Abstract: Constructs, vectors, and methods for enhancing homology directed repair using the CRISPR/Cas9 gene editing platform are disclosed.

Abstract: Aspects of the subject disclosure may include, for example, a process that encodes a number of digital signals representing image data captured by a video camera, the image data being provided by the video camera in accordance with a 4K ultra-high definition (4K-UHD) standard. The number of digital signals are provided to a multiplexing unit that outputs a multiplexed signal including a number of optical wavelengths, the multiplexed signal being transmitted on a single fiber-optic cable unidirectionally from the multiplexing unit to a presentation device. The multiplexed signal is transmitted on the single cable unidirectionally from the proximal end to the distal end. Other embodiments are disclosed.

Abstract: A reconfigurable data processor comprises a bus system, and an array of configurable units connected to the bus system, configurable units in the array including configuration data stores to store unit files comprising a plurality of sub-files of configuration data particular to the corresponding configurable units. Configurable units in the plurality of configurable units each include logic to execute a unit configuration load process, including receiving via the bus system, sub-files of a unit file particular to the configurable unit, and loading the received sub-files into the configuration store of the configurable unit. A configuration load controller connected to the bus system, including logic to execute an array configuration load process, including distributing a configuration file comprising unit files for a plurality of the configurable units in the array.

Abstract: A method of authorizing a limited use intravascular device can include determining if the intravascular device is in communication with a clinical system; determining if the intravascular device is authorized for clinical operation without providing the clinical system access to intravascular device data stored on the intravascular device; and providing an authorization signal to the clinical system. An intravascular device can include a flexible elongate member including a sensing component at a distal portion and a connector at a proximal portion, the connector including: a memory component configured to store a parameter value; a processing component; and a charge storage component configured to power the memory component and/or the processing component; wherein the processing component is configured to determine if the flexible elongate member is authorized for clinical operation using the parameter value without providing the parameter value to a clinical system.

Abstract: Voltage supply system with boost converter and charge pump. A voltage supply system can include a boost converter controllable to receive an input voltage at an input node and generate an output voltage when the output voltage is greater than or equal to the input voltage. The voltage supply system can include a charge pump controllable to receive the input voltage at the input node and generate the output voltage when the output voltage is less than the input voltage. The voltage supply system can further include a controller configured to receive a control signal and control the boost converter or the charge pump to generate the output voltage at an output node based on the control signal.

Abstract: In accordance with embodiments, there are provided mechanisms and methods for creating, exporting, viewing and testing, and importing custom applications in a multitenant database environment. These mechanisms and methods can enable embodiments to provide a vehicle for sharing applications across organizational boundaries. The ability to share applications across organizational boundaries can enable tenants in a multi-tenant database system, for example, to easily and efficiently import and export, and thus share, applications with other tenants in the multi-tenant environment.

Abstract: A cart is disclosed for carrying a gas bottle. The cart includes a wheeled frame and a bottle support platform. The support platform is configured to pivot between a loading position in which a gas bottle may be loaded and/or unloaded from the bottle support platform and a cradle position in which the gas bottle and the bottle support platform are elevated. A bottle rest may support the bottle when the bottle support platform is in the cradle position. A bottle support spine may also, or alternatively, support the bottle during transportation and act as a lever for pivoting the bottle support platform between the loading position and the cradle position.

Abstract: Dislodgment of a constricting cord from an annulus can be prevented by delivering the distal loop portion of the constricting cord to the annulus using a percutaneous delivery tool, and launching anchors into the annulus so as to affix the distal loop portion of the constricting cord to the annulus. The percutaneous delivery tool is withdrawn in a proximal direction after the anchors have been launched. A pushing member is pressed in a distal direction so that the pushing member holds a portion of the constricting cord against the annulus with enough pressure to prevent dislodgment of any of the anchors during the withdrawal of the percutaneous delivery tool.

Abstract: The invention utilizes a two-component system to detect third party security threats and drive improved security threat mitigation based on the detection. The first component of the system is a security threat assessment engine, which receives and/or identifies external data and internal data regarding third parties in order to determine information security threats posed by third parties. The second component of the system is an analytics engine, which may comprise a machine learning component which is configured to detect threat patterns and anomalies. In response to the detection of the threat patterns and anomalies the security threat assessment engine may be modified in order to more accurately determine security threats.

