Patents by Inventor Daw-long Kwok

Daw-long Kwok has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR PREPARING ALPHA-CARBOXAMIDE PYRROLIDINE DERIVATIVES
    Publication number: 20220356154
    Abstract: The disclosure relates to novel processes for preparing ?-carboxamide pyrrolidine derivatives, in particular (2S, 5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide, and to novel intermediates for use in said process along with processes for preparing said intermediates.
    Type: Application
    Filed: November 24, 2021
    Publication date: November 10, 2022
    Inventors: Weirong Chen, Vinny Couming, Erwin Irdam, William F. Kiesman, Daw-long A. Kwok, Tamera L. Mack, Suzanne M. Opalka, Daniel B. Patience, Donald G. Walker, Wenli Liang
  • Novel Crystalline Forms
    Publication number: 20220098150
    Abstract: The present invention is directed to novel crystalline forms of 5-(4-{[2-fluorophenyl)methyl]oxy}phenyl-prolinamide hydrochloride, to the use of said crystalline forms in treating diseases and conditions mediated by modulation of voltage-gated sodium channels, to compositions containing said crystalline forms and processes for their preparation.
    Type: Application
    Filed: May 17, 2021
    Publication date: March 31, 2022
    Inventors: Nishanth Gopinathan, Erwin Irdam, William Kiesman, Daw-long A. Kwok, Yiqing Lin, Frederick Osei-Yeboah, Matthew Peterson, Kenny Tran, Kalyan Vasudevan
  • Process for preparing alpha-carboxamide pyrrolidine derivatives
    Patent number: 11192856
    Abstract: The invention relates to a novel process for preparing a-carboxamide pyrrolidine derivatives, in particular (2S, 5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide, and to novel intermediates for use in said process along with processes for preparing said intermediates.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: December 7, 2021
    Assignee: Biogen Inc.
    Inventors: Weirong Chen, Vinny Couming, Erwin Irdam, William F. Kiesman, Daw-Long A. Kwok, Tamera L. Mack, Suzanne M. Opalka, Daniel B. Patience, Donald G. Walker, Wenli Liang
  • PROCESS FOR PREPARING ALPHA-CARBOXAMIDE PYRROLIDINE DERIVATIVES
    Publication number: 20200270206
    Abstract: The invention relates to a novel process for preparing a-carboxamide pyrrolidine derivatives, in particular (2S, 5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide, and to novel intermediates for use in said process along with processes for preparing said intermediates.
    Type: Application
    Filed: October 5, 2018
    Publication date: August 27, 2020
    Inventors: Weirong Chen, Vinny Couming, Erwin Irdam, William F. Kiesman, Daw-long A. Kwok, Tamera L. Mack, Suzanne M. Opalka, Daniel B. Patience, Donald G. Walker, Wenli Liang
  • NOVEL CRYSTALLINE FORMS
    Publication number: 20200062705
    Abstract: The present invention is directed to novel crystalline forms of 5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-prolinamide hydrochloride, to the use of said crystalline forms in treating diseases and conditions mediated by modulation of voltage-gated sodium channels, to compositions containing said crystalline forms and processes for their preparation.
    Type: Application
    Filed: May 18, 2018
    Publication date: February 27, 2020
    Inventors: Nishanth Gopinathan, Erwin Irdam, William Kiesman, Daw-long A. Kwok, Yiqing Lin, Frederick Osei-Yeboah, Matthew Peterson, Kenny Tran, Kalyan Vasudevan
  • Exo- and diastereo-selective synthesis of himbacine analogs
    Patent number: 8618314
    Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: December 31, 2013
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: George G. Wu, Anantha Sudhakar, Tao Wang, Ji Xie, Frank X. Chen, Marc Poirier, Mingsheng Huang, Vijay Sabesan, Daw-long Kwok, Jian Cui, Xiaojing Yang, Tiruvettipuram K. Thiruvengadam, Jing Liao, Illia Zavialov, Hoa N. Nguyen, Ngiap Kie Lim
  • EXO- AND DIASTEREO- SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS
    Publication number: 20120296093
    Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.
    Type: Application
    Filed: July 31, 2012
    Publication date: November 22, 2012
    Inventors: George Wu, Anantha R. SUDHAKAR, Tao WANG, Ji XIE, Frank Xing CHEN, Marc POIRIER, Mingsheng HUANG, Vijay SABESAN, Daw-long KWOK, Jian CUI, Xiaojing YANG, Tiruvettipuram K. THIRUVENGADAM, Jing LIAO, Ilia A. Zavialov, Hoa N. NGUYEN, Ngiap Kie LIM
  • Exo- and diastereo- selective synthesis of himbacine analogs
    Patent number: 8258319
    Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: September 4, 2012
    Assignee: Schering Corporation
    Inventors: George G. Wu, Anantha Sudhakar, Tao Wang, Ji Xie, Frank X. Chen, Marc Poirier, Mingsheng Huang, Vijay Sabesan, Daw-long Kwok, Jian Cui, Xiaojing Yang, Tiruvettipuram K. Thiruvengadam, Jing Liao, Ilia Zavialov, Hoa N. Nguyen, Ngiap Kie. Lim
  • Exo-selective synthesis of himbacine analogs
    Patent number: 8138180
    Abstract: This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: March 20, 2012
    Assignee: Schering Corporation
    Inventors: Tiruvettipuram K. Thiruvengadam, Anantha Sudhakar, Ngiap Kie Lim, Daw-long Kwok, George G. Wu, Tao Wang, Mingsheng Huang, Michael D. Green
  • EXO- AND DIASTEREO- SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS
    Publication number: 20110251392
    Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.
