Patents by Inventor Davinder Gill

Davinder Gill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200247911
    Abstract: The present invention relates to rapid purification of Neisseria meningitidis serogroup W and serogroup Y polysaccharides. The N. meningitidis polysaccharides of the present invention are capable of being used in the production of economical polysaccharide protein conjugate vaccine(s) against meningococcal infections.
    Type: Application
    Filed: April 27, 2018
    Publication date: August 6, 2020
    Inventors: Sandeep Sharma, Nitin KUMAR, Sarmad HANIF, Manoj Kumar CHHIKARA, Davinder GILL
  • Publication number: 20200147198
    Abstract: Novel multivalent polysaccharide-protein conjugate vaccine formulation. The formulation is liquid or lyophilized or a Liquid-Lyo combination pentavalent formulation of Neisseria meningitidis serogroup A, C, Y, W and X capsular polysaccharides (Men A, C, Y, W, X), each said polysaccharide being conjugated separately to tetanus toxoid (TT) carrier protein to obtain Men A, C, Y, W, X-TT conjugates, with one or more buffer and with or without an adjuvant along with pharmaceutically acceptable components/excipients.
    Type: Application
    Filed: April 26, 2018
    Publication date: May 14, 2020
    Inventors: Davinder Gill, Sandeep Sharma
  • Patent number: 10556000
    Abstract: The present invention relates to an improved thermostable spray dried rotavirus vaccine formulation and the process of preparing the same. More specifically the present invention discloses thermostable liquid, powder or granule-based rotavirus vaccine prepared using the spray drying process, such that the said vaccine has improved heat-stability, ease-of-use, ease-of-transportation and affordability features with significantly better chance of being adopted in developing and low income country's vaccination program.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: February 11, 2020
    Assignee: MSD WELLCOME TRUST HILLEMAN LABORATORIES PVT. LTD.
    Inventors: Davinder Gill, Nitin Saigal, Sachin Kale, Tarun Sharma, Nidhi Shukla, Deepa Sikriwal, Robert Evans
  • Patent number: 10532093
    Abstract: The present invention relates to a thermostable freeze dried rotavirus vaccine formulation and the process of preparing the same. More specifically the present invention discloses multivalent thermostable liquid, powder or cake based rotavirus vaccine formulation prepared using the freeze drying process, such that the said vaccine formulation possess improved heat-stability, easy to use and transport and highly affordable thereby meeting the requirements of developing and low income country's vaccination program. The said freeze dried rotavirus vaccine formulation along with reconstitution buffer is so engineered to be suitable for filling in appropriate packaging containers/ closures so designed such that they reduce the logistics requirement for storage.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: January 14, 2020
    Assignee: MDS WELLCOME TRUST HILLEMAN LABORATORIES PVT. LTD.
    Inventors: Davinder Gill, Madhu Madan, Sachin Kale, Tarun Sharma, Nidhi Shukla, Deepa Sikriwal, Robert Evans
  • Patent number: 10183962
    Abstract: The present invention relates to synthesis of novel higher oligomers and process of preparing the same. In particular the present invention relates to the chemical synthesis of oligomers of Neisseria meningitidis serogroup X (‘hereinafter Men-X), more particularly tetramer. The present invention provides Men-X capsular oligomers obtained from synthetic pathway using purified saccharides of specific chain length and provides said novel oligomers as candidates for the development of conjugate vaccine against bacterial meningitis caused due to Men-X infections.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: January 22, 2019
    Assignee: MSD WELLCOME TRUST HILLEMAN LABORATORIES PVT. LTD.
    Inventors: Davinder Gill, Kishore Harale, Manoj Kumar Chhikara
  • Publication number: 20180360944
    Abstract: The present invention relates to a novel process of production of purified recombinant cholera toxin B (rCTB) which provides protection against diarrhea caused by various bacteria such as Vibrio cholerae and Enterotoxigenic Escherichia coli (ETEC). More particularly, the present invention relates to a process of production of rCTB with significantly higher yield and higher purity. The present invention also relates to a vaccine formulation having synergistic protection against Vibrio cholerae and cross protection against ETEC.
