Abstract: The present disclosure provides a C6?-substituted locked nucleic acid-modified cap analog and a use thereof, wherein the cap analog improves the stability of mRNA and/or the translation efficiency of mRNA.

Abstract: Provided in the present disclosure is a compound of formula (I), or an N-oxide, solvate, pharmaceutically acceptable salt or stereoisomer thereof, which is an extrahepatic targeted cationic lipid compound with high efficiency and low toxicity. Further provided are a composition containing the aforementioned compound, and the use thereof in the delivery of a therapeutic or prophylactic agent.

Abstract: Provided are a GalNAc compound containing a ribose ring or its derivative structure and an oligonucleotide conjugate thereof. The oligonucleotide conjugate can achieve efficient liver-targeted delivery and improve the efficacy of the drug.

Abstract: Provided in the present invention are long-acting low-toxicity novel cationic lipid compounds, which are compounds shown as formula (I), or N-oxides, solvates, pharmaceutically acceptable salts or stereoisomers thereof. Further provided are a composition comprising the compounds and the use thereof for the delivery of therapeutic or prophylactic agents.

Abstract: The present invention provides a cationic lipid compound with high efficiency, low toxicity and stable expression, which is a compound of formula (I) or an N-oxide, a solvate, a pharmaceutically acceptable salt or a stereoisomer thereof Further provided are a composition comprising the described compound and a use thereof in delivering a therapeutic or prophylactic agent.

Abstract: A compound of Formula (I) or an N-oxide, a solvate, a pharmaceutically acceptable salt or a stereoisomer thereof is an ionizable cationic lipid compound.

Abstract: The present disclosure relates to siRNAs that target and regulate PCSK9 gene expression and use thereof. Experimental results show that some alternately modified and specific template-modified oligonucleotide sequences can significantly inhibit PCSK9 expression and can be used to develop drugs to treat PCSK9-related diseases.

Abstract: Latency, response times, and efficiency improvements for data querying are provided herein, particularly in the context of querying large database systems and data tables from disparate data sources. There are provided systems and methods for automatic query and data retrieval optimization through procedural generation of data tables from query patterns. A service provider may utilize different computing services for query processing and data retrieval for different applications and services used by internal and/or external users. Instead of querying large database systems and numerous data tables, pre-aggregated data tables may instead be used and searched by procedurally generating such tables based on precomputation rules and query patterns. Once patterns have been identified in queries, corresponding data may be aggregated from data sources in a pre-aggregated data table. Query optimization rules may then be used to have these data tables queried in place of their original sources.

Abstract: Latency, response times, and efficiency improvements for data querying are provided herein, particularly in the context of querying large database systems and data tables from disparate data sources. There are provided systems and methods for automatic query and data retrieval optimization through procedural generation of data tables from query patterns. A service provider may utilize different computing services for query processing and data retrieval for different applications and services used by internal and/or external users. Instead of querying large database systems and numerous data tables, pre-aggregated data tables may instead be used and searched by procedurally generating such tables based on precomputation rules and query patterns. Once patterns have been identified in queries, corresponding data may be aggregated from data sources in a pre-aggregated data table. Query optimization rules may then be used to have these data tables queried in place of their original sources.

Abstract: The present disclosure provides a C6?-substituted locked nucleic acid-modified cap analog and a use thereof, wherein the cap analog improves the stability of mRNA and/or the translation efficiency of mRNA.

Abstract: A reconfigurable dataflow unit (RDU) includes an intra-RDU network, an array of configurable units connected by an array level network and function interfaces. The RDU also includes interface circuits coupled between the intra-RDU network and external interconnects. An interface circuit receives a packet from the external interconnect and extracts a target RDU identifier and compares the target RDU identifier to the value of the identity register. It also communicates over the intra-RDU network to a function interface based on information in the first packet in response to the target RDU identifier being equal to the identity register. The interface circuit retrieves another interface circuit identifier for the target RDU identifier from the pass-through table and, in response to the target RDU identifier not being equal to the identity register, sends the target RDU identifier and other information to the other interface circuit over the intra-RDU network.

