Patents by Inventor Dazhong Fan
Dazhong Fan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230399326Abstract: Disclosed herein are embodiments of a pyrazole compound according to formula I. Compositions comprising the compound, and a method for making the composition also are disclosed. The composition may comprise a carrier, such as a polymer and/or the composition may be a spray-dried formulation. Also disclosed is a method for using the compound and/or composition. The compound and/or composition may be useful to inhibit an IRAK protein and/or to ameliorate, treat and/or prevent an IRAK-associated disease or condition in a subject.Type: ApplicationFiled: August 24, 2023Publication date: December 14, 2023Applicant: Rigel Pharmaceuticals, Inc.Inventors: Lu Chou, Matt Duan, Ihab S. Darwish, Simon Shaw, Somasekhar Bhamidipati, Vanessa Taylor, Yan Chen, Dazhong Fan, Zhushou Luo
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Publication number: 20220306620Abstract: Disclosed herein are embodiments of a pyrazole compound according to formula I. Compositions comprising the compound, and a method for making the composition also are disclosed. The composition may comprise a carrier, such as a polymer and/or the composition may be a spray-dried formulation. Also disclosed is a method for using the compound and/or composition. The compound and/or composition may be useful to inhibit an IRAK protein and/or to ameliorate, treat and/or prevent an IRAK-associated disease or condition in a subject.Type: ApplicationFiled: May 18, 2022Publication date: September 29, 2022Applicant: Rigel Pharmaceuticals, Inc.Inventors: Lu Chou, Matt Duan, Ihab Darwish, Simon Shaw, Somasekhar Bhamidipati, Vanessa Taylor, Yan Chen, Dazhong Fan, Zhushou Luo
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Publication number: 20220288047Abstract: Disclosed herein are embodiments of a method for treating a disease or condition in a subject, comprising administering to the subject, a pyrazole compound according to formula I. The compound may be administered as a composition, such as a spray-dried formulation. The disease or condition may be hidradenitis suppurativa, or a lymphoid neoplasm, and may be chronic myeloid leukemia or chronic myelomonocytic leukemia.Type: ApplicationFiled: March 2, 2022Publication date: September 15, 2022Applicant: Rigel Pharmaceuticals, Inc.Inventors: Lu Chou, Matt Duan, Ihab Darwish, Simon Shaw, Somasekhar Bhamidipati, Vanessa Taylor, Yan Chen, Dazhong Fan, Zhushou Luo
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Patent number: 11370787Abstract: Disclosed herein are embodiments of a pyrazole compound according to formula I. Compositions comprising the compound, and a method for making the composition also are disclosed. The composition may comprise a carrier, such as a polymer and/or the composition may be a spray-dried formulation. Also disclosed is a method for using the compound and/or composition. The compound and/or composition may be useful to inhibit an IRAK protein and/or to ameliorate, treat and/or prevent an IRAK-associated disease or condition in a subject.Type: GrantFiled: August 28, 2020Date of Patent: June 28, 2022Assignee: Rigel Pharmaceuticals, Inc.Inventors: Lu Chou, Matt Duan, Ihab Darwish, Simon Shaw, Somasekhar Bhamidipati, Vanessa Taylor, Yan Chen, Dazhong Fan, Zhushou Luo
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Publication number: 20210061798Abstract: Disclosed herein are embodiments of a pyrazole compound according to formula I. Compositions comprising the compound, and a method for making the composition also are disclosed. The composition may comprise a carrier, such as a polymer and/or the composition may be a spray-dried formulation. Also disclosed is a method for using the compound and/or composition. The compound and/or composition may be useful to inhibit an IRAK protein and/or to ameliorate, treat and/or prevent an IRAK-associated disease or condition in a subject.Type: ApplicationFiled: August 28, 2020Publication date: March 4, 2021Applicant: Rigel Pharmaceuticals, Inc.Inventors: Lu Chou, Matt Duan, Ihab Darwish, Simon Shaw, Somasekhar Bhamidipati, Vanessa Taylor, Yan Chen, Dazhong Fan, Zhushou Luo
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Patent number: 8524892Abstract: A method of making a porphyrin is carried out by: (a) condensing (i) a 1,9-bis(N,N-)dialkylaminomethyl)dipyrromethane of Formula II: with (ii) a dipyrromethane to produce a reaction product; then (b) oxidizing the reaction product; and then (c) optionally demetallating said reaction product to produce the porphyrin. The reaction is particularly useful for making substituted porphyrins with a wide range of substituents at the A and/or B (the 5 and/or 15) positions.Type: GrantFiled: June 5, 2012Date of Patent: September 3, 2013Assignee: North Carolina State UniversityInventors: Jonathan S. Lindsey, Masahiko Taniguchi, Dazhong Fan
