Abstract: The present disclosure provides a class of Pyridopyrimidine compounds having a structure shown in Formula (I) or their pharmaceutically acceptable salts, or stereoisomers or prodrug molecules and applications thereof. The compounds in the present disclosure can efficiently and selectively degrade AKT3 protein in cells without affecting AKT1/2, thereby significantly inhibiting tumor cell proliferation mediated by high expression of AKT3 protein. It can be used to prepare therapeutic drugs for cancer and other diseases related to abnormal expression of AKT3 protein.

Abstract: A macrocyclic TLR7 agonist, a preparation method therefor, a pharmaceutical composition and use thereof. The macrocyclic TLR7 agonist disclosed is as represented by formula I, has good TLR7 agonistic activity, and can be used for treating or preventing tumors or infections caused by viruses.

Abstract: A method and apparatus for indicating a TCI state. The method includes: determining, based on a structure of second DCI signaling used to deactivate a SPS PDSCH resource, first DCI signaling used to indicate a currently activated TCI state such that the first DCI signaling does not schedule a PDSCH; and sending the first DCI signaling. A code point of a TCI field and/or of a HARQ process number field of the first DCI signaling is associated with the currently activated TCI state. A code point of a MCS field of the first DCI signaling is all 1. If a PDSCH FDRA type is Type 1, a code point of an FDRA field of the first DCI signaling is all 1, otherwise the code point of the FDRA field of the first DCI signaling is all 0.

Abstract: Embodiments of the present disclosure provide a datum selection method for minimizing hole position errors in group hole machining of large components, comprising: 1) determining a type of a computer numerical control (CNC) machine tool and establishing a topological structure of the CNC machine tool; 2) establishing a theoretical postural model of a tool center point during a motion; 3) establishing a hole position error model; 4) establishing an average error model of hole positions in group hole machining; and 5) obtaining a machining datum for group holes of corresponding components. For the skeleton and skinned group hole machining of aircraft components, different principles of datum selection are provided respectively, which can effectively improve the positional accuracy of the skeleton or skinned group hole machining, at the same time provides a more scientific and reasonable approach for the datum selection in group hole machining of large components.

Abstract: Uplink channel measurement method and apparatus for multi-TRP scene, storage medium, terminal, and base station are provided.

Abstract: Aperiodic ZP CSI-RS resource set determination and configuration methods and devices, a storage medium, a user equipment, and a network end. The determination method comprises: receiving a PDCCH, and the PDCCH scheduling K time slots for transmitting a PDSCH; extracting from the PDCCH a preset number of bits of indication information of an aperiodic ZP CSI-RS resource set; extracting ?log2 J? bits from the indication information, and determining a selected aperiodic ZP CSI-RS resource set according to an extraction result; and determining, according to a comparison result between the number of bits of the indication information and ?log2 J?, the position of a ZP CSI-RS resource indicated by the selected aperiodic ZP CSI-RS resource set in the K time slots. The solution of the invention enables UE to accurately determine a selected aperiodic ZP CSI-RS resource, thereby improving the accuracy of decoding.

Abstract: A method and an apparatus for determining a PDSCH reception beam, a storage medium, and a terminal are provided. The method includes: receiving one or more PDCCHs and determining a to-be-received PDSCH, wherein the to-be-received PDSCH is repeatedly scheduled by the one or more PDCCHs; determining a duration between a last symbol of the one or more PDCCHs which schedule the to-be-received PDSCH and a first symbol of the to-be-received PDSCH; using a first reception beam to receive the to-be-received PDSCH based on the duration being shorter than a preset duration; and using a second reception beam to receive the to-be-received PDSCH based on the duration being longer than or equal to the preset duration, wherein the first reception beam and the second reception beam are the same or different.

Abstract: An uplink data transmission method, a user equipment, and a readable storage medium are provided. The method includes: receiving DCI, wherein the DCI includes a sounding reference signal resource indication field and a precoding information field, the sounding reference signal resource indication field includes indication information of two or more transmission beams corresponding to to-be-transmitted uplink data, and the precoding information field includes transmission precoding matrix indication information corresponding to each of the two or more transmission beams; determining a transmission precoding matrix corresponding to each transmission beam based on the transmission precoding matrix indication information corresponding to the transmission beam; and transmitting uplink data based on the transmission precoding matrix corresponding to each transmission beam.

Abstract: A method and apparatus for determining CPU occupancy time for a multiple PDCCH repeated transmission scenario, a storage medium, and a terminal are provided. The method includes: in response to receiving a PDCCH currently, determining whether a time domain position of a last PDCCH can be determined based on the currently received PDCCH and configuration information for a plurality of PDCCHs, wherein the currently received PDCCH and the last PDCCH belong to the plurality of PDCCHs, and the configuration information for the plurality of PDCCHs is used to configure candidate resource positions of each of the plurality of PDCCHs; and based on that the time domain position of the last PDCCH can be determined, determining the CPU occupancy time based on the time domain position of the last PDCCH and a time domain position of a PUSCH scheduled by the currently received PDCCH.