Abstract: A reconfigurable dataflow unit (RDU) includes an intra-RDU network, an array of configurable units connected by an array level network and function interfaces. The RDU also includes interface circuits coupled between the intra-RDU network and external interconnects. An interface circuit receives a packet from the external interconnect and extracts a target RDU identifier and compares the target RDU identifier to the value of the identity register. It also communicates over the intra-RDU network to a function interface based on information in the first packet in response to the target RDU identifier being equal to the identity register. The interface circuit retrieves another interface circuit identifier for the target RDU identifier from the pass-through table and, in response to the target RDU identifier not being equal to the identity register, sends the target RDU identifier and other information to the other interface circuit over the intra-RDU network.

Abstract: Provided in the present disclosure is a compound of formula (I), or an N-oxide, solvate, pharmaceutically acceptable salt or stereoisomer thereof, which is an extrahepatic targeted cationic lipid compound with high efficiency and low toxicity. Further provided are a composition containing the aforementioned compound, and the use thereof in the delivery of a therapeutic or prophylactic agent.

Abstract: Provided in the present disclosure are a compound of formula (I), or an N-oxide, solvate, pharmaceutically acceptable salt or stereoisomer thereof. Further provided are a composition containing the aforementioned compound, and the use thereof in the delivery of a therapeutic agent or prophylactic agent.

Abstract: Provided in the present disclosure are a compound of formula (I), or an N-oxide, solvate, pharmaceutically acceptable salt or stereoisomer thereof. Further provided are a composition containing the aforementioned compound, and the use thereof in the delivery of a therapeutic agent or prophylactic agent.

Abstract: Provided in the present disclosure are a compound of formula (I), or an N-oxide, solvate, pharmaceutically acceptable salt or stereoisomer thereof. Further provided are a composition containing the aforementioned compound, and the use thereof in the delivery of a therapeutic agent or prophylactic agent.

Abstract: The technology disclosed relates to runtime execution of functions across reconfigurable processor. In particular, the technology disclosed relates to a runtime logic that is configured to execute a first set of functions in a plurality of functions and/or data therefor on a first reconfigurable processor, and a second set of functions in the plurality of functions and/or data therefor on additional reconfigurable processors. Functions in the second set of functions and/or the data therefor are transmitted to the additional reconfigurable processors using one or more of a first reconfigurable processor-to-additional reconfigurable processors buffers, and results of executing the functions and/or the data therefor on the additional reconfigurable processors are transmitted to the first reconfigurable processor using one or more of additional reconfigurable processors-to-first reconfigurable processor buffers.

Abstract: The technology disclosed relates to inter-node execution of configuration files on reconfigurable processors using network interface controller (NIC) buffers. In particular, the technology disclosed relates to a runtime logic that is configured to execute configuration files that define applications and application data for applications using a first reconfigurable processor connected to a first host, and a second reconfigurable processor connected to a second host. The first reconfigurable processor is configured to push input data for the applications in a first plurality of buffers. The first host is configured to cause a first network interface controller (NIC) to stream the input data to a second plurality of buffers from the first plurality of buffers. The second host is configured to cause a second NIC to stream the input data to the second reconfigurable processor from the second plurality of buffers.

Abstract: A reconfigurable dataflow unit (RDU) includes an intra-RDU network, an array of configurable units connected by an array level network and function interfaces. The RDU also includes interface circuits coupled between the intra-RDU network and external interconnects. An interface circuit receives a packet from the external interconnect and extracts a target RDU identifier and compares the target RDU identifier to the value of the identity register. It also communicates over the intra-RDU network to a function interface based on information in the first packet in response to the target RDU identifier being equal to the identity register. The interface circuit retrieves another interface circuit identifier for the target RDU identifier from the pass-through table and, in response to the target RDU identifier not being equal to the identity register, sends the target RDU identifier and other information to the other interface circuit over the intra-RDU network.