Patents by Inventor Da-Zhi Wang

Da-Zhi Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATING HEART DISEASE IN MUSCULAR DYSTROPHY PATIENTS
    Publication number: 20230047313
    Abstract: Methods of treating or reducing risk of developing cardiomyopathy or heart failure in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of an inhibitor of NADPH oxidase 4 (Nox4).
    Type: Application
    Filed: December 16, 2020
    Publication date: February 16, 2023
    Inventors: Da-Zhi Wang, Zhanpeng Huang, Jianming Liu
  • Methods for inducing cardiomyocyte proliferation
    Patent number: 9885043
    Abstract: Methods for inducing cardiomyocyte proliferation, e.g., in vivo, by administering a composition comprising miRNA17-92 cluster oligonucleotides, e.g., miR-19a oligonucleotides, miR-19b oligonucleotides, or both miR-19a and miR-19b oligonucleotides.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: February 6, 2018
    Assignee: Children's Medical Center Corporation
    Inventors: Da-Zhi Wang, Jinghai Chen
  • Methods for including cardiomyocyte proliferation
    Patent number: 9562229
    Abstract: Methods for inducing cardiomyocyte proliferation, e.g., in vivo, by administering a composition comprising miRNA17-92 cluster oligonucleotides, e.g., miR-19a oligonucleotides, miR-19b oligonucleotides, or both miR-19a and miR-19b oligonucleotides.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: February 7, 2017
    Assignee: Children's Medical Center Corporation
    Inventors: Da-Zhi Wang, Jinghai Chen
  • METHODS FOR INDUCING CARDIOMYOCYTE PROLIFERATION
    Publication number: 20160257955
    Abstract: Methods for inducing cardiomyocyte proliferation, e.g., in vivo, by administering a composition comprising miRNA17-92 cluster oligonucleotides, e.g., miR-19a oligonucleotides, miR-19b oligonucleotides, or both miR-19a and miR-19b oligonucleotides.
    Type: Application
    Filed: March 24, 2016
    Publication date: September 8, 2016
    Inventors: Da-Zhi Wang, Jinghai Chen
  • METHODS FOR INDUCING CARDIOMYOCYTE PROLIFERATION
    Publication number: 20160024501
    Abstract: Methods for inducing cardiomyocyte proliferation, e.g., in vivo, by administering a composition comprising miRNA17-92 cluster oligonucleotides, e.g., miR-19a oligonucleotides, miR-19b oligonucleotides, or both miR-19a and miR-19b oligonucleotides.
    Type: Application
    Filed: February 6, 2014
    Publication date: January 28, 2016
    Inventors: Da-Zhi Wang, Jinghai Chen
  • MicroRNAs that regulate muscle cell proliferation and differentiation
    Patent number: 9072764
    Abstract: The presently disclosed subject matter provides methods and compositions for modulating gene expression in myocytes. Also provided are cells comprising the compositions of the presently disclosed subject matter.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: July 7, 2015
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Da-Zhi Wang, Jianfu Chen
  • METHODS FOR INDUCING CARDIOMYOCYTE PROLIFERATION
    Publication number: 20140219964
    Abstract: Methods for inducing cardiomyocyte proliferation, e.g., in vivo, by administering a composition comprising miRNA17-92 cluster oligonucleotides, e.g., miR-19a oligonucleotides, miR-19b oligonucleotides, or both miR-19a and miR-19b oligonucleotides.
    Type: Application
    Filed: March 14, 2013
    Publication date: August 7, 2014
    Applicant: Children's Medical Center Corporation
    Inventors: Da-Zhi Wang, Jinghai Chen
  • Micrornas that regulate muscle cell proliferation and differentiation
    Patent number: 8431542
    Abstract: The presently disclosed subject matter provides methods and compositions for modulating gene expression in myocytes. Also provided are cells comprising the compositions of the presently disclosed subject matter.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: April 30, 2013
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Da-Zhi Wang, Jianfu Chen
  • Micrornas That Regulate Muscle Cell Proliferation and Differentiation
    Publication number: 20100292297
    Abstract: The presently disclosed subject matter provides methods and compositions for modulating gene expression in myocytes. Also provided are cells comprising the compositions of the presently disclosed subject matter.
    Type: Application
    Filed: December 12, 2006
    Publication date: November 18, 2010
    Inventors: Da-Zhi Wang, Jianfu Chen
  • Methods and compositions relating to a cardiac-specific nuclear regulatory factor
    Patent number: 6962798
    Abstract: The present invention relates to a novel cardiac-specific transcription factor, myocardin. This molecule modulates the development and differentiation of cardiomyocytes and is a potent inhibitor of cell growth. Methods to exploit these observations are provided and include respecifiying non-cardiac cells into cardiac cells, stimulating cardiac tissue regeneration, and methods for treating cardiomyopathies, myocardial infarction.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: November 8, 2005
    Assignee: Board of Regents, The University of Texas System
    Inventors: Eric N. Olson, Da-Zhi Wang
  • Methods and compositions relating to a cardiac-specific nuclear regulatory factor
    Publication number: 20020164735
    Abstract: The present invention relates to a novel cardiac-specific transcription factor, myocardin. This molecule modulates the development and differentiation of cardiomyocytes and is a potent inhibitor of cell growth. Methods to exploit these observations are provided and include respecifiying non-cardiac cells into cardiac cells, stimulating cardiac tissue regeneration, and methods for treating cardiomyopathies, myocardial infarction.
    Type: Application
    Filed: December 21, 2001
    Publication date: November 7, 2002
    Inventors: Eric N. Olson, Da-Zhi Wang