Abstract: An uplink data transmission method, a user equipment and a readable storage medium are provided. The method includes: receiving uplink scheduling information, wherein the uplink scheduling information comprises indication information of a Transmitted Precoding Matrix Indicator (TPMI) corresponding to each subband used for transmitting the uplink data, and the indication information of the TPMI corresponding to each subband corresponds to a same Rank Indicator (RI) information; determining a precoding matrix corresponding to each subband based on the indication information of the TPMI corresponding to each subband, respectively; and precoding the uplink data to be transmitted on each subband based on the precoding matrix corresponding to each subband, respectively, and transmitting the uplink data.

Abstract: The present disclosure relates to a port configuration method and device, the method comprises: receiving antenna port configuration parameters, the antenna port configuration parameters being adapted to information on transmission capability of a terminal; and determining an association relationship set between port selection parameters and demodulation reference signal DMRS port identifiers according to the antenna port configuration parameters. The present disclosure determines the association relationship set adapted to the transmission capability of the terminal by using the antenna port configuration parameters sent by a base station, and obtains the DMRS port in accordance with the determined antenna port data so as to configure the port, thereby avoiding blind configuration on the port of the terminal, improving efficiency of the terminal configuration, and reducing signaling overhead of the configuration.

Abstract: The present invention provides a preparation method for a natural product Trabectedin. Specifically, the present invention provides a preparation method for Et-743. In the method, tyrosine is used as an initial substrate, and after 26 steps of reaction, the Et-743 is synthesized. Raw materials and agents used in the synthetic route can all easily be obtained, reaction conditions are relatively mild, and preparation in large scale can be implemented.

Abstract: A wake-up signal resource determining method and apparatus, a wake-up signal resource configuration method and apparatus, a terminal, and a base station. The resource determining method comprises: receiving resource configuration information sent by a network; and determining, according to the resource configuration information, a frequency domain resource and/or a time domain resource configured for awake-up signal. According to the technical solutions provided by embodiments of the present invention, resources for wake-up signals can be flexibly configured, and resource conflict between different wake-up signals is avoided.

Abstract: A method and device for determining a time-frequency pattern of a downlink positioning reference signal, a storage medium and a base station, the method including: determining a number of subcarriers M occupied by a time-frequency pattern of a positioning reference signal on each symbol according to a preset frequency domain multiplexed factor; generating, for multiple time slots scheduled by a user equipment, initial time-frequency patterns in a resource block where each time slot is located according to the number of subcarriers M, the initial time-frequency patterns occupying all symbols in the resource block, and occupying M subcarriers on each symbol; and filtering M initial time-frequency patterns in each resource block according to the attributes of the symbol in each resource block, so as to determine valid time-frequency patterns in each resource block. Therefore, a time-frequency pattern of a downlink positioning reference signal in a NR system may be determined.

Abstract: Provided by the present application are a cell necrosis inhibitor, a preparation method therefor and a use thereof; in particular, provided by the present application is an inhibitor of cell necrosis and/or human receptor-interacting protein 1 kinase (RIP1). The inhibitor has a structure as shown in the following formula I. The compound and a composition comprising same may be used to prevent and/or treat diseases involving cell death and/or inflammation.

Abstract: Aperiodic ZP CSI-RS resource set determination and configuration methods and devices, a storage medium, a user equipment, and a network end. The determination method comprises: receiving a PDCCH, and the PDCCH scheduling K time slots for transmitting a PDSCH; extracting from the PDCCH a preset number of bits of indication information of an aperiodic ZP CSI-RS resource set; extracting ?log2 J? bits from the indication information, and determining a selected aperiodic ZP CSI-RS resource set according to an extraction result; and determining, according to a comparison result between the number of bits of the indication information and ?log2 J?, the position of a ZP CSI-RS resource indicated by the selected aperiodic ZP CSI-RS resource set in the K time slots. The solution of the invention enables UE to accurately determine a selected aperiodic ZP CSI-RS resource, thereby improving the accuracy of decoding.

Abstract: The present invention provides a preparation method for a natural product Trabectedin. Specifically, the present invention provides a preparation method for Et-743. In the method, tyrosine is used as an initial substrate, and after 26 steps of reaction, the Et-743 is synthesized. Raw materials and agents used in the synthetic route can all easily be obtained, reaction conditions are relatively mild, and preparation in large scale can be implemented.

Abstract: The present disclosure provides a blade inspection device, a method and a printing modification device, and belongs to the technical field of screen printing. The blade inspection device includes a telescopic component, a driving component and a parameter obtaining module. The driving component is configured to drive the telescopic component to move in a direction parallel to the line where the blade is located. The parameter obtaining module is configured to obtain a first parameter to inspect the blade according to the first parameter. The first parameter is related to a displacement of the first end of the telescopic component in a direction perpendicular to the line where the blade is located.

Abstract: Provided are a heterocyclic carboxylic acid amide ligand and applications thereof in a copper catalyzed coupling reaction. Specifically, provided are uses of a compound represented by formula (I), definitions of radical groups being described in the specifications. The compound represented by formula (I) can be used as the ligand in the copper catalyzed coupling reaction of the aryl halogeno substitute, and is used or catalyzing the coupling reaction for forming the aryl halogeno substitute having C—N, C—O, C—S and other bonds.

Abstract: The present invention provides an EGFR kinase inhibitor and a preparation method and use thereof. Specifically, the present invention provides a compound as shown in formula (I), the definition of each group therein being as described in the description. Said compound is an efficient EGFR inhibitor.