    Type: Application
    Filed: June 24, 2011
    Publication date: October 13, 2011
    Inventors: George Wu, Anantha R. Sudhakar, Mingsheng Huang, Tao Wang, Vijay Sabesan, Ji Xie, Frank Xing Chen, Marc Poirier, Daw-long Kwok, Jian Cui, Xiaojing Yang, Tiruvettipuram K. Thiruvengadam, Jing Liao, Ilia A. Zavialov, Hoa N. Nguyen, Ngiap Kie. Lim
  • DEHYDROHALOGENATION PROCESS FOR THE PREPARATION OF INTERMEDIATES USEFUL IN PROVIDING 6,6-DIMETHYL-3-AZABICYCLO-[3.1.0]- HEXANE COMPOUNDS
    Publication number: 20110092716
    Abstract: The present invention provides for a process for preparing the pyrrole compounds of Formula Va and Vb.
    Type: Application
    Filed: November 20, 2008
    Publication date: April 21, 2011
    Inventors: Daw-long Kwok, Hong-Chang Lee, Ilia A. Zavialov
  • EXO-SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS
    Publication number: 20100267947
    Abstract: This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists.
    Type: Application
    Filed: June 30, 2010
    Publication date: October 21, 2010
    Applicant: SCHERING CORPORATION
    Inventors: Tiruvettipuram K. Thiruvengadam, Anantha R. Sudhakar, Ngiap Kie Lim, Daw-long Kwok, George G. Wu, Tao Wang, Mingsheng Huang, Michael D. Green
  • Exo-selective synthesis of himbacine analogs
    Patent number: 7772276
    Abstract: This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: August 10, 2010
    Assignee: Schering Corporation
    Inventors: Tiruvettipuram K. Thiruvengadam, Anantha R. Sudhakar, Ngiap-Kie Lim, Daw-long Kwok, George G. Wu, Tao Wang, Mingsheng Huang, Michael D. Green
  • Process and intermediates for the preparation of (1,2,5)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof
    Patent number: 7728165
    Abstract: In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
    Type: Grant
    Filed: June 15, 2009
    Date of Patent: June 1, 2010
    Assignee: Schering Plough Corporation
    Inventors: Jeonghan Park, Anantha R Sudhakar, George S. K. Wong, Minzhang Chen, Juergen Weber, Xiaojing Yang, Daw-long Kwok, Ingyu Jeon, Ramani R Raghavan, Maria Tamarez, Weidong Tong, Eugene J. Vater
  • EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS
    Publication number: 20090281321
    Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.
    Type: Application
    Filed: July 17, 2009
    Publication date: November 12, 2009
    Inventors: George Wu, Anantha R. Sudhakar, Tao Wang, Ji Xie, Frank Xing Chen, Marc Poirier, Mingsheng Huang, Vijay Sabesan, Daw-long Kwok, Jian Cui, Xiaojing Yang, Tiruvettipuram K. Thiruvengadam, Jing Liao, Ilia A. Zavialov, Hoa N. Nguyen, Ngiap Kie Lim
  • Exo- and diastereo- selective syntheses of himbacine analogs
    Patent number: 7605275
    Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: October 20, 2009
    Assignee: Schering Corporation
    Inventors: Frank Xing Chen, Marc Poirier, Mingsheng Huang, Vijay Sabesan, George Wu, Anantha R. Sudhakar, Tao Wang, Ji Xie, Jing Liao, Ilia A. Zavialov, Hoa N. Nguyen, Ngiap Kie Lim, Daw-long Kwok, Jian Cui, Xiaojing Yang, Tiruvettipuram K. Thiruvengadam
  • Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates for salts thereof
    Patent number: 7569705
    Abstract: In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I.
    Type: Grant
    Filed: November 6, 2007
    Date of Patent: August 4, 2009
    Assignee: Schering Corporation
    Inventors: Jeonghan Park, Anantha R Sudhakar, George S. K. Wong, Minzhang Chen, Juergen Weber, Xiaojing Yang, Daw-long Kwok, Ingyu Jeon, Ramani R Raghavan, Maria Tamarez, Weidong Tong, Eugene J. Vater
  • Exo- and diastereo- selective syntheses of himbacine analogs
    Publication number: 20060247450
    Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.
    Type: Application
    Filed: January 12, 2006
    Publication date: November 2, 2006
    Inventors: George Wu, Anantha Sudhakar, Tao Wang, Ji Xie, Frank Chen, Marc Poirier, Mingsheng Huang, Vijay Sabesan, Daw-long Kwok, Jian Cui, Xiaojing Yang, Tiruvettipuram Thiruvengadam, Jing Liao, Ilia Zavialov, Hoa Nguyen, Ngiap Lim
  • Exo-selective synthesis of himbacine analogs
    Publication number: 20060217422
    Abstract: This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists.
    Type: Application
    Filed: January 12, 2006
    Publication date: September 28, 2006
    Inventors: Tiruvettipuram Thiruvengadam, Anantha Sudhakar, Ngiap Lim, Daw-long Kwok, George Wu, Tao Wang, Mingsheng Huang, Michael Green