Abstract: The present invention relates to certain diaryl macrocyclic compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating cancer, pain, neurological diseases, autoimmune diseases, and inflammation.

Abstract: An atomization generator and a special high-pressure atomization generation device for increasing oil and gas field recovery are provided. The special high-pressure atomization generation device for increasing oil and gas field recovery includes an agent pot assembly, a gear pump, a metering pump, an atomization generator and pipelines. The gear pump is connected with the agent pot assembly through an agent pot liquid inlet pipe. The metering pump is arranged between the agent pot assembly and the atomization generator which are connected through the low-pressure manifold pipeline and the high-pressure liquid inlet pipeline. The high-pressure liquid inlet pipeline is connected with the liquid inlet pipe. The liquid inlet pipes are connected with the metering pump. The gas inlet pipe is connected with the high-pressure gas source through the high-pressure gas inlet pipe. The gas inlet cap is provided with a gas inlet pipe.

Abstract: An electric cylinder driving device includes an electric cylinder outer tube, an electric cylinder inner tube, a ball screw, an electric cylinder piston, a ball screw nut and an elastic oil scraping device. The electric cylinder outer tube is sleeved on the electric cylinder inner tube. The ball screw nut is installed in an upper end of the electric cylinder inner tube. An end of the ball screw is movably connected in the electric cylinder outer tube, and another end of the ball screw matched with the ball screw nut is inserted into the electric cylinder inner tube. The electric cylinder piston is disposed between the electric cylinder outer tube and the electric cylinder inner tube. A lower end of the electric cylinder inner tube is provided with an oil pool. The elastic oil scraping device is disposed between the electric cylinder piston and the electric cylinder outer tube.

Abstract: A self-entry exploitation device and method for marine natural gas hydrates is provided. The exploitation device includes a self-entry structural body (1), a sand control device (2) and a gas-liquid lifting system. The self-entry structural body (1) is a gravity anchor. The sand control device (2) and the gas-liquid lifting system are mounted on the self-entry structural body (1). At least one cavity (21) is formed between the self-entry structural body (1) and the sand control device (2), and the cavity (21) is communicated with at least one channel. The sand control device (2) allows liquid and gas to pass through to enter the cavity (21) and is able to filter out silt. The gas-liquid lifting system includes at least one lifting power device (31) and has an end connected to the cavity (21) and an end extending out through a pipeline.

Abstract: The invention discloses a suction cylinder exploitation device and method for marine natural gas hydrates. The exploitation device comprises an exploitation cylinder, a water pump, a sand control device, a liquid-gas filling system and the like. Through the specially-designed exploitation cylinder and mating devices thereof, the exploitation cylinder can sink below a seabed surface to exploit natural gas hydrates deep below the seabed surface and can be withdrawn. A series of problems such as high well drilling and completion cost of traditional deep-sea drilling exploitation methods, and damage, collapses and sand generation of plain concrete wellbores under the effect of formation pressure are solved, and the limitations that traditional capping depressurization methods can only exploit submarine superficial hydrates and are low in exploitation efficiency are overcome.

Abstract: A pile-side lateral static load device includes a jack system, a liftable jack cart, a loading jack fixing system, and a loading system. The jack system includes a jack body. The jack system is installed on the liftable jack cart through the loading jack fixing system. The loading system is installed on the loading jack fixing system, and the loading system includes counter-pressure loading systems and counter-tension loading systems. The pile-side lateral static load device has a simple structure, is convenient to install and operate, and can complete lateral loading and in-situ tests under different pile diameters, different tonnages and different precisions, so as to facilitate a simulation test of in-situ lateral loading of a pile.

Abstract: A relay optical system 20 for a rigid endoscope includes a lens fixing frame 21 and a plurality of lenses 22. The lens fixing frame 21 has a plurality of tubular bodies 26. The plurality of tubular bodies 26 are joined coaxially to each other. The plurality of lenses 22 are located at positions other than a joint position jp of the tubular bodies 26 in an axis direction of the lens fixing frame 21. The plurality of lenses 22 are located in the lens fixing frame 21 so as to have a coincident optical axis. The plurality of lenses 22 do not include a cemented lens.

