Abstract: A load controller in a load control system may communicate messages with load control devices for controlling electrical loads. The load controller may receive messages that comprise values for controlling different load control parameters over different overlapping fade times. The load controller may identify a shorter remaining fade time for controlling one of the load control parameters and may determine an updated target value for controlling another load control parameter over the shorter remaining fade time. The load controller may transmit a series of messages within a limited fade time using an updated target value for each message to control an electrical load at a fade rate that during a fade time that is longer than the limited fade time.

Abstract: A safety system for a heat pump system includes a plurality of valve units each having refrigerant pipe portions with control valves, a refrigerant leakage detector, and a casing accommodating the valves and the refrigerant leakage detector and formed with first and second openings. The safety system further includes a connection structure connecting the internal spaces of the casings via the first and second openings, and a discharge structure connected to the connection structure or one of the casings and configured to discharge air from the internal space of the casing in which a refrigerant leakage has occurred. The casing has first and second lateral faces facing different directions, and the first opening is formed in the first lateral face and the second opening is formed in the second lateral face.

Abstract: A plastic molding method comprises moving each part of a plurality of parts along a selected one of a plurality of possible paths through dispensing and molding stations of a molding system. A controller tracks an operating state of each station, selects process stations capable of receiving a part for processing; identifies parts capable of processing at the selected process stations, and assigns individual parts to individual process stations.

Abstract: A general purpose sensor architecture integrating a surface enhanced Raman spectroscopy (SERS) substrate, a diffractive laser beam delivery substrate and a diffractive infrared detection substrate is provided that can be used to implement a low-cost, compact lab-on-a-chip biosensor that can meet the needs of large-scale infectious disease testing. The sensor architecture can also be used in any other application in which molecules present in the liquid, gaseous or solid phases need to be characterized reliably, cost-effectively and with minimal intervention by highly skilled personnel.

Abstract: A diagnostic tool for use in diagnosing a vehicle comprises a data interface for accessing an electronic control unit (ECU) of a vehicle and receiving diagnostic data from the ECU, a processor for generating a barcode encoding at least a portion of the received diagnostic data, and a display for displaying the generated barcode to allow for contactless transmission of the at least a portion of the received diagnostic data to an external device independent of any need for electrical or bidirectional communication with the external device. An external device may capture an image of the barcode, decode the at least a portion of the received diagnostic data based on the captured image of the barcode, transmit the decoded diagnostic data to a server, and receive vehicle condition information from the server based on the decoded diagnostic data.

Abstract: The present disclosure relates generally to methods and systems for detecting, characterizing biomarker expression and morphological analysis in cell samples. The methods allow for the use of automated platforms to stain cells for molecular biomarkers and Romanowsky-type staining for cell morphology analysis. Cells that are prepared according to the disclosed methods can also be used in the diagnosis of certain conditions.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed for a window-metric rule for return path data (RPD). In some examples, a media monitor is to determine a first count of a number of devices in a first household that reported RPD for a first day, and compare the first count to a current window-metric, the current window-metric associated with a window of time for the first household, the window of time associated with a content provider and having N number of days. In some examples, the media monitor is also to exclude the RPD from the first household for the first day when the first count does not satisfy the current window-metric, and generate a media exposure report using the RPD from the first household for the first day when the first count satisfies the current window-metric, independent of if the first household has heartbeat data available.

Abstract: Methods of facilitating human interpretation of a plurality of time-series datasets generated from operation of hydrocarbon wells. The methods include obtaining the plurality of time-series datasets and displaying a vector map. The plurality of time-series datasets is generated from an operation of the hydrocarbon well and includes a first time-series dataset and a second time-series dataset, and optionally may include a third time-series dataset. The vector map includes a time axis and a plurality of points distributed along the time axis at a plurality of corresponding times. A color of each point of the plurality of points is defined in a plural-component color space and includes a first color component at a first intensity and a second color component at a second color component at a second intensity, and optionally a third color component at a third intensity when the plurality of time-series datasets includes a third time-series dataset.

Abstract: A method for providing a diagnosis and/or prognosis for a mitochondrial DNA (mtDNA) disorder or determining the risk of a mtDNA disorder developing in a subject, the method comprising the steps of assaying a stool sample from the subject to measure the level of mutated mtDNA molecules is provided. Methods for monitoring the progression of a mtDNA disorder, evaluating therapeutic effect of a treatment for a mtDNA disorder, and determining a subjects compliance with a prescribed treatment for a mtDNA disorder using a stool sample are also provided. Further, methods of treating a mtDNA disorder and uses of a stool sample in the methods described herein are also provided.

Abstract: The invention relates to compositions and methods of treatment employing compositions comprising polyelectrolyte complexes. The compositions include a water-soluble first polyelectrolyte bearing a net cationic charge or capable of developing a net cationic charge and a water-soluble second polyelectrolyte bearing a net anionic charge or capable of developing a net anionic charge. The total polyelectrolyte concentration of the first solution is at least 110 millimolar. The composition is free of coacervates, precipitates, latex particles, synthetic block copolymers, silicone copolymers, cross-linked poly(acrylic) and cross-linked water-soluble polyelectrolyte. The composition may be a concentrate, to be diluted prior to use to treat a surface.

