Abstract: The disclosure relates to KRASG12D inhibitor compounds having the structure of Formula (A) or Formula (B), pharmaceutical compositions thereof, and methods of use thereof for inhibiting, treating, and/or preventing KRASG12D mutation-associated diseases, disorders and conditions.

Abstract: Provided herein are methods, systems, and non-transitory computer-readable media of providing a predicted rate based on information about the property, the customer, and the amenities that a supplier has proposed. The rate may be based on many factors that can be extracted or derived from the historical bid data, including, but not limited to: location and market tier of the property, length of relationship with the channel (which may be an account or customer), the included amenities, the cancellation policy, the size of the account's or channel's event, the season of the booking, the proximity of the channel's offices of the account or channel to the property. Increased confidence that a customer is getting a fair rate facilitates negotiations between contracting parties.

Abstract: Provided herein are methods, systems, and non-transitory computer-readable media of providing a predicted rate based on information about the property, the customer, and the amenities that a supplier has proposed. The rate may be based on many factors that can be extracted or derived from the historical bid data, including, but not limited to: location and market tier of the property, length of relationship with the channel (which may be an account or customer), the included amenities, the cancellation policy, the size of the account's or channel's event, the season of the booking, the proximity of the channel's offices of the account or channel to the property. Increased confidence that a customer is getting a fair rate facilitates negotiations between contracting parties.

Abstract: A system for constructing a virtual 3D model of one or more objects within a scene, where the virtual 3D model contains one or more flat faces on each object constructed. In some embodiments, the system may include at least one processing device configured to: receive, through a data interface, data describing a set of measurements of observed portions of the one or more objects in the scene, where the set of measurements was performed by one or more measurement devices; receive, through a data interface or user input device, one or more shape definitions, where the shape definitions define the possible shapes of a virtual 3D model of an object, and where the virtual 3D model of an object is to be constructed from the measurement data, and where the shapes contain one or more regions with primitive geometries.

Abstract: A system for constructing a virtual 3D model of one or more objects within a scene, where the virtual 3D model contains one or more flat faces on each object constructed. In some embodiments, the system may include at least one processing device configured to: receive, through a data interface, data describing a set of measurements of observed portions of the one or more objects in the scene, where the set of measurements was performed by one or more measurement devices; receive, through a data interface or user input device, one or more shape definitions, where the shape definitions define the possible shapes of a virtual 3D model of an object, and where the virtual 3D model of an object is to be constructed from the measurement data, and where the shapes contain one or more regions with primitive geometries.