Abstract: The present invention relates to a gonadotropin-releasing hormone antagonist, which has an antagonistic activity against gonadotropin-releasing hormone and can be used for the prevention or treatment of a sex hormone-dependent disease, such as benign prostatic hypertrophy, hysteromyoma, endometriosis, metrofibroma, precocious puberty, amenorrhea, premenstrual syndrome, or dysmenorrhea, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof, and a pharmaceutical composition comprising the same.

Abstract: A frozen stuffed fish ball with low soup loss and the method of preparing the same. By combining hydrocolloid and oil pre-emulsification technology, the problems of taste of powder, soup loss of fish balls after freeze-thaw cooking and the taste of frozen stuffed fish balls after freeze-thaw cooking are solved. The use of konjac gum and carrageenan or curdlan respectively, combined with oil pre-emulsification technology, also effectively improves the texture and brightness of the outer skin of fish balls. Compared with a single addition of conventional technology, the hardness, elasticity and brightness are increased, solving loosen structure, brightness and other problems due to freeze-thaw cycle. Further, it may be used in the fish ball processing line for preparing fish ball with fillings and other stuffed surimi products.

Abstract: A modified T cell comprising a functional exogenous receptor is provided. The functional exogenous receptor comprises: (a) an extracellular ligand binding domain, (b) a transmembrane domain, and (c) an intracellular signaling domain (ISD) comprising a chimeric signaling domain (CMSD), wherein the CMSD comprises a plurality of Immune-receptor Tyrosine-based Activation Motifs (ITAMs) optionally connected by one or more linkers. Further provided are vectors, methods of producing, pharmaceutical compositions, kits, and methods of treatment thereof.

Abstract: The present invention relates to a class of compounds that serve as VMAT2 inhibitors, and relates in particular to a compound represented by formula (I), or a stereoisomer or pharmaceutically acceptable salt thereof, and a preparation method therefor, as well as the use thereof in the preparation of a medicament for treating diseases related to VMAT2.

Abstract: A modified T cell comprises: i) an exogenous Negative Regulatory Factor (Nef) protein; and ii) a functional exogenous receptor comprising: (a) an extracellular ligand binding domain, (b) a transmembrane domain, and (c) an intracellular signaling domain (ISD) comprising a chimeric signaling domain (CMSD), wherein the CMSD comprises one or a plurality of Immune-receptor Tyrosine-based Activation Motifs (ITAMs), wherein the plurality of CMSD ITAMs are optionally connected by one or more linkers. Provided are also Nef proteins (e.g., non-naturally occurring Nef), and modified T cells comprising such Nef proteins. Provided are methods of making and uses thereof.

Abstract: A modified T cell comprising a functional exogenous receptor is provided. The functional exogenous receptor comprises: (a) an extracellular ligand binding domain, (b) a transmembrane domain, and (c) an intracellular signaling domain (ISD) comprising a chimeric signaling domain (CMSD), wherein the CMSD comprises a plurality of Immune-receptor Tyrosine-based Activation Motifs (ITAMs) optionally connected by one or more linkers. Further provided are vectors, methods of producing, pharmaceutical compositions, kits, and methods of treatment thereof.

Abstract: Provided are a method of producing a modified T cell comprising introducing into a precursor T cell a first nucleic acid encoding a Nef protein, wherein the Nef protein upon expression results in down-modulation of the endogenous T cell receptor (TCR) in the modified T cell, wherein the modified T cell furthermore expresses a functional exogenous receptor, such as an engineered TCR (e.g., chimeric TCR), T cell antigen coupler (TAC), TAC-like chimeric receptor, or a chimeric antigen receptor (CAR), the modified cell obtained by the method and the pharmaceutical composition comprising the modified T cell. Also provided is a non-naturally occurring Nef protein comprising one or more mutations.

Abstract: A direct reduction process for the production of ferrochrome from chromite ore or concentrate is disclosed. According to the present invention, calcium chloride (CaCl2) is added as a catalyst to accelerate the solid reduction and enhance the particle growth of the metallic phase (i.e. ferrochrome) during reduction. The reduction of chromite ore or concentrate takes place at much lower temperatures (e.g. 1200 to 1400° C.) compared to the conventional smelting technologies, and the ferrochrome particles formed are segregated from the unwanted residual gangue and spinel particles, facilitating their subsequent physical separation.

Abstract: A direct reduction process for the production of ferrochrome from chromite ore or concentrate is disclosed. According to the present invention, calcium chloride (CaCl2) is added as a catalyst to accelerate the solid reduction and enhance the particle growth of the metallic phase (i.e. ferrochrome) during reduction. The reduction of chromite ore or concentrate takes place at much lower temperatures (e.g. 1200 to 1400° C.) compared to the conventional smelting technologies, and the ferrochrome particles formed are segregated from the unwanted residual gangue and spinel particles, facilitating their subsequent physical separation.

Abstract: A scanning alignment apparatus and scanning methods thereof are disclosed. The scanning alignment apparatus is used to scan a substrate and includes a transflective lens unit, an imaging element unit, an alignment lens unit and an illumination lens unit. The alignment lens unit includes a plurality of sub-alignment lens units, and the imaging element unit includes a plurality of imaging elements. Each of the sub-alignment lens units corresponds to a respective one of the imaging elements. The scanning alignment apparatus and scanning methods provided in the present invention can achieve higher scanning efficiency and thus enhanced productivity and product throughput.

