Patents by Inventor Davide Della Bella

Davide Della Bella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptides with pharmaceutical activity
    Patent number: 5145872
    Abstract: Compounds of the formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n have the meanings reported in the specification, processes for their preparation and pharmaceutical compositions containing them as active ingredient are described.The compounds of formula I are inhibitor of enzymatic systems and they are useful in pharmaceutical field.
    Type: Grant
    Filed: March 15, 1989
    Date of Patent: September 8, 1992
    Assignee: Zambon Group, S.p.A.
    Inventors: Dario Chiarino, Angelo Carenzi, Davide Della Bella, Franco Pellacini
  • Peptides with pharmaceutical activity
    Patent number: 5028626
    Abstract: Compounds of formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, and n have the meanings reported in the specification, processes for their preparation and pharmaceutical compositions containing them as active ingredient are described. The compounds of formula I are inhibitors of enzymatic systems and they are useful in pharmaceutical field.
    Type: Grant
    Filed: March 15, 1989
    Date of Patent: July 2, 1991
    Assignee: Zambon Group S.p.A.
    Inventors: Dario Chiarino, Angelo Carenzi, Davide Della Bella, Franco Pellacini
  • Isoxazoles with nootropic activity
    Patent number: 4985428
    Abstract: Nootropically active isoxazoles which are certain specified derivatives of N-(5-isoxazolecarbonyl)-4 aminobutyric acid.
    Type: Grant
    Filed: March 20, 1989
    Date of Patent: January 15, 1991
    Assignee: Zambon Group S.p.A.
    Inventors: Angelo Carenzi, Dario Chiarino, Davide Della Bella, Mauro Napoletano, Alberto Sala
  • Pyrrolidone-2 compounds and their use for central analgesic activity
    Patent number: 4960788
    Abstract: Compounds of formula ##STR1## (wherein R, R.sub.1, R.sub.2, R.sub.3 and n have the meanings reported in the specification), their salts with pharmaceutically acceptable acids, process for their preparation and pharmaceutical compositions containing them are described.The compounds of formula I have a remarkable analgesic activity.
    Type: Grant
    Filed: May 19, 1989
    Date of Patent: October 2, 1990
    Assignee: Zambon Group S.p.A.
    Inventors: Angelo Carenzi, Dario Chiarino, Davide Della Bella, Gian Carlo Grancini, Carlo Veneziani
  • Derivatives of thiazolidine-4-carboxylic acid having pharmacological activity
    Patent number: 4952596
    Abstract: Compounds of the formula ##STR1## wherien R, R.sub.1, R.sub.2 and Y have the meanings mentioned in the description, processes for their preparation and their use in the pharmaceutical field are described.The compounds of formula I are endowed with antipyretic, anti-inflammatory, mucolitic and analgesic activity together with good gastric tolerability.In addition, the compounds of formula I are active in the treatment of ischemic or reperfusion syndromes.
    Type: Grant
    Filed: December 21, 1988
    Date of Patent: August 28, 1990
    Assignee: Zambon S.p.A.
    Inventors: Davide Della Bella, Angelo Carenzi, Dario Chiarino, Franco Pellacini
  • Compositions with antibiotic activity and their use
    Patent number: 4918095
    Abstract: The compound N-[(1S,2R)-fluoromethyl-2-hydroxy-2-(4-methylsulphonyl-phenyl)-ethyl]-2-pr openamide and the derivatives thereof in which the hydroxy in 2 position is esterified by a mono or dicarboxylic acid or by an aminoacid are described.Such compounds have antibiotic activity and are useful in human and veterinary therapy.
    Type: Grant
    Filed: December 18, 1987
    Date of Patent: April 17, 1990
    Assignee: Zambon S.p.A.
    Inventors: Davide Della Bella, Giancarlo Jommi, Mario Fantucci, Dario Chiarino
  • Process for the preparaiton of alkyl fluorides
    Patent number: 4879068
    Abstract: Preparation of alkyl fluoride by replacement of an aliphatic hydroxy group with fluorine. The reaction is performed by treating a sulfonyl derivative of an aliphatic hydroxy group with an inorganic fluoride in a polyglycol.
    Type: Grant
    Filed: September 30, 1986
    Date of Patent: November 7, 1989
    Inventors: Dario Chiarino, Davide Della Bella, Giancarlo Jommi, Domenico Badone, Roberto Pagliarin, Paolo Tavecchia
  • Mono(2-ammonium-2-hydroxymethyl-1,3 propanediol)(2R-cis)-3-methyloxiranyl)phosphonate, its preparation and pharmaceutical compositions containing it
    Patent number: 4863908
    Abstract: Mono(2-ammonium-2-hydroxymethyl-1,3-propanediol)(2R-cis)-(3-methyloxiranyl) phosphonate endowed with therapeutic activity as broad-spectrum antibiotic, as well as a method for preparing same from bis(2-ammonium-2-hydroxymethyl-1,3-propanediol)(2R-cis)-(3-methyloxiranyl) phosphonate and a sulphonic acid. Pharmaceutical compositions containing the novel mono(2-ammonium-2-hydroxymethyl-1,3-propanediol)(2R-cis)-(3-methyloxiranyl ) phosphonate are disclosed.
