Patents by Inventor Dayananda KASALA

Dayananda KASALA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PH-sensitive and bioreducible polymer-virus complex for cancer treatment
    Patent number: 11970715
    Abstract: Disclosed is a pH-sensitive and bioreducible polymer-virus complex which can destroy tumor cells more effectively by increasing the efficiency of virus transduction. A pH-sensitive and bioreducible polymer contains (i) an escapable portion from immune reactions, (ii) a chargeable portion having one or more amine groups and (iii) a bioreducible portion including one or more disulfide linkages. The and to a pharmaceutical composition containing the polymer-virus complex. Also disclosed are a pharmaceutical composition containing the pH-sensitive and bioreducible polymer-virus complex and methods for treating cancer in a subject, employing the composition.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: April 30, 2024
    Assignee: GENEMEDICINE CO., LTD.
    Inventors: Chae Ok Yun, Dayananda Kasala
  • EFFECTIVE INTRANASAL DELIVERY TO BRAIN
    Publication number: 20220389160
    Abstract: The present invention relates to a technique for effective intranasal delivery to the brain. More specifically, the present invention is used for diagnosing, preventing or treating central nervous system encephalopathy, neurodegenerative diseases or brain tumor by effectively delivering to the brain a pH-responsive and bioreducible PPA polymer, which can be used as a drug carrier, by means of nasal administration.
    Type: Application
    Filed: November 6, 2020
    Publication date: December 8, 2022
    Applicants: Industry-University Cooperation Foundation Hanyang University, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Chae Ok YUN, Soo Hwan LEE, Dayananda KASALA, Robert S LANGER
  • PH-SENSITIVE AND BIOREDUCIBLE POLYMER-VIRUS COMPLEX FOR CANCER TREATMENT
    Publication number: 20220090025
    Abstract: Disclosed is a pH-sensitive and bioreducible polymer-virus complex which can destroy tumor cells more effectively by increasing the efficiency of virus transduction. A pH-sensitive and bioreducible polymer contains (i) an escapable portion from immune reactions, (ii) a chargeable portion having one or more amine groups and (iii) a bioreducible portion including one or more disulfide linkages. The and to a pharmaceutical composition containing the polymer-virus complex. Also disclosed are a pharmaceutical composition containing the pH-sensitive and bioreducible polymer-virus complex and methods for treating cancer in a subject, employing the composition.
    Type: Application
    Filed: September 27, 2021
    Publication date: March 24, 2022
    Applicant: GENEMEDICINE CO., LTD.
    Inventors: Chae Ok YUN, Dayananda KASALA
  • Ph-sensitive and bioreducible polymer-virus complex for cancer treatment
    Patent number: 11174465
    Abstract: The present invention relates to a pH-sensitive and bioreducible polymer-virus complex which can destroy tumor cells more effectively by increasing the efficiency of virus transduction, to a pH-sensitive and bioreducible polymer, and to a pharmaceutical composition containing the polymer-virus complex.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: November 16, 2021
    Assignee: GENEMEDICINE CO., LTD.
    Inventors: Chae Ok Yun, Dayananda Kasala
  • PH-SENSITIVE AND BIOREDUCIBLE POLYMER-VIRUS COMPLEX FOR CANCER TREATMENT
    Publication number: 20170119890
    Abstract: The present invention relates to a pH-sensitive and bioreducible polymer-virus complex which can destroy tumor cells more effectively by increasing the efficiency of virus transduction, to a pH-sensitive and bioreducible polymer, and to a pharmaceutical composition containing the polymer-virus complex.
    Type: Application
    Filed: October 21, 2016
    Publication date: May 4, 2017
    Inventors: Chae Ok YUN, Dayananda KASALA