Patents by Inventor De Gao

De Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11904303
    Abstract: A method of forming an AFX zeolite in a hydrothermal synthesis that exhibits a silica to alumina (SiO2AI2O3) molar ratio (SAR) that is between 8:1 and 26:1; has a morphology that includes one or more of cubic, spheroidal, or rhombic particles with a crystal size that is in the range of about 0.1 micrometer (?m) to 10 ?m. This AFX zeolite also exhibits a Brönsted acidity that is in the range of 1.2 mmol/g to 3.6 mmol/g as measured by ammonia temperature programmed desorption. A catalyst formed by substituting a metal into the framework of the zeolite exhibits about a 100% conversion of NO emissions over the temperature range of 300° C. to 650° C.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: February 20, 2024
    Assignee: Pacific Industrial Development Corporation
    Inventors: De Gao, Yunkui Li, David Shepard, Jeffery Lachapelle, Wei Wu
  • Publication number: 20240046097
    Abstract: A computer-implemented method for compressing a machine learning model includes converting an input machine learning model into a standard machine learning model. The method further includes converting the standard machine learning model into a plurality of pruned machine learning models, each of the pruned machine learning models converted using a corresponding pruning ratio from a pruning ratio candidate list. The method further includes determining, for each of the pruned machine learning models, a size-to-error ratio. The method further includes selecting, based on the size-to-error ratio of the pruned machine learning models, a first pruning ratio from the pruning ratio candidate list. The method further includes generating a compressed machine learning model by compressing the input machine learning model using the first pruning ratio that is selected. The method further includes deploying the compressed machine learning model for production.
    Type: Application
    Filed: August 5, 2022
    Publication date: February 8, 2024
    Inventors: De Gao Chu, Lin Dong, Xiao Tian Xu, Xue Yin Zhuang
  • Patent number: 11883804
    Abstract: A method of forming an SSZ-13 zeolite in a hydrothermal synthesis yields an SSZ-13 zeolite that exhibits a silica to alumina (SiO2:Al2O3) molar ratio (SAR) that is less than 16:1; has a morphology that includes one or more of cubic, spheroidal, or rhombic particles with a crystal size that is in the range of about 0.1 micrometer (?m) to 10 ?m. This SSZ-13 also exhibits a Brönsted acidity that is in the range of 2.0 mmol/g to 3.4 mmol/g as measured by ammonia temperature programmed desorption. A catalyst formed by substituting a metal into the framework of the zeolite provides for low temperature light-off of the NOx conversion reactions, while maintaining substantial performance at higher temperatures demonstrating hydrothermal stability.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: January 30, 2024
    Assignee: Pacific Industrial Development Corporation
    Inventors: De Gao, Yunkui Li, David Shepard, Jeffery Lachapelle, Wei Wu
  • Patent number: 11771651
    Abstract: Disclosed herein are novel synthetic polypeptides and uses thereof in the preparation of liposomes. According to embodiments of the present disclosure, the synthetic polypeptide comprises a membrane lytic motif, a masking motif, and a linker configured to link the membrane lytic motif and the masking motif. The linker is cleavable by a stimulus, such as, light, protease, or phosphatase. Once being coupled to a liposome, the exposure to the stimulus cleaves the linker that results in the separation of the masking motif from the membrane lytic motif, which in turn exerts membrane lytic activity on the liposome that leads to the collapse of the intact structure of the liposome, and releases the agent encapsulated in the liposome to the target site. Also disclosed herein are methods of diagnosing or treating a disease in a subject by use of the present liposomes.
    Type: Grant
    Filed: January 28, 2022
    Date of Patent: October 3, 2023
    Assignee: Academia Sinica
    Inventors: Hsien-Ming Lee, Hua-De Gao, Jia-Lin Hong, Chih-Yu Kuo, Cheng-Bang Jian
  • Publication number: 20220151926
    Abstract: Disclosed herein are novel synthetic polypeptides and uses thereof in the preparation of liposomes. According to embodiments of the present disclosure, the synthetic polypeptide comprises a membrane lytic motif, a masking motif, and a linker configured to link the membrane lytic motif and the masking motif. The linker is cleavable by a stimulus, such as, light, protease, or phosphatase. Once being coupled to a liposome, the exposure to the stimulus cleaves the linker that results in the separation of the masking motif from the membrane lytic motif, which in turn exerts membrane lytic activity on the liposome that leads to the collapse of the intact structure of the liposome, and releases the agent encapsulated in the liposome to the target site. Also disclosed herein are methods of diagnosing or treating a disease in a subject by use of the present liposomes.