    Type: Application
    Filed: December 9, 2016
    Publication date: December 20, 2018
    Inventors: Tarun SHARMA, Neeraj JOSHI, Vibhu KANCHAN, Deepa SIKRIWAL, Nidhi SHUKLA, Davinder GILL
  • Patent number: 10105438
    Abstract: The present invention relates to an improved process of conjugation to obtain synthetic oligosaccharide-protein (OS-PR) conjugates. The process of synthetic OS-PR conjugation is a rapid process providing oligosaccharide-protein conjugates which are highly immunogenic and elicit specific and homogenous immune responses. The synthetic oligosaccharide comprising of four to eight repeating units of respective monomers and at least one in-built terminal amino linker, said synthetic polysaccharide mimics natural polysaccharide obtained from gram negative bacteria such as Neisseria meningitidis serogroups A, C, Y, W, X and Haemophilus influenzae and carrier protein is obtained from gram positive bacteria such as Clostridium tetani (tetanus toxoid) or Corynebacterium diphtheriae (CRM197) or their recombinant versions. The conjugation chemistry of the said oligosaccharide-protein conjugate of the present invention is thio-ether linkage. The present invention takes complete process time in the range of 14-22 hours.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: October 23, 2018
    Assignee: MSD WELLCOME TRUST HILLEMAN LABORATORIES PVT. LTD.
    Inventors: Davinder Gill, Manoj Kumar Chhikara, Rakesh Rana, Juned Dalal, Deepti Singh
  • Patent number: 10011662
    Abstract: The present invention relates to a novel process for purifying bacterial polysaccharide. It is an efficient and scalable process for removing impurities from Neisseria meningitidis serogroup C (Men-C) polysaccharide which is capable of being used as such in a derivatized form or linked to other molecules, for the preparation of vaccines, more particularly conjugate vaccines for N. meningitidis infection.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: July 3, 2018
    Assignee: MSD WELLCOME TRUST HILLEMAN LABORATORIES PVT. LTD.
    Inventors: Davinder Gill, Manoj Kumar Chhikara, Sandeep Sharma, Sarmad Hanif, Neeraj Joshi
  • Publication number: 20180162937
    Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.
    Type: Application
    Filed: January 30, 2018
    Publication date: June 14, 2018
    Applicant: WYETH LLC
    Inventors: Erwin R. BOGHAERT, Nitin K. DAMLE, Philip Ross HAMANN, Kiran KHANDKE, Arthur KUNZ, Kimberly A. MARQUETTE, Lioudmila TCHISTIAKOVA, Davinder GILL, Sreekumar R. KODANGATTIL
  • Patent number: 9902771
    Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: February 27, 2018
    Assignee: WYETH LLC
    Inventors: Erwin R. Boghaert, Nitin K. Damle, Philip Ross Hamann, Kiran Khandke, Arthur Kunz, Kimberly A. Marquette, Lioudmila Tchistiakova, Davinder Gill, Sreekumar R. Kodangattil
  • Publication number: 20170246313
    Abstract: The present invention relates to an improved process of conjugation to obtain synthetic oligosaccharide-protein (OS-PR) conjugates. The process of synthetic OS-PR conjugation is a rapid process providing oligosaccharide-protein conjugates which are highly immunogenic and elicit specific and homogenous immune responses. The synthetic oligosaccharide comprising of four to eight repeating units of respective monomers and at least one in-built terminal amino linker, said synthetic polysaccharide mimics natural polysaccharide obtained from gram negative bacteria such as Neisseria meningitidis serogroups A, C, Y, W, X and Haemophilus influenzae and carrier protein is obtained from gram positive bacteria such as Clostridium tetani (tetanus toxoid) or Corynebacterium diphtheriae (CRM197) or their recombinant versions. The conjugation chemistry of the said oligosaccharide-protein conjugate of the present invention is thio-ether linkage. The present invention takes complete process time in the range of 14-22 hours.
    Type: Application
    Filed: October 8, 2015
    Publication date: August 31, 2017
    Inventors: Davinder GILL, Manoj Kumar CHHIKARA, Rakesh RANA, Juned DALAL, Deepti SINGH
  • Publication number: 20170173145
    Abstract: The present invention relates to an improved thermostable spray dried rotavirus vaccine formulation and the process of preparing the same. More specifically the present invention discloses thermostable liquid, powder or granule-based rotavirus vaccine prepared using the spray drying process, such that the said vaccine has improved heat-stability, ease-of-use, ease-of-transportation and affordability features with significantly better chance of being adopted in developing and low income country's vaccination program.
