Patents by Inventor De-Qi Xu

De-Qi Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Live, oral vaccine for protection against serotype 1
    Patent number: 9402889
    Abstract: The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2 and species homologs thereof; b) DNA encoding Shigella dysenteriae serotype 1 polypeptides encoded by any one of SEQ ID NOs: 1 and 2, and species homologs thereof; and c) DNA encoding a O antigen biosynthesis gene product that hybridizes under moderately stringent conditions to the DNA of (a) or (b); and related sequences, compositions of matter, vaccines, methods of using, and methods of making.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: August 2, 2016
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Dennis J. Kopecko, De-Qi Xu
  • Vaccine for protection against disease
    Patent number: 9333251
    Abstract: Compositions and methods for protecting a susceptible host against an infection of Shigella sonnei are disclosed. Such compositions and methods are useful for protecting the host against bacillary dysentery and shigellosis.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: May 10, 2016
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Dennis J. Kopecko, De-Qi Xu, John O. Cisar
  • VACCINE FOR PROTECTION AGAINST SHIGELLA SONNEI DISEASE
    Publication number: 20150182611
    Abstract: Compositions and methods for protecting a susceptible host against an infection of Shigella sonnei are disclosed. Such compositions and methods are useful for protecting the host against bacillary dysentery and shigellosis.
    Type: Application
    Filed: March 17, 2015
    Publication date: July 2, 2015
    Inventors: Dennis J. KOPECKO, De-Qi XU, John O. CISAR
  • LIVE, ORAL VACCINE FOR PROTECTION AGAINST SHIGELLA DYSENTERIAE SEROTYPE 1
    Publication number: 20150182610
    Abstract: The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2 and species homologs thereof; b) DNA encoding Shigella dysenteriae serotype 1 polypeptides encoded by any one of SEQ ID NOs: 1 and 2, and species homologs thereof; and c) DNA encoding a O antigen biosynthesis gene product that hybridizes under moderately stringent conditions to the DNA of (a) or (b); and related sequences, compositions of matter, vaccines, methods of using, and methods of making.
    Type: Application
    Filed: December 30, 2014
    Publication date: July 2, 2015
    Inventors: DENNIS J. KOPECKO, DE-QI XU
  • Vaccine for protection against disease
    Patent number: 8992943
    Abstract: Compositions and methods for protecting a susceptable host against an infection of Shigella sonnei are disclosed. Such compositions and methods are useful for protecting the host against bacillary dysentery and shigellosis.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: March 31, 2015
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Dennis J. Kopecko, De-Qi Xu, John O. Cisar
  • Live, oral vaccine for protection against serotype 1
    Patent number: 8968719
    Abstract: The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2 and species homologs thereof; b) DNA encoding Shigella dysenteriae serotype 1 polypeptides encoded by any one of SEQ ID NOs: 1 and 2, and species homologs thereof; and c) DNA encoding a O antigen biosynthesis gene product that hybridizes under moderately stringent conditions to the DNA of (a) or (b); and related sequences, compositions of matter, vaccines, methods of using, and methods of making.
    Type: Grant
    Filed: December 31, 2013
    Date of Patent: March 3, 2015
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Sevices
    Inventors: Dennis J. Kopecko, De-Qi Xu
  • Live, oral vaccine for protection against serotype 1
    Patent number: 8790635
    Abstract: The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2 and species homologs thereof; b) DNA encoding Shigella dysenteriae serotype 1 polypeptides encoded by any one of SEQ ID NOs: 1 and 2, and species homologs thereof; and c) DNA encoding a O antigen biosynthesis gene product that hybridizes under moderately stringent conditions to the DNA of (a) or (b); and related sequences, compositions of matter, vaccines, methods of using, and methods of making.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: July 29, 2014
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Dennis J. Kopecko, De-Qi Xu
  • LIVE, ORAL VACCINE FOR PROTECTION AGAINST SHIGELLA DYSENTERIAE SEROTYPE 1
    Publication number: 20140120134
    Abstract: The invention relates to Salmonella typhi Ty21a comprising core-linked Shigella dysenteriae serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2 and species homologs thereof; b) DNA encoding Shigella dysenteriae serotype 1 polypeptides encoded by any one of SEQ ID NOs: 1 and 2, and species homologs thereof; and c) DNA encoding a O antigen biosynthesis gene product that hybridizes under moderately stringent conditions to the DNA of (a) or (b); and related sequences, compositions of matter, vaccines, methods of using, and methods of making.
    Type: Application
    Filed: December 31, 2013
    Publication date: May 1, 2014
    Applicant: The Government of The U.S.A, as represented by the Secretary. Dept. of Health and Human Services
    Inventors: Dennis J. KOPECKO, De-Qi XU
  • VACCINE FOR PROTECTION AGAINST SHIGELLA SONNEI DISEASE
    Publication number: 20120058142
    Abstract: Compositions and methods for protecting a susceptable host against an infection of Shigella sonnei are disclosed. Such compositions and methods are useful for protecting the host against bacillary dysentery and shigellosis.
    Type: Application
    Filed: November 14, 2011
    Publication date: March 8, 2012
    Applicant: Government of The United States of America, as represented by the The Secretary
    Inventors: DENNIS J. KOPECKO, De-Qi XU, JOHN O. CISAR
  • Vaccine for protection against disease
    Patent number: 8071084
    Abstract: Compositions and methods for protecting a susceptible host against an infection of Shigella sonnei are disclosed. Such compositions and methods are useful for protecting the host against bacillary dysentery and shigellosis.
    Type: Grant
    Filed: May 28, 2009
    Date of Patent: December 6, 2011
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Dennis J. Kopecko, De-Qi Xu, John O. Cisar
  • VACCINE FOR PROTECTION AGAINST SHIGELLA SONNEI DISEASE
    Publication number: 20100272748
    Abstract: Compositions and methods for protecting a susceptible host against an infection of Shigella sonnei are disclosed. Such compositions and methods are useful for protecting the host against bacillary dysentery and shigellosis.
    Type: Application
    Filed: May 28, 2009
    Publication date: October 28, 2010
    Applicant: THE GOVERNMENT OF THE U.S.A., AS REPRESENTED BY SECRETARY OF HEALTH AND HUMAN SERVICES
    Inventors: DENNIS J. KOPECKO, DE-QI XU, JOHN O. CISAR
  • Vaccine for protection against disease
    Patent number: 7541043
    Abstract: Compositions and methods for protecting a susceptable host against an infection of Shigella sonnei are disclosed. Such compositions and methods are useful for protecting the host against bacillary dysentery and shigellosis.
    Type: Grant
    Filed: January 15, 2003
    Date of Patent: June 2, 2009
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Dennis J. Kopecko, De-Qi Xu, John O. Cisar
  • Vaccine for protection against Shigella sonnei disease
    Publication number: 20050281841
    Abstract: Compositions and methods for protecting a susceptable host against an infection of Shigella sonnei are disclosed. Such compositions and methods are useful for protecting the host against bacillary dysentery and shigellosis.
    Type: Application
    Filed: January 15, 2003
    Publication date: December 22, 2005
    Inventors: Dennis Kopecko, De-Qi Xu, John Cisar