    Type: Application
    Filed: January 28, 2022
    Publication date: May 19, 2022
    Applicant: Academia Sinica
    Inventors: Hsien-Ming LEE, Hua-De GAO, Jia-Lin HONG, Chih-Yu KUO, Cheng-Bang JIAN
  • Publication number: 20220153600
    Abstract: A method of continuously forming AEI-type zeolites in a tubular reactor via a hydrothermal synthesis. A gel composition formed upon using this method includes one or more sources of silica, alumina, organic structure directing agents (OSDA), alkali metal ions; water; and optionally zeolite seeds. This gel composition is defined by the molar ratios of SiO2/AI2O3 15:1 to 100:1; M2O/SiO2 0.15:1 to 0.30:1; ROH/SiO2 0.05:1 to 0.2:1; and H2O/SiO2 5:1 to 20:1; wherein M is the alkali metal ion and R is an organic moiety derived from the OSDA. This gel composition, after reacting at a temperature between 180° C. to about 220° C. for less than 2 hours forms the crystalline AEI-type zeolite having a silica to alumina ratio (SiO2/AI2O3) that is greater than 14:1.
    Type: Application
    Filed: April 9, 2020
    Publication date: May 19, 2022
    Inventors: Yunkui Li, Wei Wu, De Gao, David Shepard, Jeffery Lachapelle, Geng Zhang
  • Patent number: 11266603
    Abstract: Disclosed herein are novel synthetic polypeptides and uses thereof in the preparation of liposomes. According to embodiments of the present disclosure, the synthetic polypeptide comprises a membrane lytic motif, a masking motif, and a linker configured to link the membrane lytic motif and the masking motif. The linker is cleavable by a stimulus, such as, light, protease, or phosphatase. Once being coupled to a liposome, the exposure to the stimulus cleaves the linker that results in the separation of the masking motif from the membrane lytic motif, which in turn exerts membrane lytic activity on the liposome that leads to the collapse of the intact structure of the liposome, and releases the agent encapsulated in the liposome to the target site. Also disclosed herein are methods of diagnosing or treating a disease in a subject by use of the present liposomes.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: March 8, 2022
    Inventors: Hsien-Ming Lee, Hua-De Gao, Jia-Lin Hong, Chih-Yu Kuo, Cheng-Bang Jian
  • Publication number: 20210403334
    Abstract: A method of forming AEI-type zeolites in a hydrothermal synthesis without the use of hydrogen fluoride (HF) and in the presence of an FAU zeolite NaY with SAR ?5, a Y zeolite with a SAR ?5, or a combination thereof. A gel composition formed upon using this method includes one or more sources of silica, alumina, organic structure directing agents (OSDA), and alkali metal ions; zeolite seeds; and water. This gel composition is defined by the molar ratios of: SiO2/AI2O3 18:1 to 100:1; M2O/SiO2 0.15:1 to 0.30:1; ROH/SiO2 0.05:1 to 0.13:1; and H2O/SiO2 5:1 to 20:1; wherein M is the alkali metal ion and R is an organic moiety derived from the OSDA. This gel composition, after reacting at a temperature between 135° C. to about 200° C. for 10 hours to 168 hours forms the crystalline AEI-type zeolite having a silica to alumina ratio (SiO2:AI2O3) that is greater than 15:1.
    Type: Application
    Filed: November 4, 2019
    Publication date: December 30, 2021
    Inventors: Yunkui Li, De Gao, David Shepard, Wei Wu, Jeffery Lachapelle, Geng Zhang
  • Publication number: 20210394165
    Abstract: A method of forming an AFX zeolite in a hydrothermal synthesis that exhibits a silica to alumina (SiO2AI2O3) molar ratio (SAR) that is between 8:1 and 26:1; has a morphology that includes one or more of cubic, spheroidal, or rhombic particles with a crystal size that is in the range of about 0.1 micrometer (?m) to 10 ?m. This AFX zeolite also exhibits a Brönsted acidity that is in the range of 1.2 mmol/g to 3.6 mmol/g as measured by ammonia temperature programmed desorption. A catalyst formed by substituting a metal into the framework of the zeolite exhibits about a 100% conversion of NO emissions over the temperature range of 300° C. to 650° C.
    Type: Application
    Filed: November 8, 2019
    Publication date: December 23, 2021
    Inventors: De Gao, Yunkui Li, David Shepard, Jeffery Lachapelle, Wei Wu
  • Publication number: 20210339233
    Abstract: A method of forming an SSZ-13 zeolite in a hydrothermal synthesis yields an SSZ-13 zeolite that exhibits a silica to alumina (SiO2:Al2O3) molar ratio (SAR) that is less than 16:1; has a morphology that includes one or more of cubic, spheroidal, or rhombic particles with a crystal size that is in the range of about 0.1 micrometer (?m) to 10 ?m. This SSZ-13 also exhibits a Brönsted acidity that is in the range of 2.0 mmol/g to 3.4 mmol/g as measured by ammonia temperature programmed desorption. A catalyst formed by substituting a metal into the framework of the zeolite provides for low temperature light-off of the NOx conversion reactions, while maintaining substantial performance at higher temperatures demonstrating hydrothermal stability.
