auricular tissue reconstruction in a patient are provided. The ear implant may be a tissue scaffold multicomponent assembly for reconstruction of auricular tissue. Thus, the assembly may include both a first and a second tissue scaffold component. Each comprises a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The first tissue scaffold component defines a central void region and at least a portion of an outer ear framework of the patient after implantation. The second tissue scaffold component defines a base portion. After implantation into the patient, the second tissue scaffold component seats within the central void region of the first tissue scaffold component, so that the second tissue scaffold component is secured to the first tissue scaffold component. Methods for reconstructing auricular tissue in a patient using such ear implant tissue scaffolds are also provided.Type: ApplicationFiled: April 26, 2018Publication date: June 18, 2020Applicant: The Regents of the University of MichiganInventors: David A. ZOPF, Scott J. HOLLISTER
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Publication number: 20190374336Abstract: A nasal tissue implant for reconstruction and tissue engineering of nasal tissue in a subject includes a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The tissue scaffold component conforms to a portion of the subject's nasal region and defines at least a portion of the subject's nasal anatomy. A method of making an implantable nasal tissue implant for reconstructing a portion of a nasal anatomy of a human or other animal subject is also provided that includes laser sintering or three-dimensional (3D) printing a biocompatible polymeric material to form a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. Again, the tissue scaffold component substantially conforms to a nasal region specific to the human or other animal subject.Type: ApplicationFiled: June 7, 2019Publication date: December 12, 2019Inventors: David ZOPF, Scott J. HOLLISTER
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Publication number: 20170007712Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.Type: ApplicationFiled: August 1, 2016Publication date: January 12, 2017Applicant: Novo Nordisk A/SInventors: Shawn DeFrees, David A. Zopf, Robert J. Bayer, David Hakes, Caryn L. Bowe, Xi Chen
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Publication number: 20160200795Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.Type: ApplicationFiled: December 18, 2015Publication date: July 14, 2016Applicant: Novo Nordisk A/SInventors: Shawn DeFrees, David A. Zopf, Robert J. Bayer, Caryn Bowe, David James Hakes, Xi Chen
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Publication number: 20160193353Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.Type: ApplicationFiled: March 16, 2016Publication date: July 7, 2016Applicant: Novo Nordisk A/SInventors: Shawn DeFrees, David A. Zopf, Robert J. Bayer, Caryn Bowe, David James Hakes, Xi Chen
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Publication number: 20150343080Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.Type: ApplicationFiled: May 26, 2015Publication date: December 3, 2015Inventors: Shawn DeFrees, David A. Zopf, Robert J. Bayer, David James Hakes, Caryn L. Bowe, Xi Chen
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Patent number: 9050304Abstract: The present invention provides a glycopegylated G-CSF that is therapeutically active and which has pharmacokinetic parameters and properties that are improved relative to an identical, or closely analogous, G-CSF peptide that is not glycopegylated. Furthermore, the invention provides methods for mobilizing hematopoiesis in a subject, particularly a subject who has received or will receive radiation or chemotherapy treatment. The methods and compositions of the invention can further be used to prevent, alleviate and treat the myelosuppressive effects such therapies.Type: GrantFiled: April 1, 2008Date of Patent: June 9, 2015Assignee: ratiopharm GmbHInventors: David A. Zopf, Heinz Lubenau
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Patent number: 9029331Abstract: The invention relates to methods of preparing and purifying conjugates between Granulocyte Colony Stimulating Factor and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are purified using various chromatography methods.Type: GrantFiled: January 10, 2006Date of Patent: May 12, 2015Assignee: Novo Nordisk A/SInventors: Shawn DeFrees, Henrik Clausen, David A. Zopf, Caryn Bowe, Susann Taudte, Michael Felo, Walter S. Willett
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Patent number: 8916360Abstract: The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.Type: GrantFiled: June 10, 2011Date of Patent: December 23, 2014Assignee: Novo Nordisk A/SInventors: Shawn DeFrees, David A. Zopf, Caryn Lang Bowe
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Patent number: 8911967Abstract: The present invention provides conjugates between peptides and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from both glycosylated and unglycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto either an amino acid or glycosyl residue on the peptide. Also provided are pharmaceutical formulations including the conjugates. Methods for preparing the conjugates are also within the scope of the invention.Type: GrantFiled: May 20, 2010Date of Patent: December 16, 2014Assignee: Novo Nordisk A/SInventors: Shawn DeFrees, David A. Zopf, Susann Taudte, Walter Scott Willett, Robert J. Bayer, Matthew Kalo
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Patent number: 8853161Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.Type: GrantFiled: September 27, 2011Date of Patent: October 7, 2014Assignee: Novo Nordisk A/SInventors: Shawn DeFrees, David A. Zopf, Robert J. Bayer, David James Hakes, Caryn Bowe, Xi Chen
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Publication number: 20140294762Abstract: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.Type: ApplicationFiled: April 7, 2014Publication date: October 2, 2014Applicant: Novo Nordisk A/SInventors: Shawn DeFrees, David A. Zopf, Robert J. Bayer, David James Hakes, Caryn L. Bowe, Xi Chen