Abstract: The invention relates to nucleic acid molecules for pseudouridylation of a target uridine in a target RNA in a mammalian cell, wherein the nucleic acid molecule comprises a guide region capable of forming a partially double stranded nucleic acid complex with the target RNA comprising the target uridine, wherein the partially double stranded nucleic acid complex is capable of engaging a mammalian pseudouridylation enzyme, wherein the guide region assists in positioning the target uridine in the partially double stranded nucleic acid complex for it to be converted to a pseudouridine by the mammalian pseudouridylation enzyme.

Abstract: An electromagnetic interference (EMI) shielded device which includes an object to be shielded and an EMI shielding material encompassing the object. The EMI shielding material is made up of, but not limited to a broadband biopolymer or polymer dissolved in organic solvents and shielding guest material. The specific makeup of the shielding material and fabrication procedure of the shielding material is also included herein.

Abstract: A double-sided composite spectacle lens and an inject mold therefor are provided. One surface of the spectacle lens is an aspherical surface, and the other surface is a designed aspherical surface used to inhibit astigmatism, and a spectacle lens formed by combining the two surfaces has two areas with different functions: optimizing optical performance, and thinning for aesthetics. By controlling the reduction of diopter and optimizing astigmatism on one surface, and inversely offsetting astigmatism on the other surface, the degree of astigmatism of the spectacle lens formed by combining the two surfaces is significantly lower than a diopter variation, and the degree of oblique astigmatism is significantly reduced. The aesthetic thinning effects of reducing the edge or center thickness of the double-sided composite spectacle lens are significantly enhanced by accelerating reduction of the diopter on one surface and changing from reducing to increasing the diopter on the other surface.

Abstract: A display substrate includes: a base substrate; a plurality of sub-pixels, each sub-pixel including a light-emission device including a first electrode; a plurality of signal lines including at least a first signal line and a second signal line; a signal line lead in a non-display area; and a signal line transfer structure on the base substrate, wherein the signal line transfer structure is configured to connect the signal line lead and the second signal line, the signal line transfer structure and the first signal line are located in the same layer, and the signal line transfer structure is spaced apart from the first signal line. An orthographic projection of the first electrode of at least one of the sub-pixels on the base substrate at least partially overlaps with an orthographic projection of each of the first signal line and the signal line transfer structure on the base substrate.

Abstract: Apparatuses, systems, and techniques to perform neural networks. In at least one embodiment, a most consistent output of one or more pre-trained neural networks is to be selected. In at least one embodiment, a most consistent output of one or more pre-trained neural networks is to be selected based, at least in part, on a plurality of variances of one or more inputs to the one or more neural networks.

Abstract: A double-sided loudspeaker includes a first speaker base and a second speaker base assembled with each other and provided with a ventilation hole; a first side magnetic plate injection molded at the first speaker base or the second speaker base; a second side magnetic plate injection molded at the first speaker base or the second speaker base; a magnetic member disposed between the first side magnetic plate and the second side magnetic plate and including a main magnetic plate, a first magnetic unit and a second magnetic unit; a first diaphragm disposed at the first speaker base; a first voice coil disposed at the first diaphragm and movably arranged at the first magnetic unit; a second diaphragm disposed at the second speaker base; and a second voice coil disposed at the second diaphragm and movably arranged at the second magnetic unit.

Abstract: Embodiments of the present invention relate to methods, systems, and computer program products for managing a plurality of live comments. A plurality of live comments is obtained for a video, the plurality of live comments being associated with a plurality of fragments in the video, respectively. A plurality of features are extracted from the plurality of live comments, respectively. A knowledge base is generated for the plurality of live comments based on the plurality of features. With these embodiments, the live comments may be managed in an effective way. Further, the knowledge base may provide answers to a user query.

Abstract: An electromagnetic interference (EMI) shielded device which includes an object to be shielded and an EMI shielding material encompassing the object. The EMI shielding material is made up of, but not limited to a broadband biopolymer or polymer dissolved in organic solvents and shielding guest material. The specific makeup of the shielding material and fabrication procedure of the shielding material is also included herein.

Abstract: Devices and methods are disclosed for managing and/or treating body tissues obstructing a hollow body lumen, including the prostatic lobe tissues obstructing the urethra, for example conditions including benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), benign prostatic obstruction (BPO) and associated lower urinary tract symptoms (LUTS). A prostatic implant deployment and delivery system may have a controlled release mechanism, a handle mechanism and an irrigation system. The controlled release mechanism includes a disengageable connection between a pusher member and the prostatic implant with a control member. The handle mechanism includes a plunger for advancing the pusher member and an actuator for withdrawing the control member. The irrigation system may define two fluid paths.

Abstract: Devices and methods are disclosed for determining prostatic urethral length. A measuring device having an elongated shaft member with associated markings may be advanced through a working channel of the cystoscope so that a positioning aid disposed on the elongated shaft member is located at a bladder neck of the patient. A first position of the elongated shaft member is determined using the markings. The elongated shaft member is then withdrawn to a second position at which the positioning aid is located at the patient's verumontanum. The prostatic urethral length is determined based at least in part on relative translational movement of the elongated shaft member between the first position and the second position using the markings.