Abstract: An atomization generator and a special high-pressure atomization generation device for increasing oil and gas field recovery are provided. The special high-pressure atomization generation device for increasing oil and gas field recovery includes an agent pot assembly, a gear pump, a metering pump, an atomization generator and pipelines. The gear pump is connected with the agent pot assembly through an agent pot liquid inlet pipe. The metering pump is arranged between the agent pot assembly and the atomization generator which are connected through the low-pressure manifold pipeline and the high-pressure liquid inlet pipeline. The high-pressure liquid inlet pipeline is connected with the liquid inlet pipe. The liquid inlet pipes are connected with the metering pump. The gas inlet pipe is connected with the high-pressure gas source through the high-pressure gas inlet pipe. The gas inlet cap is provided with a gas inlet pipe.

Abstract: Provided a method for separating PHA and PHA prepared therefrom. The method comprises the following steps: subjecting a PHA fermentation broth to solid-liquid separation to obtain a thallus precipitate; breaking cell walls of the thallus precipitate, and subjecting obtained wall-broken products to a plate and frame filtration to obtain PHA; a filter cloth for the plate and frame filtration is pre-coated with a PHA layer. The method adopts a plate and frame separation to replace the traditional centrifugal separation to prepare PHA, and the PHA layer is pre-coated on the filter cloth for the plate and frame filtration, thereby overcome the defects in the prior art such as high cost and operational difficulty caused by adopting multiple centrifugal separations; in addition, the method of the present disclosure also exhibits the advantages of high recovery rate of PHA and high purity of the prepared PHA product.

Abstract: A relay optical system 20 for a rigid endoscope comprises a lens fixing frame 21 and a plurality of lenses 22. The lens fixing frame 21 has a plurality of tubular bodies 26. The plurality of tubular bodies 26 are joined coaxially to each other. The plurality of lenses 22 are located at positions other than a joint position jp of the tubular bodies 26 in an axis direction of the lens fixing frame 21. The plurality of lenses 22 are located in the lens fixing frame 21 so as to have a coincident optical axis. The plurality of lenses 22 do not include a cemented lens.

Abstract: Provided a method for separating PHA and PHA prepared therefrom. The method comprises the following steps: subjecting a PHA fermentation broth to solid-liquid separation to obtain a thallus precipitate; breaking cell walls of the thallus precipitate, and subjecting obtained wall-broken products to a plate and frame filtration to obtain PHA; a filter cloth for the plate and frame filtration is pre-coated with a PHA layer. The method adopts a plate and frame separation to replace the traditional centrifugal separation to prepare PHA, and the PHA layer is pre-coated on the filter cloth for the plate and frame filtration, thereby overcome the defects in the prior art such as high cost and operational difficulty caused by adopting multiple centrifugal separations; in addition, the method of the present disclosure also exhibits the advantages of high recovery rate of PHA and high purity of the prepared PHA product.

Abstract: A method for efficiently producing PHA comprising: inoculating PHA fermentation strains into a fermentation medium for fermentation under the condition of being capable of producing PHA through fermentation; subjecting the fermentation broth to a solid-liquid separation to obtain fermentation supernatant and thallus precipitate; breaking the cell walls of the thallus precipitate, and subjecting the wall-broken products to a plate and frame filtration to prepare PHA; pre-coating a filter cloth for the plate and frame filtration with a PHA layer; at least part of the water of the fermentation medium is PHA process wastewater. The method utilizes the PHA process wastewater as at least part of the water of the fermentation medium, and filters and separates the broken thallus with the plate and frame filtration equipment pre-coated with PHA layer to prepare PHA, thereby recycling the high-salt wastewater, reducing costs, and potentially separating PHA on a large scale for industrial production.

Abstract: The present invention provides transgenic plants having increased tolerance to abiotic stress comprising a recombinant nucleic acid molecule, said recombinant nucleic acid molecule comprising a nucleotide sequence encoding miR319 operatively associated with a promoter, a nucleotide sequence that is antisense to a portion of consecutive nucleotides of a nucleotide sequence encoding PCF5, and/or a nucleotide sequence that encodes a portion of consecutive nucleotides of a nucleotide sequence encoding PCF5, which when expressed produces an antisense nucleotide sequence, wherein expression of the nucleotide sequence confers increased tolerance to abiotic stress. Also provided are methods and compositions for making said transgenic plants.