    Type: Application
    Filed: July 17, 2015
    Publication date: June 22, 2017
    Inventors: Davinder Gill, Nitin SAIGAL, Sachin KALE, Tarun SHARMA, Nidhi SHUKLA, Deepa SIKRIWAL, Robert EVANS
  • Publication number: 20170165354
    Abstract: The present invention relates to a thermostable freeze dried rotavirus vaccine formulation and the process of preparing the same. More specifically the present invention discloses multivalent thermostable liquid, powder or cake based rotavirus vaccine formulation prepared using the freeze drying process, such that the said vaccine formulation possess improved heat-stability, easy to use and transport and highly affordable thereby meeting the requirements of developing and low income country's vaccination program. The said freeze dried rotavirus vaccine formulation along with reconstitution buffer is so engineered to be suitable for filling in appropriate packaging containers/ closures so designed such that they reduce the logistics requirement for storage.
    Type: Application
    Filed: July 16, 2015
    Publication date: June 15, 2017
    Inventors: Davinder Gill, Madhu MADAN, Sachin KALE, Tarun SHARMA, Nidhi SHUKLA, Deepa SIKRIWAL, Robert EVANS
  • Patent number: 9644025
    Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: May 9, 2017
    Assignees: WYETH LLC, JANSSEN SCIENCES IRELAND UC
    Inventors: Ronald Black, Lars Ekman, Ivan Lieberburg, Michael Grundman, James Callaway, Keith M. Gregg, Jack Steven Jacobsen, Davinder Gill, Lioudmila Tchistiakova, Angela Widom
  • Publication number: 20170066794
    Abstract: The present invention relates to synthesis of novel higher oligomers and process of preparing the same. In particular the present invention relates to the chemical synthesis of oligomers of Neisseria meningitidis serogroup X (‘hereinafter Men-X), more particularly tetramer. The present invention provides Men-X capsular oligomers obtained from synthetic pathway using purified saccharides of specific chain length and provides said novel oligomers as candidates for the development of conjugate vaccine against bacterial meningitis caused due to Men-X infections.
    Type: Application
    Filed: February 24, 2015
    Publication date: March 9, 2017
    Inventors: Davinder GILL, Kishore HARALE, Manoj Kumar CHHIKARA
  • Publication number: 20170051080
    Abstract: The present invention relates to a novel process for purifying bacterial polysaccharide. It is an efficient and scalable process for removing impurities from Neisseria meningitidis serogroup C (Men-C) polysaccharide which is capable of being used as such in a derivatized form or linked to other molecules, for the preparation of vaccines, more particularly conjugate vaccines for N. meningitidis infection.
    Type: Application
    Filed: February 24, 2015
    Publication date: February 23, 2017
    Inventors: Davinder GILL, Manoj Kumar CHHIKARA, Sandeep SHARMA, Sarmad HANIF, Neeraj JOSHI
  • Publication number: 20160185859
    Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.
    Type: Application
    Filed: December 16, 2015
    Publication date: June 30, 2016
    Applicant: WYETH LLC
    Inventors: Erwin R. BOGHAERT, Nitin K. DAMLE, Philip Ross HAMANN, Kiran KHANDKE, Arthur KUNZ, Kimberly A. MARQUETTE, Lioudmila TCHISTIAKOVA, Davinder GILL, Sreekumar R. KODANGATTIL
  • Patent number: 9272030
    Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered is monitored by measuring levels of tau.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: March 1, 2016
    Assignees: JANSSEN SCIENCES IRELAND UC, WYETH LLC
    Inventors: Ronald Black, Jack Steven Jacobsen, Lioudmila Tchistiakova, Angela Widom, Davinder Gill, Lars Ekman, Ivan Lieberburg, Michael Grundman, James Callaway, Keith M. Gregg, Wagner Zago, Manuel J. Buttini, Gene G. Kinney
  • Publication number: 20150118223
    Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered is monitored by measuring levels of tau.
    Type: Application
    Filed: April 22, 2011
    Publication date: April 30, 2015
    Applicants: WYETH LLC, JANSSEN ALZHEIMER IMMUNOTHERAPY
    Inventors: Ronald Black, Jack Steven Jacobsen, Lioudmila Tchistiakova, Angela Widom, Davinder Gill, Lars Ekman, Ivan Lieberburg, Michael Grundman, James Callaway, Keith M. Gregg, Wagner Zago, Manuel J. Buttini, Gene G. Kinney
  • Publication number: 20140308302
    Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.
    Type: Application
    Filed: May 29, 2014
    Publication date: October 16, 2014
    Inventors: Erwin R. BOGHAERT, Nitin K. DAMLE, Philip Ross HAMANN, Kiran KHANDKE, Arthur KUNZ, Kimberly A. MARQUETTE, Lioudmila TCHISTIAKOVA, Davinder GILL, Kodangattil R. SREEKUMAR