Abstract: A method of and system for handling latency issues encountered in producing real-time entertainment such as games of skill synchronized with live or taped televised events is described herein. There are multiple situations that are dealt with regarding latencies in receiving a television signal with respect to real-time entertainment based on the unfolding games played along with the telecasts. Systemic delays, arbitrarily imposed delays of a broadcast signal and variances in the precise broadcast times of taped television programs have to be equalized so as to provide fair entertainment.

Abstract: A computing device includes technologies for securing indirect addresses (e.g., pointers) that are used by a processor to perform memory access (e.g., read/write/execute) operations. The computing device encodes the indirect address using metadata and a cryptographic algorithm. The metadata may be stored in an unused portion of the indirect address.

Abstract: A processor comprising a processor pipeline comprising one or more execution units configured to execute branch instructions, a branch predictor associated with the processor pipeline and configured to predict a branch instruction prediction outcome, and the branch prediction unit. The branch predictor is turned off to save power and avoid miss-predictions when the branch predictor and/or branch prediction unit accuracy is lower than expected.

Abstract: A method of manufacturing a pellicle for a lithographic apparatus, the method including locally heating the pellicle using radiative heating, and depositing coating material simultaneously on both sides of the pellicle, and pellicles manufactured according to this method. Also disclosed is the use of a multilayer graphene pellicle with a double-sided hexagonal boron nitride coating in a lithographic apparatus.

Abstract: Provided herein are compounds according to Formulas (I) or (II) and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, osteoarthritis, idiopathic pulmonary fibrosis and neurological conditions/disorders/diseases.

Abstract: There is provided a method and system for filling micromechanical structures with x-ray absorbing material. The method includes providing a wetting layer for enabling melted x-ray absorbing material to flow over the surface of an overall structure including the micromechanical structures, melting the x-ray absorbing material, and applying gas pressure to press the melted x-ray absorbing material into the micromechanical structures.

Abstract: Systems and methods for safe operation of a device include a control system having a memory and a processor coupled to the memory. The processor is configured to determine, using one or more sensors, whether an operator is in contact with an input control of a console coupled to the system. The processor is further configured to affect commanded motion of the device using the input control in response to the determination of operator contact with the input control. In some embodiments, affecting the commanded motion includes limiting commanded motion of the device using the input control in response to determining the operator is not in contact with the input control. In some embodiments, the limited commanded motion is an insertion motion of the elongate device, a retraction motion of the elongate device, or a steering motion of a distal end of the elongate device.

Abstract: An adapter that connects with a coupler for a wiper element is configured to connect with a plurality of different wiper arms each having a different wiper arm style. The adapter can be a one-piece body or a multi-piece body having a cavity and openings for receiving distal ends or distal end features of each of the plurality of different wiper arms. The adapter can also include different tabs for engaging with openings, notches or other components on distal ends of each of the plurality of different wiper arms.

Abstract: The invention relates to vaccines for the prevention or treatment of infectious diseases, and to methods of preparing or delivering such vaccines. In particular, a vaccine for use in the prevention or treatment of disease is used in a dose of, via a parenteral route without adjuvant less than 0.03 ?g antigen and with adjuvant less than 0.003 ?g antigen, and via a mucosal route without adjuvant less than 1 ?g antigen and/or the equivalent of 1.6×107 PFU and with adjuvant less than 0.04 ?g antigen and/or the equivalent of 1.

Abstract: A method or system for facilitating the determining and setting of stimulation parameters for programming an electrical stimulation system using closed loop programming is provided. For example, pulse generator feedback logic is executed by a processor to interface with control instructions of an implantable pulse generator by incorporating one or more machine learning engines to automatically generate a proposed set of stimulation parameter values that each affect a stimulation aspect of the implantable pulse generator, receive one or more clinical responses and automatically generate a revised set of values taking into account the received clinical responses, and repeating the automated receiving of a clinical response and adjusting the stimulation parameter values taking the clinical response into account, until or unless a stop condition is reach or the a therapeutic response is indicated within a designated tolerance.

Abstract: System and methods for presenting updated data using persisting views is disclosed. An example method comprises: identifying a first dataset and a second dataset; tracking updates to rows in each of the first dataset and the second dataset using a first local marker and a second local marker, respectively; performing a join between the first dataset and the second dataset; creating a materialized view using the join; identifying updates to one or more rows of the first dataset and the second dataset; identifying rows in the materialized view corresponding to the one or more rows of the first dataset and the second dataset with the identified updates, and updating, by one or more processing devices, the identified rows in the materialized view based on the identified updates to the one or more rows of the first dataset and the second dataset.