Patents by Inventor Davoud Mozhdehi

Davoud Mozhdehi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-canonical lipoproteins with programmable assembly and architecture and method of making non-canonical lipoproteins
    Patent number: 11884941
    Abstract: Artificial lipoproteins bearing non-canonical post-translational modifications that are synthesized by leveraging substrate promiscuity of an acyltransferase. The non-canonical functionality of these lipoprotein results in a distinctive hysteretic assembly that is absent from the canonical lipoproteins and is used to prepare hybrid multiblock materials with precise and programmable patterns of amphiphilicity due to the unique assembly and function of the non-canonical post-translational modifications.
    Type: Grant
    Filed: November 18, 2021
    Date of Patent: January 30, 2024
    Assignee: SYRACUSE UNIVERSITY
    Inventor: Davoud Mozhdehi
  • ADAPTIVE RECOMBINANT NANOWORMS FROM GENETICALLY ENCODABLE STAR AMPHIPHILES
    Publication number: 20230192766
    Abstract: A programmable assembly of proteins into well-defined nanoworms with broadened stability regimes is disclosed. Posttranslational modifications (PTMs) were used to generate lipidated proteins with precise topological and compositional asymmetry. Using an integrated experimental and computational approach, the material properties (thermoresponse and nanoscale assembly) of these hybrid amphiphiles are modulated by their amphiphilic architecture. The judicious choice of amphiphilic architecture can be used to program the assembly of proteins into adaptive nanoworms that undergo a morphological transition (sphere-to-nanoworms) in response to temperature stimuli.
    Type: Application
    Filed: November 8, 2022
    Publication date: June 22, 2023
    Applicant: SYRACUSE UNIVERSITY
    Inventors: Davoud Mozhdehi, Md Shahadat Hossain
  • Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
    Patent number: 11648200
    Abstract: Disclosed herein are conjugates including a fatty acid, a self-assembly domain, and a polypeptide, where the conjugates have phase transition behavior. Further disclosed are methods of using the conjugates to treat disease, methods of delivering an agent, and methods of preparing the conjugates.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: May 16, 2023
    Assignee: Duke University
    Inventors: Ashutosh Chilkoti, Davoud Mozhdehi, Kelli M. Luginbuhl
  • Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
    Patent number: 11554097
    Abstract: Disclosed herein are conjugates including a fatty acid, a self-assembly domain, and a polypeptide having phase transition behavior. Further disclosed are methods of using the conjugates to treat disease, methods of delivering an agent, and methods of preparing the conjugates.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: January 17, 2023
    Assignee: Duke University
    Inventors: Ashutosh Chilkoti, Kelli Luginbuhl, Davoud Mozhdehi
  • NON-CANONICAL LIPOPROTEINS WITH PROGRAMMABLE ASSEMBLY AND ARCHITECTURE
    Publication number: 20220154151
    Abstract: Artificial lipoproteins bearing non-canonical post-translational modifications that are synthesized by leveraging substrate promiscuity of an acyltransferase. The non-canonical functionality of these lipoprotein results in a distinctive hysteretic assembly that is absent from the canonical lipoproteins and is used to prepare hybrid multiblock materials with precise and programmable patterns of amphiphilicity due to the unique assembly and function of the non-canonical post-translational modifications.
    Type: Application
    Filed: November 18, 2021
    Publication date: May 19, 2022
    Applicant: SYRACUSE UNIVERSITY
    Inventor: Davoud Mozhdehi
  • RECOMBINANT PRODUCTION OF HYBRID LIPID-BIOPOLYMER MATERIALS THAT SELF-ASSEMBLE AND ENCAPSULATE AGENTS
    Publication number: 20210154143
    Abstract: Disclosed herein are conjugates including a fatty acid, a self-assembly domain, and a polypeptide having phase transition behavior. Further disclosed are methods of using the conjugates to treat disease, methods of delivering an agent, and methods of preparing the conjugates.
    Type: Application
    Filed: May 15, 2018
    Publication date: May 27, 2021
    Inventors: Ashutosh Chilkoti, Kelli Luginbuhl, Davoud Mozhdehi
  • GENETICALLY ENCODED LIPID-POLYPEPTIDE HYBRID BIOMATERIALS THAT EXHIBIT TEMPERATURE TRIGGERED HIERARCHICAL SELF-ASSEMBLY
    Publication number: 20190328662
    Abstract: Disclosed herein are conjugates including a fatty acid, a self-assembly domain, and a polypeptide, where the conjugates have phase transition behavior. Further disclosed are methods of using the conjugates to treat disease, methods of delivering an agent, and methods of preparing the conjugates.
    Type: Application
    Filed: January 12, 2018
    Publication date: October 31, 2019
    Inventors: Ashutosh Chilkoti, Davoud Mozhdehi, Kelli M. Luginbuhl