    Type: Grant
    Filed: September 15, 1987
    Date of Patent: September 5, 1989
    Assignee: Zambon S.p.A.
    Inventors: Dario Chiarino, Davide Della Bella, Vittorio Ferrari
  • Pharmaceutically useful derivatives of thiazolidine-4-carboxylic acid
    Patent number: 4840936
    Abstract: Compounds of formula ##STR1## in which R, R.sub.1 and Y have the meanings shown in the description, their preparation by condensing an aldehyde or a ketone with cysteine or a derivative thereof and their use in the pharmaceutical field.The compounds of formula I possess antipyretic, anti-inflammatory, mucolytic and analgesic activity together with a low capacity to cause gastric injuries.The compounds of formula I, furthermore, are particularly useful in the treatment of ischemia and reperfusion syndromes.
    Type: Grant
    Filed: July 13, 1987
    Date of Patent: June 20, 1989
    Assignee: Zambon S.p.A.
    Inventors: Davide Della Bella, Angelo Carenzi, Dario Chiarino, Franco Pellacini
  • Thioesters for the treatment of ischemia and reperfusion syndromes
    Patent number: 4812477
    Abstract: A method for the treatment of ischemia and reperfusion syndromes, which consists in administering to a patient in need thereof a therapeutically effective amount of a compound of the formula: ##STR1## in which R is hydrogen or a C.sub.1 -C.sub.6 alkyl group, or of a salt thereof, when R=H, with a pharmaceutically acceptable base.New compounds and pharmaceutical compositions useful in the method of this invention.
    Type: Grant
    Filed: August 8, 1988
    Date of Patent: March 14, 1989
    Assignee: Zambon S.p.A.
    Inventors: Vittorio Ferrrari, Angelo Carenzi, Davide Della Bella
  • Method for the treatment of ischemia and reperfusion syndromes
    Patent number: 4806567
    Abstract: A method for the treatment of ischemia and reperfusion syndromes, which consists in administering to a patient in need thereof a therapeutically effective amount of a compound of the formula: ##STR1## in which R is hydrogen or a C.sub.1 -C.sub.6 alkyl group, or of a salt thereof, when R.dbd.H, with a pharmaeutically acceptable base.New compounds and pharmaceutical compositions useful in the method of this invention.
    Type: Grant
    Filed: July 13, 1987
    Date of Patent: February 21, 1989
    Assignee: Zambon S.p.A.
    Inventors: Vittorio Ferrari, Angelo Carenzi, Davide Della Bella
  • 4-(isoxazolyl)-thiazole-2-oxamic acids and derivatives thereof
    Patent number: 4766137
    Abstract: 4-(isoxazolyl)-thiazole-2-oxamic acids, esters and salts thereof; method for preparing them and intermediate compounds useful for their preparation.Said compounds possess antiallergic and antianaphylactic activity and may be used in the pharmaceutical field.Compositions for pharmaceutical use containing said compounds as the active ingredients are also described.
    Type: Grant
    Filed: March 13, 1986
    Date of Patent: August 23, 1988
    Assignee: Zambon S.p.A.
    Inventors: Angelo Carenzi, Dario Chiarino, Davide Della Bella, Giancarlo Grancini
  • Use of 4-(isoxazolyl)-thiazole-2-oxamic acid derivatives
    Patent number: 4766138
    Abstract: Use of 4-(isoxazolyl)-thiazole-2-oxamic acid derivatives; method for preparing them and intermediate compounds useful for their preparation.Said compounds possess antiarthritic activity; compositions for pharmaceutical use containing said compounds as the active ingredients are also described.
    Type: Grant
    Filed: March 13, 1986
    Date of Patent: August 23, 1988
    Assignee: Zambon S.p.A.
    Inventors: Angelo Carenzi, Dario Chiarino, Davide Della Bella, Giancarlo Grancini
  • Dipeptide compounds having pharmaceutical activity and compositions containing them
    Patent number: 4761399
    Abstract: The compounds of formula ##STR1## wherein the group ##STR2## represents the residue of a natural amino acid selected from the group consisting of glycine, alanine, beta-alanine, phenylalanine, isoleucine, methionine, proline, aspartic acid and arginine; R represents a hydrogen atom or a C.sub.1 -C.sub.4 alkyl; and their acid-addition salts with pharmaceutically acceptable organic or inorganic acids; are useful in the preventive and curative treatment of pathologic syndromes due to the lowering of glutathione (GSH) levels.
