Patents by Inventor Dawn Moore
Dawn Moore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240148868Abstract: Provided herein are chimeric receptors, engineered cells and pharmaceutical compositions for enhancement of long-term clearance of protein aggregates in the central nervous system via phagocytosis or engulfment. Further provided herein are methods of treatment of subjects suffering from, or diagnosed with, a neurodegenerative disease by administering these receptors, modified cells, and/or pharmaceutical compositions. Administration of one or more, or a plurality of these modified cells, to a subject may provide treatment of a neurodegenerative disease such as Alzheimer's Disease (AD) or Parkinson's Disease (PD). Advantageously, the modified cells, pharmaceutical compositions, and methods of the present disclosure meet existing needs in the art by providing clearance of accumulations of protein aggregates in brain tissue in PD and AD pathologies.Type: ApplicationFiled: March 17, 2022Publication date: May 9, 2024Applicant: University of Florida Research Foundation, IncorporatedInventors: Todd Eliot Golde, Marshall S. Goodwin, Brenda Dawn Moore, Thomas B. Ladd, Yong Ran, Yona Levites, Pedro Cruz
-
Patent number: 11629183Abstract: Disclosed herein are monoclonal antibodies targeting specific tau epitopes, particularly, microtubule binding domain region 2 or region 4. Also disclosed herein are antibodies or antigen binding fragments thereof that specifically recognize a tau epitope consisting of the amino acid sequence of SEQ ID NO: 9 or 11. Also disclosed herein are methods of detecting tau protein in a subject, comprising performing an assay using the antibodies or antigen binding fragments thereof on the subject or on a biological sample obtained from the subject. Assay kits containing the disclosed antibodies are also provided. Further, methods of treating or preventing a tauopathy in a subject by administering to the subject tau antibodies or antigen-binding fragments thereof are provided.Type: GrantFiled: December 28, 2018Date of Patent: April 18, 2023Assignee: University of Florida Research Foundation, Inc.Inventors: Benoit Giasson, Todd Eliot Golde, Cara Louise Croft, Yona Levites, Brenda Dawn Moore
-
Publication number: 20210371514Abstract: Disclosed herein are materials and methods for the treatment of stress-related disorders and cancer. The disclosure provides an antibody, or antigen binding fragment thereof, that specifically binds to a region of corticotropin-releasing hormone (CRH). The disclosure also provides methods of treating a disorder associated with HPA axis activation, such as a stress-related disorder or cancer, comprising administering to a subject in need thereof an antibody or antigen binding fragment thereof described herein in an amount effective to treat the disorder.Type: ApplicationFiled: June 10, 2019Publication date: December 2, 2021Inventors: Todd Eliot Golde, Hunter S. Futch, Brenda Dawn Moore, Benoit Giasson
-
Publication number: 20210070847Abstract: Disclosed herein are monoclonal antibodies targeting specific tau epitopes, particularly, microtubule binding domain region 2 or region 4. Also disclosed herein are antibodies or antigen binding fragments thereof that specifically recognize a tau epitope consisting of the amino acid sequence of SEQ ID NO: 9 or 11. Also disclosed herein are methods of detecting tau protein in a subject, comprising performing an assay using the antibodies or antigen binding fragments thereof on the subject or on a biological sample obtained from the subject. Assay kits containing the disclosed antibodies are also provided. Further, methods of treating or preventing a tauopathy in a subject by administering to the subject tau antibodies or antigen-binding fragments thereof are provided.Type: ApplicationFiled: December 28, 2018Publication date: March 11, 2021Inventors: Benoit Giasson, Todd Eliot Golde, Cara Louise Croft, Yona Levites, Brenda Dawn Moore
-
Publication number: 20150265177Abstract: A method for coupling an ECG monitor with an incompatible ECG lead set includes the steps of providing an ECG adapter including an adapter body having at least one monitor connector adapted for coupling to an input of an ECG monitor and at least one lead set receptacle adapted for coupling to a connector of an ECG lead set incompatible with the input of the ECG monitor, coupling the at least one monitor connector of the adapter body with the input of the ECG monitor and coupling the at least one lead set receptacle of the adapter body with the connector of the ECG lead set to thereby electrically couple the ECG lead set with the ECG monitor.Type: ApplicationFiled: May 29, 2015Publication date: September 24, 2015Inventors: Lee Burnes, Scott Coggins, Dawn Moore, David Selvitelli, Mark Tauer, Kathleen Tremblay
-
Patent number: 9072444Abstract: A method for coupling an ECG monitor with an incompatible ECG lead set includes the steps of providing an ECG adapter including an adapter body having at least one monitor connector adapted for coupling to an input of an ECG monitor and at least one lead set receptacle adapted for coupling to a connector of an ECG lead set incompatible with the input of the ECG monitor, coupling the at least one monitor connector of the adapter body with the input of the ECG monitor and coupling the at least one lead set receptacle of the adapter body with the connector of the ECG lead set to thereby electrically couple the ECG lead set with the ECG monitor.Type: GrantFiled: March 15, 2013Date of Patent: July 7, 2015Assignee: Covidien LPInventors: Lee Burnes, Scott Coggins, Dawn Moore, Dave Selvitelli, Mark Tauer, Kathleen Tremblay
-
Patent number: 8868152Abstract: A sensor array apparatus for monitoring medical signals includes a flexible substrate adapted for positioning relative to the torso of a patient. The flexible substrate includes a central segment defining a central axis and is adapted to generally conform to an area extending along the sternum of a patient. The flexible substrate further includes an upper segment extending traversal across the central segment and adapted to generally conform to the chest area of a patient and a lower segment extending traversal across the central segment and adapted to generally conform to the abdominal area of the patient. The apparatus further includes a medical electrode disposed on at least one of the segments and a connector in electrical communication with the medical electrode and adapted to connect to an electronic monitoring system.Type: GrantFiled: June 25, 2012Date of Patent: October 21, 2014Assignee: Covidien LPInventors: Lee Burnes, Scott R Coggins, Dawn Moore, Mark Tauer