Abstract: A pre-alignment measurement device includes, disposed in a direction of propagation of light, a laser, a first cylindrical lens, a first imaging lens, an illumination diaphragm, a second imaging lens, a second cylindrical lens and a CCD detector. The laser, an object under measurement and the CCD detector are arranged at respective apexes of a triangle formed by the measurement device for pre-alignment. A light beam is emanated by the laser and is transformed into a line beam. The line beam is reflected by the object under measurement and then passes through the second cylindrical lens to form a CCD image which has different horizontal and vertical magnifications, allowing horizontal and vertical resolutions to be matched with horizontal and vertical measuring ranges, respectively. The CCD image contains information of a position and a height of a step defined by the object under measurement and the wafer stage.

Abstract: A pre-alignment measurement device includes, disposed in a direction of propagation of light, a laser, a first cylindrical lens, a first imaging lens, an illumination diaphragm, a second imaging lens, a second cylindrical lens and a CCD detector. The laser, an object under measurement and the CCD detector are arranged at respective apexes of a triangle formed by the measurement device for pre-alignment. A light beam is emanated by the laser and is transformed into a line beam. The line beam is reflected by the object under measurement and then passes through the second cylindrical lens to form a CCD image which has different horizontal and vertical magnifications, allowing horizontal and vertical resolutions to be matched with horizontal and vertical measuring ranges, respectively. The CCD image contains information of a position and a height of a step defined by the object under measurement and the wafer stage.

Abstract: Embodiments of the present disclosure provide a video quality detection method, including collecting video frame data, wherein the video frame data comes from at least two media products; choosing, according to a preset video detection condition, to perform active video quality detection or passive video quality detection on the video frame data; performing the active video quality detection on the video frame data according to a video processing algorithm of the active video quality detection; or performing the passive video quality detection on the video frame data according to a video processing algorithm of the passive video quality detection; and acquiring abnormal video frame data, and sending a quality detection report of the abnormal video frame data to a video frame abnormality processing module. The embodiments of the present disclosure further provide a video quality detection apparatus.

Abstract: A method, system, and apparatus for renewing a program are disclosed. The method includes: obtaining programs associated with a set renewed program according to the renewed program; using one or more of the obtained associated programs as successive programs to the renewed program; and renewing the successive programs automatically. The present invention brings the following benefits: Programs in multiple series or programs associated with a program can be renewed automatically, which overcomes the problems in the prior art, namely, separate renewal of every episode of a program series or separate renewal of programs associated with a renewed program, complicated user operations, and poor user experiences.

Abstract: A method for watching a missed television (TV) program and a user terminal are provided. The method includes the following steps. Electronic program guide (EPG) information distributed by a headend is received, and a local table of missed programs and current time are obtained. It is determined that a missed program exits when the user terminal is in a non-working status according to the local table of missed programs and the current time. Information of the missed program in the local table of missed programs is updated according to the EPG information. It is detected whether the missed program is played currently, and if yes, a service of watching a missed program is implemented. By using the method for making up for watching the missed TV program and the user terminal, when the missed program of the user is played in a system, the user is reminded in time of watching the missed program, and a trouble that the user searches the missed program through the EPG is avoided.

Abstract: A method, terminal, and system for playing programs are disclosed. The method includes: creating virtual channels corresponding to keywords in a keyword list according to the keywords, and using the virtual channels to form a virtual channel list; identifying programs inclusive of the keywords among received programs; using the programs inclusive of the keywords to generate a playlist of the virtual channels corresponding to the keywords according to a preset playlist generation rule; and playing the programs in the playlist. Through the present disclosure, the same type of BTV programs that match a keyword on different channels are scheduled together, the required operations of pressing keys are reduced, and the user experience is improved.

Abstract: A method for watching a missed television (TV) program and a user terminal are provided. The method includes the following steps. Electronic program guide (EPG) information distributed by a headend is received, and a local table of missed programs and current time are obtained. It is determined that a missed program exits when the user terminal is in a non-working status according to the local table of missed programs and the current time. Information of the missed program in the local table of missed programs is updated according to the EPG information. It is detected whether the missed program is played currently, and if yes, a service of watching a missed program is implemented. By using the method for making up for watching the missed TV program and the user terminal, when the missed program of the user is played in a system, the user is reminded in time of watching the missed program, and a trouble that the user searches the missed program through the EPG is avoided.

Abstract: A method, terminal, and system for playing programs are disclosed. The method includes: creating virtual channels corresponding to keywords in a keyword list according to the keywords, and using the virtual channels to form a virtual channel list; identifying programs inclusive of the keywords among received programs; using the programs inclusive of the keywords to generate a playlist of the virtual channels corresponding to the keywords according to a preset playlist generation rule; and playing the programs in the playlist. Through the present disclosure, the same type of BTV programs that match a keyword on different channels are scheduled together, the required operations of pressing keys are reduced, and the user experience is improved.

Abstract: A method, system, and apparatus for renewing a program are disclosed. The method includes: obtaining programs associated with a set renewed program according to the renewed program; using one or more of the obtained associated programs as successive programs to the renewed program; and renewing the successive programs automatically. The present invention brings the following benefits: Programs in multiple series or programs associated with a program can be renewed automatically, which overcomes the problems in the prior art, namely, separate renewal of every episode of a program series or separate renewal of programs associated with a renewed program, complicated user operations, and poor user experiences.

Abstract: A method for preventing simultaneous issuance of two multicast flows, comprising a process of ceasing the transmission of a multicast flow upon an internet protocol set-top box (IP STB) being switched on; the ceasing of the multicast flow transmission can be initiated by the IP STB or by communication entities on the network side. The method provided by the present invention prevents simultaneous issuance of two multicast flows and thus eliminates unfavorable consequences of simultaneous issuance of two multicast flows, including picture quality loss and even abnormal restart of an IP STB, therefore the user experiences will be improved and user satisfaction will be distinctively increased.