Abstract: Devices and methods are disclosed for determining prostatic urethral length. A measuring device having an elongated shaft member with associated markings may be advanced through a working channel of the cystoscope so that a positioning aid disposed on the elongated shaft member is located at a bladder neck of the patient. A first position of the elongated shaft member is determined using the markings. The elongated shaft member is then withdrawn to a second position at which the positioning aid is located at the patient's verumontanum. The prostatic urethral length is determined based at least in part on relative translational movement of the elongated shaft member between the first position and the second position using the markings.

Abstract: Devices and methods are disclosed for determining prostatic urethral length. A measuring device having an elongated shaft member with associated markings may be advanced through a working channel of the cystoscope so that a positioning aid disposed on the elongated shaft member is located at a bladder neck of the patient. A first position of the elongated shaft member is determined using the markings. The elongated shaft member is then withdrawn to a second position at which the positioning aid is located at the patient's verumontanum. The prostatic urethral length is determined based at least in part on relative translational movement of the elongated shaft member between the first position and the second position using the markings.

Abstract: An injection device includes a case body, a control circuit disposed on the outside of the case body, a movable part disposed in the case body, carrying a drug, and movable between a start position and a target position, a magnetic member movable along with the movable part and producing a magnetic field, and a magnetic switch disposed on the outside of the case body and connected to the control circuit. When the movable part is moved to the target position, the magnetic switch changes a status of a conductive path of the magnetic switch in response to a presence of the magnetic field. The control circuit changes a state of the injection device according to a change of the status of the conductive path.

Abstract: The present disclosure is relates to an artificial leather and a manufacturing method thereof. The artificial leather includes a substrate, an adhering glue layer, a moldable surface layer, a TPU adhering layer, a TPU layer and a bottom layer. The substrate includes a first surface and a second surface. The adhering glue layer is disposed on the first surface of the substrate. The moldable surface layer is disposed on the adhering glue layer. The TPU adhering layer is disposed on the second surface of the substrate. The TPU is disposed on a surface of the TPU adhering layer. The bottom layer is disposed on a surface of the TPU layer. The moldable surface layer of the artificial leather has a texture of leather and color effect. The bottom layer has a villus effect and high wear resistance.

Abstract: An electromagnetic interference (EMI) shielded device which includes an object to be shielded and an EMI shielding material encompassing the object. The EMI shielding material is made up of, but not limited to a broadband biopolymer or polymer dissolved in organic solvents and shielding guest material. The specific makeup of the shielding material and fabrication procedure of the shielding material is also included herein.

Abstract: An electromagnetic interference (EMI) shielded device which includes an object to be shielded and an EMI shielding material encompassing the object. The EMI shielding material is made up of, but not limited to a broadband biopolymer or polymer dissolved in organic solvents, and metal and carbon-based nano-powders or nanoparticles. The specific makeup of the shielding material and fabrication procedure of the shielding material is also included herein.

Abstract: An electromagnetic interference (EMI) shielded device which includes an object to be shielded and an EMI shielding material encompassing the object. The EMI shielding material is made up of, but not limited to a broadband biopolymer or polymer dissolved in organic solvents, and metal and carbon-based nano-powders or nanoparticles. The specific makeup of the shielding material and fabrication procedure of the shielding material is also included herein.

Abstract: An electromagnetic interference (EMI) shielded device which includes an object to be shielded and an EMI shielding material encompassing the object. The EMI shielding material is made up of, but not limited to a broadband biopolymer or polymer dissolved in organic solvents, and metal and carbon-based nano-powders or nanoparticles. The specific makeup of the shielding material and fabrication procedure of the shielding material is also included herein.

Abstract: The present disclosure provides a cloth attaching device and a cloth attaching method. The cloth attaching device comprises: a cylindrical base, a rubbing roller opposing the cylindrical base and an actuating unit, an annular adhesive layer covering a cylindrical surface of the cylindrical base; a first connecting component holding both ends of the cylindrical base and connecting to the actuating unit; and a second connecting component holding both ends of the robbing roller and connecting to the actuating unit. The actuating unit is configured to control a movement of the first connecting component and the second connecting component so that the rubbing roller and the cylindrical base rotate in sync or not in sync. The present disclosure overcomes defects in which the rubber pad displaces very easily and the aging process is very time consuming, which facilitates to improve fabricating efficiency and quality of the rubbing roller.

Abstract: The present invention provides a liquid crystal display substrate and a preparation method thereof, which belongs to the technical field of liquid crystal display and may solve the problem that vias in the existing liquid crystal display substrate will result in non-uniform thickness of an alignment layer and thus influence the display effect. The liquid crystal display substrate provided by the present invention comprises a plurality of display structures, and an alignment layer located above all the display structures, wherein at least some of the display structures are provided therein with vias, and at least some of the vias are surrounded by baffle walls that are located under the alignment layer.