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Publication number: 20120253052Abstract: A method of making a porphyrin is carried out by: (a) condensing (i) a 1,9-bis(N,N-)dialkylaminomethyl)dipyrromethane of Formula II: with (ii) a dipyrromethane to produce a reaction product; then (b) oxidizing the reaction product; and then (c) optionally demetallating said reaction product to produce the porphyrin. The reaction is particularly useful for making substituted porphyrins with a wide range of substituents at the A and/or B (the 5 and/or 15) positions.Type: ApplicationFiled: June 5, 2012Publication date: October 4, 2012Inventors: Jonathan S. Lindsey, Masahiko Taniguchi, Dazhong Fan
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Patent number: 8212023Abstract: A method of making a porphyrin is carried out by: (a) condensing (i) a 1,9-bis(N,N-)dialkylaminomethyl)dipyrromethane of Formula II: with (ii) a dipyrromethane to produce a reaction product; then (b) oxidizing the reaction product; and then (c) optionally demetallating said reaction product to produce the porphyrin. The reaction is particularly useful for making substituted porphyrins with a wide range of substituents at the A and/or B (the 5 and/or 15) positions.Type: GrantFiled: January 27, 2011Date of Patent: July 3, 2012Assignee: North Carolina State UniversityInventors: Jonathan S. Lindsey, Masahiko Taniguchi, Dazhong Fan
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Patent number: 8013149Abstract: A method of making a porphyrin (I) is carried out by condensing (i) a bis(imino)dipyrromethane of Formula II: with (ii) a dipyrromethaneto produce a reaction product; then (b) optionally oxidizing said reaction product with an oxidizing agent; and then (c) optionally demetallating said reaction product to produce the porphyrin. Methods of making compounds of Formula II are also described.Type: GrantFiled: June 30, 2009Date of Patent: September 6, 2011Assignee: North Carolina State UniversityInventors: Jonathan S. Lindsey, Masahiko Taniguchi, Arumugham Balakumar, Dazhong Fan
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Publication number: 20110144325Abstract: A method of making a porphyrin is carried out by: (a) condensing (i) a 1,9-bis(N,N-)dialkylaminomethyl)dipyrromethane of Formula II: with (ii) a dipyrromethane to produce a reaction product; then (b) oxidizing the reaction product; and then (c) optionally demetallating said reaction product to produce the porphyrin. The reaction is particularly useful for making substituted porphyrins with a wide range of substituents at the A and/or B (the 5 and/or 15) positions.Type: ApplicationFiled: January 27, 2011Publication date: June 16, 2011Inventors: Jonathan S. Lindsey, Masahiko Taniguchi, Dazhong Fan
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Patent number: 7951939Abstract: A method of making a porphyrin is carried out by: (a) condensing (i) a 1,9-bis(N,N-)dialkylaminomethyl)dipyrromethane of Formula II: with (ii) a dipyrromethane to produce a reaction product; then (b) oxidizing the reaction product; and then (c) optionally demetallating said reaction product to produce the porphyrin. The reaction is particularly useful for making substituted porphyrins with a wide range of substituents at the A and/or B (the 5 and/or 15) positions.Type: GrantFiled: January 29, 2009Date of Patent: May 31, 2011Assignee: North Carolina State UniversityInventors: Jonathan S. Lindsey, Masahiko Taniguchi, Dazhong Fan
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Self-assembled photosynthesis-inspired light harvesting material and solar cells containing the same
Patent number: 7633007Abstract: A solar cell is described that comprises: (a) a semiconductor charge separation material; (b) at least one electrode connected to the charge separation material; and (c) a light-harvesting film on the charge separation material, the light-harvesting film comprising non-covalently coupled, self-assembled units of porphyrinic macrocycles. The porphyrinic macrocycles preferably comprise: (i) an intramolecularly coordinated metal; (ii) a first coordinating substituent; and (iii) a second coordinating substituent opposite the first coordinating substituent. The porphyrinic macrocycles can be assembled by repeating intermolecular coordination complexes of the metal, the first coordinating substituent and the second coordinating substituent.Type: GrantFiled: July 24, 2007Date of Patent: December 15, 2009Assignee: North Carolina State UniversityInventors: Jonathan S. Lindsey, Muthiah Chinnasamy, Dazhong Fan -
