Abstract: The present invention relates to the protection against malaria. More particularly, the invention pertains to a novel family of genes encompassing the already known MSP-3 gene, and showing exceptional redundancy of exposed epitopes, hence suggesting that this family of genes plays an important part in the immunogenicity of the parasite. The characterization of this gene family enables the definition of novel immunogenic and vaccine compositions against P. falciparum. The invention also relates to an antigenic polypeptidic composition, comprising at least one MSP-3-b-like motif and at least one MSP-3-c/d-like motif.