Patents by Inventor Dawen Niu

Dawen Niu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250154119
    Abstract: A glycosyl donor represented by formula (I) is used for preparing an S-glycoside compound represented by formula (III), an O-glycoside compound represented by formula (V), and a C-glycoside compound represented by formula (V). The glycosyl donor is a raw material in the preparation of O-glycoside, S-glycoside, and C-glycoside compounds by means of a free radical reaction, most of which have a special ? configuration.
    Type: Application
    Filed: January 15, 2025
    Publication date: May 15, 2025
    Inventors: Dawen NIU, Xia ZHANG, Liqiang WAN, Chen ZHANG, Demeng XIE
  • Publication number: 20250059226
    Abstract: A sulfinate glycosyl donor of formula I and a method for preparing same as well as use thereof in preparing a glycoside compound including a thioglycoside compound and a carbon glycoside compound are provided. The sulfinate glycosyl donor has a special sulfinate structure. When the sulfinate glycosyl donor is used as a raw material to prepare the glycoside compound, an additional initiator does not need to be added, such that the production cost is saved, the generation of byproducts is reduced, and the glycoside compound with a purity greater than 98% is obtained. The sulfinate glycosyl donor can be used in the preparation of the glycoside compound such as the thioglycoside compound and the carbon glycoside compound.
    Type: Application
    Filed: November 1, 2024
    Publication date: February 20, 2025
    Inventors: Dawen NIU, Xia ZHANG, Chen ZHANG, Hao ZUO, Hongxin ZENG, Yanjing LI, Jiaxi WANG
  • Publication number: 20250042936
    Abstract: A method for the glycosylation modification of proteins and/or polypeptides uses glycosyl sulfinate as a raw material. The method for glycosylation and modification is applicable not only to proteins and/or peptides containing disulfide bonds, but also to proteins and/or peptides containing sulfhydryl groups. The method is even applicable to proteins and/or peptides containing both disulfide bonds and sulfhydryl groups.
    Type: Application
    Filed: October 15, 2024
    Publication date: February 6, 2025
    Inventors: Dawen NIU, Xia ZHANG, Chen ZHANG, Hao ZUO, Hongxin ZENG, Yanjing LI, Jiaxi WANG, Haiyan REN
  • Publication number: 20250042930
    Abstract: In a method for preparing an aryl carbon glycoside compound including a gliflozin drug, a sulfinate glycosyl donor represented by formula W is used as a raw material to prepare the aryl carbon glycoside compound including the gliflozin drug. The method does not need to use an additional initiator.
    Type: Application
    Filed: October 11, 2024
    Publication date: February 6, 2025
    Inventors: Dawen NIU, Xia ZHANG, Chen ZHANG, Hao ZUO, Hongxin ZENG, Yanjing LI, Jiaxi WANG
  • Patent number: 12202812
    Abstract: A glycosyl donor represented by formula (I) is used for preparing an S-glycoside compound represented by formula (III), an O-glycoside compound represented by formula (V), and a C-glycoside compound represented by formula (V). The glycosyl donor is a raw material in the preparation of O-glycoside, S-glycoside, and C-glycoside compounds by means of a free radical reaction, most of which have a special ? configuration.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: January 21, 2025
    Assignee: SICHUAN UNIVERSITY
    Inventors: Dawen Niu, Xia Zhang, Liqiang Wan, Chen Zhang, Demeng Xie
  • Publication number: 20220127239
    Abstract: A glycosyl donor represented by formula (I) is used for preparing an S-glycoside compound represented by formula (III), an O-glycoside compound represented by formula (V), and a C-glycoside compound represented by formula (V). The glycosyl donor is a raw material in the preparation of O-glycoside, S-glycoside, and C-glycoside compounds by means of a free radical reaction, most of which have a special ? configuration.
    Type: Application
    Filed: July 21, 2020
    Publication date: April 28, 2022
    Inventors: Dawen NIU, Xia ZHANG, Liqiang WAN, Chen ZHANG, Demeng XIE
  • Patent number: 9505789
    Abstract: The invention provides methods for cyclizing poly-yne compounds under mild conditions to provide cyclic compounds.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: November 29, 2016
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Thomas R. Hoye, Beeraiah Baire, Dawen Niu, Patrick H. Willoughby, Brian P. Woods