Publication number: 20090270638Abstract: A method of making a porphyrin (I) is carried out by condensing (i) a bis(imino)dipyrromethane of Formula II: with (ii) a dipyrromethaneto produce a reaction product; then (b) optionally oxidizing said reaction product with an oxidizing agent; and then (c) optionally demetallating said reaction product to produce the porphyrin. Methods of making compounds of Formula II are also described.Type: ApplicationFiled: June 30, 2009Publication date: October 29, 2009Inventors: Jonathan S. Lindsey, Masahiko Taniguchi, Arumugham Balakumar, Dazhong Fan
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Patent number: 7582751Abstract: A method of making a porphyrin (I) is carried out by condensing (i) a bis(imino)dipyrromethane of Formula II: with (ii) a dipyrromethane to produce a reaction product; then (b) optionally oxidizing said reaction product with an oxidizing agent; and then (c) optionally demetallating said reaction product to produce the porphyrin. Methods of making compounds of Formula II are also described.Type: GrantFiled: July 29, 2005Date of Patent: September 1, 2009Assignee: North Carolina State UniversityInventors: Jonathan S. Lindsey, Masahiko Taniguchi, Arumugham Balakumar, Dazhong Fan
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Publication number: 20090198049Abstract: A method of making a porphyrin is carried out by: (a) condensing (i) a 1,9-bis(N,N-)dialkylaminomethyl)dipyrromethane of Formula II: with (ii) a dipyrromethane to produce a reaction product; then (b) oxidizing the reaction product; and then (c) optionally demetallating said reaction product to produce the porphyrin. The reaction is particularly useful for making substituted porphyrins with a wide range of substituents at the A and/or B (the 5 and/or 15) positions.Type: ApplicationFiled: January 29, 2009Publication date: August 6, 2009Applicant: North Carolina State UniversityInventors: Jonathan S. Lindsey, Masahiko Taniguchi, Dazhong Fan
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Patent number: 7501508Abstract: A method of making a porphyrin is carried out by: (a) condensing (i) a 1,9-bis(N,N-)dialkylaminomethyl)dipyrromethane of Formula II: with (ii) a dipyrromethane to produce a reaction product; then (b) oxidizing the reaction product; and then (c) optionally demetallating said reaction product to produce the porphyrin. The reaction is particularly useful for making substituted porphyrins with a wide range of substituents at the A and/or B (the 5 and/or 15) positions.Type: GrantFiled: July 29, 2005Date of Patent: March 10, 2009Assignee: North Caroline State UniversityInventors: Jonathan S. Lindsey, Masahiko Taniguchi, Dazhong Fan
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SELF-ASSEMBLED PHOTOSYNTHESIS-INSPIRED LIGHT HARVESTING MATERIAL AND SOLAR CELLS CONTAINING THE SAME
Publication number: 20080029155Abstract: A solar cell is described that comprises: (a) a semiconductor charge separation material; (b) at least one electrode connected to the charge separation material; and (c) a light-harvesting film on the charge separation material, the light-harvesting film comprising non-covalently coupled, self-assembled units of porphyrinic macrocycles. The porphyrinic macrocycles preferably comprise: (i) an intramolecularly coordinated metal; (ii) a first coordinating substituent; and (iii) a second coordinating substituent opposite the first coordinating substituent. The porphyrinic macrocycles can be assembled by repeating intermolecular coordination complexes of the metal, the first coordinating substituent and the second coordinating substituent.Type: ApplicationFiled: July 24, 2007Publication date: February 7, 2008Inventors: Jonathan Lindsey, Muthiah Chinnasamy, Dazhong Fan -
Publication number: 20070027311Abstract: A method of making a porphyrin is carried out by: (a) condensing (i) a 1,9-bis(N,N-)dialkylaminomethyl)dipyrromethane of Formula II: with (ii) a dipyrromethane to produce a reaction product; then (b) oxidizing the reaction product; and then (c) optionally demetallating said reaction product to produce the porphyrin. The reaction is particularly useful for making substituted porphyrins with a wide range of substituents at the A and/or B (the 5 and/or 15) positions.Type: ApplicationFiled: July 29, 2005Publication date: February 1, 2007Inventors: Jonathan Lindsey, Masahiko Taniguchi, Dazhong Fan
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Publication number: 20070027312Abstract: A method of making a porphyrin (I) is carried out by condensing (i) a bis(imino)dipyrromethane of Formula II: with (ii) a dipyrromethaneto produce a reaction product; then (b) optionally oxidizing said reaction product with an oxidizing agent; and then (c) optionally demetallating said reaction product to produce the porphyrin. Methods of making compounds of Formula II are also described.Type: ApplicationFiled: July 29, 2005Publication date: February 1, 2007Inventors: Jonathan Lindsey, Masahiko Taniguchi, Arumugham Balakumar, Dazhong Fan