    Type: Grant
    Filed: August 11, 1986
    Date of Patent: August 2, 1988
    Assignee: Zambon S.p.A.
    Inventors: Alberto Pilotto, Mario Portelli, Angelo Carenzi, Davide Della Bella
  • Bis-(2-ammonium-2-hydroxymethyl-1,3-propaned iol(2R-cis)-(3-methyloxiranyl)-phosphonate, a method of preparing same, and pharmaceutical compositions containing same
    Patent number: 4727065
    Abstract: Bis-(2-ammonium-2-hydroxymethyl-1,3-propanediol)(2R-cis)-(3-methyloxiranyl) -phosphonate showing high bioavailability and tolerability is disclosed, as well as a method for preparing same from (2R-cis)-(3-methyloxiranyl)-phosphoric acid, or a salt thereof, and 2-amino-2-hydroxymethyl-1,3-propanediol, or a salt thereof. Pharmaceutical compositions containing the novel bis-phosphonate; useful for clinical forms of urinary and respiratory infections, are also disclosed.
    Type: Grant
    Filed: January 23, 1986
    Date of Patent: February 23, 1988
    Assignee: Zambon S.p.A.
    Inventors: Dario Chiarino, Davide Della Bella, Vittorio Ferrari
  • 1-(4-alkylthiophenyl)-2-(substituted or unsubstituted piperazine-1-yl)-1,3-propanediol, pharmaceutical compositions containing them useful as antiarrhythmic and vasodilating agents
    Patent number: 4638003
    Abstract: N-substituted derivatives of 1-(4'-alkylthiophenyl)-2-amino-1,3-propanediol, their salts with pharmaceutically acceptable organic and inorganic acids, processes for preparing them, pharmaceutical compositions containing them and intermediates useful in the preparation thereof.The novel derivatives according to this invention are endowed with calcium antagonist activity and are useful as antiarrhythmic and vasodilating agents.
    Type: Grant
    Filed: August 1, 1984
    Date of Patent: January 20, 1987
    Assignee: Zambon S.p.A.
    Inventors: Dario Chiarino, Angelo Carenzi, Davide Della Bella, Mario Fantucci
  • N-substituted 1-(4'-alkylsulfonylphenyl)-2-amino-1,3-propanediols, pharmaceutical compositions containing them, having local anesthetic activity
    Patent number: 4632940
    Abstract: N-substituted derivatives of 1-(4'-alkylsulfonylphenyl)-2-amino-1,3-propanediol, their salts with pharmaceutically acceptable organic and inorganic acids, processes for preparing them, pharmaceutical compositions containing them and intermediates useful in the preparation thereof.The novel derivatives according to this invention are endowed with local anesthetic activity.
    Type: Grant
    Filed: August 3, 1984
    Date of Patent: December 30, 1986
    Assignee: Zambon S.p.A.
    Inventors: Dario Chiarino, Angelo Carenzi, Davide Della Bella, Mario Fantucci
  • Method of treatment for inhibiting the tolerance onset while treating painful syndromes with central analgesics
    Patent number: 4575506
    Abstract: Thiamphenicol for use in the inhibition of tolerance onset while treating painful syndromes with central analgesics.
    Type: Grant
    Filed: November 1, 1984
    Date of Patent: March 11, 1986
    Assignee: Zambon S.p.A.
    Inventors: Davide Della Bella, Viviana Frigeni, Angelo Carenzi
  • Analgesic, antipyretic or anti-inflammatory imidazole compounds
    Patent number: 4560696
    Abstract: New imidazole compounds of the formula ##STR1## their salts and analgesic, antipyretic and antiinflammatory pharmaceutical composition containing them. New intermediates useful in the preparation of said imidazole compounds.Process for preparing the new imidazole compounds as well as some new intermediates for the preparation thereof.
    Type: Grant
    Filed: March 20, 1984
    Date of Patent: December 24, 1985
    Assignee: Zambon S.p.A.
    Inventors: Angelo Carenzi, Dario Chiarino, Davide Della Bella, Viviana Frigeni, Carlo Veneziani
  • Isoxazole derivatives
    Patent number: 4520200
    Abstract: A new isoxazole derivative and the preparation thereof are disclosed. 1-(3-Bromo-isoxazol-5-yl)-2-ter.butylaminoethanol endowed with therapeutic activity, in particular bronchodilating action is disclosed, as well as a method for preparing same from 3-bromo-5-isoxazolecarboxylic acid. New intermediate compounds as well as pharmaceutical compositions containing the novel isoxazole derivative are also disclosed.
    Type: Grant
    Filed: August 22, 1980
    Date of Patent: May 28, 1985
    Assignee: Zambon S.p.A.
    Inventors: Davide Della Bella, Dario Chiarino