Patents by Inventor Dawn Bowdish
Dawn Bowdish has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11577248Abstract: A biosensor detector device is disclosed suitable for use in measuring membrane fluidity or membrane permeability. The biosensor detector device is formed of a solid substrate having a lipid bilayer compatible surface, a multi-lamellar lipid membrane structure derived from a biological cell and localized on the lipid bilayer compatible surface, an aqueous layer interposed between each lipid bilayer of the multi-lamellar lipid membrane structure. The biological membrane is derived from human red blood cells and localized on the lipid bilayer compatible surface. An electrode forming all or part of the lipid bilayer compatible surface may be used to detect disruptions in the multi-lamellar lipid membrane structure and hemolytic activity in a test sample.Type: GrantFiled: December 21, 2018Date of Patent: February 14, 2023Assignee: McMaster UniversityInventors: Maikel Rheinstadter, Sebastian Himbert, Richard Alsop, Jose Moran-Mirabal, Sokunthearath Saem, Dawn Bowdish
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Publication number: 20190195867Abstract: A biosensor detector device is disclosed suitable for use in measuring membrane fluidity or membrane permeability. The biosensor detector device is formed of a solid substrate having a lipid bilayer compatible surface, a multi-lamellar lipid membrane structure derived from a biological cell and localized on the lipid bilayer compatible surface, an aqueous layer interposed between each lipid bilayer of the multi-lamellar lipid membrane structure. The biological membrane is derived from human red blood cells and localized on the lipid bilayer compatible surface. An electrode forming all or part of the lipid bilayer compatible surface may be used to detect disruptions in the multi-lamellar lipid membrane structure and hemolytic activity in a test sample.Type: ApplicationFiled: December 21, 2018Publication date: June 27, 2019Inventors: Maikel Rheinstadter, Sebastian Himbert, Richard Alsop, Jose Moran-Mirabal, Sokunthearath Saem, Dawn Bowdish
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Patent number: 7687454Abstract: A method of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described. A method of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response. The method includes contacting cells with LPS, LTA, CpG DNA and/or intact microbe or microbial components in the presence or absence of a cationic peptide; detecting a pattern of polynucleotide expression for the cells in the presence and absence of the peptide, wherein the pattern in the presence of the peptide represents inhibition of an inflammatory or septic response. Also included are compounds and agents identified by the methods of the invention. In another aspect, the invention provides methods and compounds for enhancing innate immunity in a subject.Type: GrantFiled: September 12, 2003Date of Patent: March 30, 2010Assignee: The University of British ColumbiaInventors: Robert E. W. Hancock, B. Brett Finlay, Monisha Gough Scott, Dawn Bowdish, Carrie Melissa Rosenberger, Jon-Paul Steven Powers
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Patent number: 7507787Abstract: A method of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described. A method of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response. The method includes contacting cells with LPS, LTA, CpG DNA and/or intact microbe or microbial components in the presence or absence of a cationic peptide; detecting a pattern of polynucleotide expression for the cells in the presence and absence of the peptide, wherein the pattern in the presence of the peptide represents inhibition of an inflammatory or septic response. Also included are compounds and agents identified by the methods of the invention. In another aspect, the invention provides methods and compounds for enhancing innate immunity in a subject.Type: GrantFiled: December 2, 2002Date of Patent: March 24, 2009Assignee: The University of British ColumbiaInventors: Robert E. W. Hancock, B. Brett Finlay, Monisha Gough Scott, Dawn Bowdish, Carrie Melissa Rosenberger, Jon-Paul Steven Powers
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Publication number: 20070190533Abstract: The present invention provides a method of identifying agents that enhance innate immunity in a subject. The invention further provides a method of selectively supresses sepsis by suppressing expression of a proinflammatory gene while maintaining expression of an anti-inflammatory gene. Also provided are methods of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described, methods of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response, and compounds and agents identified by the methods of the invention.Type: ApplicationFiled: September 29, 2005Publication date: August 16, 2007Inventors: Robert Hancock, B. Finlay, Monisha Gough Scott, Dawn Bowdish, Carrie Rosenberger, Jon-Paul Powers
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Publication number: 20070134261Abstract: The present invention provides a method of identifying agents that enhance innate immunity in a subject. The invention further provides a method of selectively supressing sepsis by suppressing expression of a proinflammatory gene while maintaining expression of an anti-inflammatory gene. Also provided are methods of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described, methods of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response, and compounds and agents identified by the methods of the invention.Type: ApplicationFiled: April 7, 2006Publication date: June 14, 2007Inventors: Robert Hancock, B. Finlay, Monisha Gough Scott, Dawn Bowdish, Carrie Rosenberger, Jon-Paul Steven Powers, Jie Yu, Neeloffer Mookherjee
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Publication number: 20040180038Abstract: A method of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described. A method of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response. The method includes contacting cells with LPS, LTA, CpG DNA and/or intact microbe or microbial components in the presence or absence of a cationic peptide; detecting a pattern of polynucleotide expression for the cells in the presence and absence of the peptide, wherein the pattern in the presence of the peptide represents inhibition of an inflammatory or septic response. Also included are compounds and agents identified by the methods of the invention. In another aspect, the invention provides methods and compounds for enhancing innate immunity in a subject.Type: ApplicationFiled: September 12, 2003Publication date: September 16, 2004Inventors: Robert E. W. Hancock, B. Brett Finlay, Monisha Gough Scott, Dawn Bowdish, Carrie Melissa Rosenberger, Jon-Paul Steven Powers
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Publication number: 20040001803Abstract: A method of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described. A method of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response. The method includes contacting cells with LPS, LTA, CpG DNA and/or intact microbe or microbial components in the presence or absence of a cationic peptide; detecting a pattern of polynucleotide expression for the cells in the presence and absence of the peptide, wherein the pattern in the presence of the peptide represents inhibition of an inflammatory or septic response. Also included are compounds and agents identified by the methods of the invention. In another aspect, the invention provides methods and compounds for enhancing innate immunity in a subject.Type: ApplicationFiled: December 2, 2002Publication date: January 1, 2004Inventors: Robert E.W. Hancock, B. Brett Finlay, Monisha Gough Scott, Dawn Bowdish, Carrie Melissa Rosenberger, Jon-Paul Steven Powers