Abstract: Purchasing, maintaining, and deriving revenue from mobile autonomous units is facilitated by providing a mobile autonomous unit marketplace in which equity shares in mobile autonomous units can be bought, sold and traded. Valuation of mobile autonomous units within the marketplace can be a function of a variety of factors such as the mobile autonomous unit's primary geographic region, and the number, diversity, and time management of revenue streams available to the mobile autonomous units.

Abstract: A clamp includes a closure mechanism and a band. The clamp can be a v-insert clamp. The band has a first metal layer and a second metal layer. The metal layers constitute a bi-metallic construction of the band. The metal layers can be composed of different stainless steel materials. The first metal layer possesses a first coefficient of thermal expansion, and the second metal layer possesses a second coefficient of thermal expansion. Values of the first coefficient of thermal expansion and of the second coefficient of thermal expansion differ relative to each other. The difference in value of the first and second coefficients of thermal expansion, and the position of the first and second metal layers relative to each other, can be effected in order to impart desired behavior of the band when experiencing a change in temperature.

Abstract: The present invention describes systems and methods for treating mitral valve regurgitation. The treatment includes a systems and method of modifying the mitral valve by attaching a device to each leaflet and pulling them toward each other to stop mitral valve regurgitation.

Abstract: The present disclosure provides systems, compositions, and methods for simultaneously editing both strands of a double-stranded DNA sequence at a target site to be edited. In some aspects, the systems comprise a first and second prime editor complex, wherein each of the first and second prime editor complexes comprises (1) a prime editor comprising (i) a nucleic acid programmable DNA binding protein (napDNAbp), and (ii) a polypeptide having an RNA-dependent DNA polymerase activity; and (2) a pegRNA comprising a spacer sequence, gRNA core, a DNA synthesis template, and a primer binding site, wherein the DNA synthesis template encodes a desired DNA sequence or a complement thereof, wherein the desired DNA sequence and the complement thereof form a duplex comprising an edited portion which integrates into the target site to be edited. In some aspects, the systems comprise a first, second, third, and fourth prime editor complex, each comprising a prime editor and a PEgRNA.

Abstract: Discussed herein are techniques that utilize hierarchical locality information of host machines included in a cluster network for the execution of general workloads. Hierarchical locality information for each host machine of a plurality of host machines is stored. The hierarchical locality information for a host machine identifying, for each locality of a plurality of localities, location information for the locality. Responsive to receiving a request requesting execution of a workload, the hierarchical locality information for the plurality of host machines is obtained and provided (e.g., to a customer) in response to the request.

Abstract: Method and systems of automated document processing described herein include activating in sequence a plurality of illumination modules of an illumination source to illuminate a document, where the plurality of illumination modules are located at different positions relative to the document. The document can be imaged each time the document is illuminated by an illumination module to provide a plurality of images. A shadow profile of the document can be obtained based on the plurality of images. One or more of a boundary of the document and presence of a fastener attached to the document can be identified using the shadow profile. Any fasteners present may be removed using a robot arm.

Abstract: A pipe union assembly that includes a female end of a first pipe section and a male end of a second pipe section. The pipe union assembly also includes a quick union nut securable to the female end, a retainer collar securable to the quick union nut and a segmented load ring disposed between the male end of the second pipe section and the quick union nut. The quick union nut, the retainer collar and the segmented load ring cooperate to maintain the male end of the second pipe section inside the female end of the first pipe section. A method of using the pipe union assembly to join a first pipe section and a second pipe section.

Abstract: A technique for handling memory access requests is described. An apparatus has an interconnect for coupling a plurality of requester elements with a plurality of slave elements. The requester elements are arranged to issue memory access requests for processing by the slave elements. An intermediate element within the interconnect acts as a point of serialisation to order the memory access requests issued by requester elements via the intermediate element. The intermediate element has tracking circuitry for tracking handling of the memory access requests accepted by the intermediate element. Further, request acceptance management circuitry is provided to identify a target slave element amongst the plurality of slave elements for that given memory access request, and to determine whether the given memory access request is to be accepted by the intermediate element dependent on an indication of bandwidth capability for the target slave element.

Abstract: Disclosed are methods and compositions for repolarizing a tumor associated macrophage (TAM) from M2 to M1 comprising administering to a subject in need thereof an effective dose of a compound comprising a dextran backbone and one or more CD206 targeting moieties conjugated thereto. In certain aspects, the compound further comprises a therapeutic agent selected from: paclitaxel, gemcitabine, lapatinib, and doxorubicin. In further aspect, the therapeutic agent comprises a chelator and at least one metal ion. In certain implementations, the at least one metal ion comprises at least one Cu(II) ions.

Abstract: An electrochemical cell includes a winding comprising a ribbon-shaped negative electrode with an anode current collector and a ribbon-shaped positive electrode with a cathode current collector. An assembly comprises the negative electrode and the positive electrode, the assembly is wound spirally around a winding axis to form the winding, the winding comprises a central cavity, two terminal end faces, and a circumferential winding shell. The electrochemical cell further includes a contact sheet metal member in direct contact with a protruding longitudinal edge of the anode current collector or the cathode current collector. In addition, the electrochemical cell includes a housing, a sensor apparatus configured detect changes in a state of the winding, and a display and/or a contact configured to display measured values and/or via which the measured values can be transmitted.