Patents by Inventor Davide Zocco

Davide Zocco has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of hollow fibers to obtain blood or a blood derivative impoverished from blood cells and platelets derived extracellular vesicles
    Patent number: 12031892
    Abstract: A method is provided for using hollow fibers having a porosity above 20 nm, in particular polyethersulfone hollow fibers, to impoverish blood and blood-derivatives from blood-derived extracellular vesicles, in particular exosomes and exomers. Methods for obtaining and analyzing the impoverished samples are also provided.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: July 9, 2024
    Assignee: Medica S.P.A.
    Inventors: Antonio Chiesi, Natasa Zarovni, Davide Zocco
  • METHODS FOR PROCESSING AND ANALYZING CELL-DERIVED VESICLES
    Publication number: 20230383238
    Abstract: The present disclosure provides methods for processing cell-derived vesicles in which the cell-derived vesicles are not purified, prior to contacting with a fluorescent staining dye or an antibody. By utilizing a centrifugal filter, excess staining dye or antibody can be readily removed prior to analysis of one or more characteristics of the cell-derived vesicles. The methods provide rapid and simple processing and analysis, while maintaining a high concentration of cell-derived vesicles.
    Type: Application
    Filed: September 28, 2022
    Publication date: November 30, 2023
    Inventors: Davide ZOCCO, Ilaria PASSALACQUA, Shin Gyu BAE, Seung Wook OH, Jeong Eun PARK, Sung-Soo PARK, Hui-Chong LAU
  • METHODS FOR PROCESSING AND ANALYZING EXTRACELLULAR VESICLES
    Publication number: 20230100836
    Abstract: The present disclosure provides methods for processing extracellular vesicles in which the extracellular vesicles are not purified, prior to contacting with a fluorescent staining dye or an antibody. By utilizing a centrifugal filter, excess staining dye or antibody can be readily removed prior to analysis of one or more characteristics of the extracellular vesicles. The methods provide rapid and simple processing and analysis, while maintaining a high concentration of extracellular vesicles.
    Type: Application
    Filed: September 28, 2022
    Publication date: March 30, 2023
    Inventors: Davide ZOCCO, Mattia CRISCUOLI, Ilaria PASSALACQUA
  • Use of TM9SF4 as a biomarker for tumor associated exosomes
    Publication number: 20220349892
    Abstract: The present invention relates to extracellular microvesicles biomarkers for determining the tumour transformation status or presence of a tumour in a subject, and to the uses of such biomarkers and to diagnostics methods using such biomarkers. In particular, the methods and uses of the invention involve isolation of TM9SF4-positive extracellular vesicles and detection of the expression of a second biomarker, preferably selected from the group consisting of CD9 protein, miR-21 and RNU6.
    Type: Application
    Filed: May 5, 2022
    Publication date: November 3, 2022
    Inventors: Francesco LOZUPONE, Antonio Chiesi, Paolo Guazzi, Natasa Zarovni, Pietro Ferruzzi, Davide Zocco
  • USE OF HOLLOW FIBERS TO OBTAIN BLOOD OR A BLOOD DERIVATIVE IMPOVERISHED FROM BLOOD CELLS AND PLATELETS DERIVED EXTRACELLULAR VESICLES
    Publication number: 20210025795
    Abstract: A method is provided for using hollow fibers having a porosity above 20 nm, in particular polyethersulfone hollow fibers, to impoverish blood and blood-derivatives from blood-derived extracellular vesicles, in particular exosomes and exomers. Methods for obtaining and analyzing the impoverished samples are also provided.
    Type: Application
    Filed: March 29, 2019
    Publication date: January 28, 2021
    Inventors: Antonio CHIESI, Natasa ZAROVNI, Davide ZOCCO
  • METHODS AND KITS RELATING TO THE CAPTURE OF CA-IX POSITIVE EXOSOMES
    Publication number: 20200291482
    Abstract: Methods and kits for isolating tumour-derived exosomes by immunocapture with an anti CA-IX antibody, quantifying tumour-related nucleic acid sequences from the isolated exosomes and determining in vitro the presence of a tumour in a subject are provided.
    Type: Application
    Filed: June 21, 2018
    Publication date: September 17, 2020
    Applicant: EXOSOMICS S.P.A.
    Inventors: Antonio CHIESI, Natasa ZAROVNI, Davide ZOCCO
  • Use of TM9SF4 as a biomarker for tumor associated exosomes
    Publication number: 20170146543
    Abstract: The present invention relates to extracellular microvesicles biomarkers for determining the tumour transformation status or presence of a tumour in a subject, and to the uses of such biomarkers and to diagnostics methods using such biomarkers. In particular, the methods and uses of the invention involve isolation of TM9SF4-positive extracellular vesicles and detection of the expression of a second biomarker, preferably selected from the group consisting of CD9 protein, miR-21 and RNU6.
    Type: Application
    Filed: June 5, 2015
    Publication date: May 25, 2017
    Applicant: Exosomics Siena S.p.A.
    Inventors: Francesco LOZUPONE, Antonio Chiesi, Paolo Guazzi, Natasa Zarovni, Pietro Ferruzzi, Davide Zocco