Abstract: A device for positioning a probe, such as a temperature sensor, in a flask for freeze drying. The device includes a stopper adapted to be secured to an open end of the flask. The stopper has a center opening and at least one radial opening spaced from the center opening. The radial opening allows for fluid communication between inside and outside of the flask when the stopper is secured to the open end of the flask. The center opening receives a guide tube which extends into the flask and is sized to receive the probe such that substantially no fluid communication between the inside of the flask and the outside of the flask occurs through the guide tube or center opening. A channel formed in an upper surface of the stopper and an O-ring positioned about an outer diameter of a neck of the flask secure the probe in position relative to the guide tube. The multiple radial openings define an annular passageway which mimics fluid communication through a standard slit-type stopper employed in freeze drying.

Abstract: The present invention provides a high speed homogenizer which has an adjustable gripping means to grip and hold containers of varying size. This gripping and holding means can be centered or decentered under the homogenizing tool. Decentering a container held by the gripping and holding means tends to minimize or even eliminate vortexing problems. The homogenizer also has electronic means for controlling the speed and time of operation of the homogenizing tool. The electronic control means of the homogenizer can also monitor the temperature of the sample being homogenized and respond to changes in temperature when necessary. The homogenizer can be easily adjusted up and down a vertical support post by a counter weighting mechanism such as a constant force spring.