Abstract: The invention relates to mutant nuclear hormone receptors that encode mutant nuclear hormone receptors, in which particular amino acid residues are substituted with respect to wild type, so as to be able to detect ligand binding to the mutant receptor by either a change in a physical property of the mutant receptor and/or an transcriptional induction of a nuclear hormone receptor construct. The invention also relates to a nuclear hormone receptor response element denoted by the formula YDRXZ comprising a direct repeat (DR) comprising two half sites separated by X nucleic acid bases; wherein Z indicates the presence of at least one DR oriented in either a forward or reverse orientation; wherein Y equals 1 to 8 forward and/or reverse direct repeats; and X equals 1 to about 12.

Abstract: The invention relates to mutant nuclear hormone receptors that encode mutant nuclear hormone receptors, in which particular amino acid residues are substituted with respect to wild type, so as to be able to detect ligand binding to the mutant receptor by either a change in a physical property of the mutant receptor and/or an transcriptional induction of a nuclear hormone receptor construct. The invention also relates to a nuclear hormone receptor response element denoted by the formula YDRXZ comprising a direct repeat (DR) comprising two half sites separated by X nucleic acid bases; wherein Z indicates the presence of at least one DR oriented in either a forward or reverse orientation; wherein Y equals 1 to 8 forward and/or reverse direct repeats; and X equals 1 to about 12.

Abstract: A sliding contact bearing, especially an aircraft landing gear trunnion beating, comprises two bearing members (1, 3) composed of titanium or titanium alloy with cooperating sliding surfaces (2, 4), a first one of which is chromium plated and the second one of which is coated with nickel and fluorocarbon polymer. Preferably, the nickel coating is applied by an electroless plating process, and the fluorocarbon is infused into pores in the nickel plating. Preferably, the nickel and fluorocarbon coating is 0.025 to 0.041 mm thick, and has a hardness in the range 750-1000 VPN.