-
Patent number: 8668651Abstract: A method for coupling an ECG monitor with an incompatible ECG lead set includes the steps of providing an ECG adapter including an adapter body having at least one monitor connector adapted for coupling to an input of an ECG monitor and at least one lead set receptacle adapted for coupling to a connector of an ECG lead set incompatible with the input of the ECG monitor, coupling the at least one monitor connector of the adapter body with the input of the ECG monitor and coupling the at least one lead set receptacle of the adapter body with the connector of the ECG lead set to thereby electrically couple the ECG lead set with the ECG monitor.Type: GrantFiled: December 5, 2006Date of Patent: March 11, 2014Assignee: Covidien LPInventors: Lee Burnes, Scott Coggins, Dawn Moore, Dave Selvitelli, Mark Tauer, Kathleen Tremblay
-
Publication number: 20130303927Abstract: A method for coupling an ECG monitor with an incompatible ECG lead set includes the steps of providing an ECG adapter including an adapter body having at least one monitor connector adapted for coupling to an input of an ECG monitor and at least one lead set receptacle adapted for coupling to a connector of an ECG lead set incompatible with the input of the ECG monitor, coupling the at least one monitor connector of the adapter body with the input of the ECG monitor and coupling the at least one lead set receptacle of the adapter body with the connector of the ECG lead set to thereby electrically couple the ECG lead set with the ECG monitor.Type: ApplicationFiled: March 15, 2013Publication date: November 14, 2013Inventors: Lee Burnes, Scott Coggins, Dawn Moore, Dave Selvitelli, Mark Tauer, Kathleen Tremblay
-
Publication number: 20120323104Abstract: A sensor array apparatus for monitoring medical signals includes a flexible substrate adapted for positioning relative to the torso of a patient. The flexible substrate includes a central segment defining a central axis and is adapted to generally conform to an area extending along the sternum of a patient. The flexible substrate further includes an upper segment extending traversal across the central segment and adapted to generally conform to the chest area of a patient and a lower segment extending traversal across the central segment and adapted to generally conform to the abdominal area of the patient. The apparatus further includes a medical electrode disposed on at least one of the segments and a connector in electrical communication with the medical electrode and adapted to connect to an electronic monitoring system.Type: ApplicationFiled: June 25, 2012Publication date: December 20, 2012Applicant: TYCO HEALTHCARE GROUP LPInventors: Lee Burnes, Scott Coggins, Dawn Moore, Mark Tauer
-
Patent number: 8238996Abstract: A sensor array apparatus for monitoring medical signals includes a flexible substrate adapted for positioning relative to the torso of a patient. The flexible substrate includes a central segment defining a central axis and is adapted to generally conform to an area extending along the sternum of a patient. The flexible substrate further includes an upper segment extending traversal across the central segment and adapted to generally conform to the chest area of a patient and a lower segment extending traversal across the central segment and adapted to generally conform to the abdominal area of the patient. The apparatus further includes a medical electrode disposed on at least one of the segments and a connector in electrical communication with the medical electrode and adapted to connect to an electronic monitoring system.Type: GrantFiled: December 5, 2007Date of Patent: August 7, 2012Assignee: Tyco Healthcare Group LPInventors: Lee Burnes, Scott Coggins, Dawn Moore, Mark Tauer
-
Publication number: 20080154110Abstract: A sensor array apparatus for monitoring medical signals includes a flexible substrate adapted for positioning relative to the torso of a patient. The flexible substrate includes a central segment defining a central axis and is adapted to generally conform to an area extending along the sternum of a patient. The flexible substrate further includes an upper segment extending traversal across the central segment and adapted to generally conform to the chest area of a patient and a lower segment extending traversal across the central segment and adapted to generally conform to the abdominal area of the patient. The apparatus further includes a medical electrode disposed on at least one of the segments and a connector in electrical communication with the medical electrode and adapted to connect to an electronic monitoring system.Type: ApplicationFiled: December 5, 2007Publication date: June 26, 2008Inventors: Lee Burnes, Scott Coggins, Dawn Moore, Mark Tauer
-
Publication number: 20080132106Abstract: A method for coupling an ECG monitor with an incompatible ECG lead set includes the steps of providing an ECG adapter including an adapter body having at least one monitor connector adapted for coupling to an input of an ECG monitor and at least one lead set receptacle adapted for coupling to a connector of an ECG lead set incompatible with the input of the ECG monitor, coupling the at least one monitor connector of the adapter body with the input of the ECG monitor and coupling the at least one lead set receptacle of the adapter body with the connector of the ECG lead set to thereby electrically couple the ECG lead set with the ECG monitor.Type: ApplicationFiled: December 5, 2006Publication date: June 5, 2008Inventors: Lee Burnes, Scott Coggins, Dawn Moore, Dave Selvitelli, Mark Tauer, Kathleen Tremblay
-
Patent number: 5949461Abstract: An ink refill bottle for a modified inkjet printhead cassette which has a rear wall opening through which the refill bottle may be inserted comprises a front wall connected to a rear wall by sidewalls to form an ink reservoir chamber, a foam adaptor for drawing ink from the ink chamber when called for by the printhead cassette, and an air inlet metering device for metering air into the ink chamber to replace the ink drawn from the ink chamber and for retaining the remainder of the ink in the ink chamber.Type: GrantFiled: February 18, 1994Date of Patent: September 7, 1999Assignee: Nu-kote Imaging International, Inc.Inventors: Bruce S. Jones, William Allen Putman, Cecelia Dawn Moore