    Type: Application
    Filed: October 24, 2019
    Publication date: November 4, 2021
    Inventors: De Gao, Yunkui Li, David Shepard, Jeffery Lachapelle, Wei Wu
  • Publication number: 20210323832
    Abstract: A method of forming an AEI-type zeolite in a hydrothermal synthesis without the use of hydrogen fluoride (HF) and in the absence of any FAU zeolite Y. A gel composition formed upon using this method includes one or more sources of silica; one or more sources of alumina, one or more organic structure directing agents (OSDA); a source of alkali metal ions; and water. This gel composition is defined by the molar ratios of: SiO2/AI2O3 16:1 to 100:1; M2O/SiO2 0.15:1 to 0.30:1; ROH/SiO2 0.05:1 to 0.20:1; and H2O/SiO2 5:1 to 20:1; wherein M is the alkali metal ion and R is an organic moiety derived from the OSDA. This gel composition, after reacting at a temperature between 135° C. to about 180° C. for 15 hours to 168 hours forms the crystalline AEI-type zeolite having a silica to alumina ratio (SiO2:AI2O3) that is greater than 8:1.
    Type: Application
    Filed: August 23, 2019
    Publication date: October 21, 2021
    Inventors: Yunkui Li, David Shepard, De Gao, Wei Wu, Jeffery Lachapelle, Geng Zhang
  • Publication number: 20200000722
    Abstract: Disclosed herein are novel synthetic polypeptides and uses thereof in the preparation of liposomes. According to embodiments of the present disclosure, the synthetic polypeptide comprises a membrane lytic motif, a masking motif, and a linker configured to link the membrane lytic motif and the masking motif. The linker is cleavable by a stimulus, such as, light, protease, or phosphatase. Once being coupled to a liposome, the exposure to the stimulus cleaves the linker that results in the separation of the masking motif from the membrane lytic motif, which in turn exerts membrane lytic activity on the liposome that leads to the collapse of the intact structure of the liposome, and releases the agent encapsulated in the liposome to the target site. Also disclosed herein are methods of diagnosing or treating a disease in a subject by use of the present liposomes.
    Type: Application
    Filed: June 28, 2019
    Publication date: January 2, 2020
    Applicant: Academia Sinica
    Inventors: Hsien-Ming LEE, Hua-De GAO, Jia-Lin HONG, Chih-Yu KUO, Cheng-Bang JIAN
  • Publication number: 20190336954
    Abstract: A crystalline, core-shell hybrid Chabazite (CHA) material for use as a catalyst has a core with a silicon to aluminum ratio (SAR) that is less than 25 and a shell that at least partially encapsulates the core, the shell having an SAR of about 25 or greater. The crystalline, core-shell hybrid Chabazite is prepared by forming a first chabazite (CHA) material having a silicon to aluminum ratio (SAR) that is less than 25, placing the first CHA material into an aqueous reaction mixture comprising one or more precursors capable of forming a second chabazite (CHA) material having an SAR that is 25 or greater, growing the second CHA material on the surface of the first CHA material, and collecting the core-shell hybrid CHA material.
    Type: Application
    Filed: May 1, 2018
    Publication date: November 7, 2019
    Inventors: Wei Wu, Geng Zhang, De Gao, David Shepard, Yunkui Li, Jeffery Lachapelle
  • Patent number: 5240481
    Abstract: A programmable control and operation system is applied in a swing pressure adsorption process. The system comprises a computer, a driving device, and a plurality of programmable control valve assemblies. The programmable control valve assembly comprises an operating valve with at least one cavity for sealing control, a valve core, a sealing ring, an operation device, a sealing control valve, and a valve position detector. The operation of the sealing control valve is dependent on the open or closed position of the valve and the process of opening and closing the valve. The sealing control valve feeds a sealing control medium at a pressure to the cavity for sealing the operating valve. The sealing control medium acts on the sealing ring to increase the pressure at the valve core to seal the operating valve. The control and operation system provide independent control of the sealing valve and operating valve to increase reliability and durability.
    Type: Grant
    Filed: August 3, 1992
    Date of Patent: August 31, 1993
    Assignee: Chengdu Huaxi Chemical Engineering Research Institute
    Inventors: Dong-Lin Li, Yi-Jiang Tang, Jiong-Liang Yang, Chong-Gang Zhang, De-Gao He