Abstract: The present invention relates to an apparatus for biological sewage treatment, including a concentrated mixed liquor driving device that uses a gas to drive a concentrated mixed liquor to flow. The present invention further relates to a method for biological sewage treatment, including a step of using a gas to drive a concentrated mixed liquor to flow. The gas can be an aeration gas, especially an oxygen-containing aeration gas after aeration treatment. The apparatus and method of the present invention can sufficiently utilize the energy and oxygen of the aeration gas, so that the energy consumption and maintenance cost of whole apparatus are reduced, biological sewage treatment effects are improved, and sludge floating is prevented. In addition, the apparatus of present invention has advantages of high performance, energy saving, high reliability, and good movability.

Abstract: An object of the present invention is to provide a low-cost, miniature, wide-angle high-zoom-ratio zoom lens that has high imaging performance, and an imaging apparatus equipped with the zoom lens. To achieve the object, a zoom lens including a first lens group having positive refracting power, a second lens group having negative refracting power and a third lens group having positive refracting power in order from an object side in which a lens group P having positive refracting power is arranged closer to an image plane side than the third lens group.

Abstract: A wide-angle zoom lens includes: a first lens group having a negative refractive power, a second lens group having positive refractive power, a third lens group having a negative refractive power and a fourth lens group having a positive refractive power in that order from an object side. The second lens group is configured with a front group, a stop and a rear group having a positive refractive power in that order from the object side. Magnification change is performed by changing distances among the lens groups.

Abstract: A zoom lens includes sequentially from an object side, a first lens section G11 having a negative refractive power and a second lens section G12 having a positive refractive power. The first lens section G11 includes sequentially from the object side, a negative lens L111, a negative lens L112, and a positive lens L113. Both surface of the negative lens L112 are aspheric. The second lens section G12 includes sequentially from the object side, a front group G12F having a positive refractive power and a rear group G12R having a positive refractive power. Both surfaces of a negative lens L126 included in the rear group G12R are aspheric. The zoom lens can maintain high imaging performance while achieving size reductions and wide angle views by satisfying given conditions.

Abstract: A zoom lens includes sequentially from an object side, a first lens group having a positive refractive power, a second lens group having a negative refractive power, a third lens group having a positive refractive power, a fourth lens group having a negative refractive power, a fifth lens group having a positive refractive power, and a sixth lens group having a negative refractive power. The zoom lens varies the interval between the lens groups to perform zooming; shifts the second lens group in a direction substantially orthogonal to the optical axis to correct image blur occurring with optical system vibrations; and satisfies given conditions, enabling a compact size and a high zoom ratio to be achieved while improving imaging performance.

Abstract: A pretreatment method is provided, which comprises the following steps: (1) wastewater feed is introduced into a first end of a first aeration basin, and is mixed with a first concentrated mixed liquor to obtain a first mixed liquor; (2) the first mixed liquor is aerated in the aeration stage of the first aeration basin to obtain a second mixed liquor at a second end of the first aeration basin; (3) the second mixed liquor is introduced into a first sedimentation basin to obtain a supernatant and the first concentrated mixed liquor; (4) the supernatant is discharged and at least a part of the first concentrated mixed liquor is returned to the first end of the first aeration basin. At the same time, a sewage treatment method using the wastewater pretreatment method is provided. The pretreatment method can be used steadily for a long time without discharging sludge.

Abstract: A sewage treatment apparatus comprises a first stage equipment for treating sewage feed to obtain a first effluent and a second stage equipment for treating the first effluent to obtain a second effluent. The second stage equipment comprises a mixer (VI) for mixing the first effluent and a flocculation agent to obtain the first effluent containing the flocculation agent and a flocculation-clarification equipment (VII) comprises a first flocculation reaction chamber (A), into which the first effluent containing the flocculation agent is entered and subjected to flocculation reaction to form a mixture of water and dreg; a first separation chamber (C), into which the mixture of water and dreg from the first flocculation reaction chamber (A) is entered and separated to obtain a first part of the second effluent and a first dreg; and a second separation chamber (D), into which part of the first dreg is entered and separated to obtain a second part of the second effluent and a second dreg.