Patents by Inventor Dean G. Stathakis

Dean G. Stathakis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF ACTIVATING CLOSTRIDIAL TOXINS
    Publication number: 20150232905
    Abstract: The specification discloses modified Clostridial toxins comprising an exogenous Clostridial toxin di-chain loop protease cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified Clostridial toxins; method of producing such modified Clostridial toxins, method of activating such modified Clostridial toxins and methods of activating recombinantly-expressed Clostridial toxins.
    Type: Application
    Filed: May 4, 2015
    Publication date: August 20, 2015
    Inventors: Marc F. Verhagen, Dean G. Stathakis, Lance E. Steward
  • METHODS OF ACTIVATING CLOSTRIDIAL TOXINS
    Publication number: 20130288336
    Abstract: The specification discloses modified Clostridial toxins comprising an exogenous Clostridial toxin di-chain loop protease cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified Clostridial toxins; method of producing such modified Clostridial toxins, method of activating such modified Clostridial toxins and methods of activating recombinantly-expressed Clostridial toxins.
    Type: Application
    Filed: July 15, 2013
    Publication date: October 31, 2013
    Inventors: Marc F. Verhagen, Dean G. Stathakis, Lance E. Steward
  • METHODS OF ACTIVATING CLOSTRIDIAL TOXINS
    Publication number: 20130281666
    Abstract: The specification discloses modified Clostridial toxins comprising an exogenous Clostridial toxin di-chain loop protease cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified Clostridial toxins; method of producing such modified Clostridial toxins, method of activating such modified Clostridial toxins and methods of activating recombinantly-expressed Clostridial toxins.
    Type: Application
    Filed: April 30, 2013
    Publication date: October 24, 2013
    Inventors: Marc F. Verhagen, Dean G. Stathakis, Lance E. Steward
  • METHODS OF ACTIVATING CLOSTRIDIAL TOXINS
    Publication number: 20130245227
    Abstract: The specification discloses modified Clostridial toxins comprising an exogenous Clostridial toxin di-chain loop protease cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified Clostridial toxins; method of producing such modified Clostridial toxins, method of activating such modified Clostridial toxins and methods of activating recombinantly-expressed Clostridial toxins.
    Type: Application
    Filed: May 31, 2013
    Publication date: September 19, 2013
    Applicant: Allergan, Inc.
    Inventors: Marc F. Verhagen, Dean G. Stathakis, Lance E. Steward
  • METHODS OF TREATING CANCER USING OPIOD RETARGETED ENDOPEPIDASES
    Publication number: 20130230502
    Abstract: The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating cancer in a mammal using such TVEMP compositions.
    Type: Application
    Filed: November 20, 2012
    Publication date: September 5, 2013
    Applicant: ALLERGAN, INC.
    Inventors: Birgitte P.S. Jacky, Patton E. Garay, Yanira Molina, Dean G. Stathakis, Joseph Francis, Kei Roger Aoki, Ester Fernandez-Salas
  • Methods of Treating Cancer Using Growth Factor Retargeted Endopeptidases
    Publication number: 20130195838
    Abstract: The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating cancer in a mammal using such TVEMP compositions.
    Type: Application
    Filed: August 9, 2012
    Publication date: August 1, 2013
    Applicant: ALLERGAN, INC.
    Inventors: Birgitte P.S. JACKY, Patton E. Garay, Yanira Molina, Dean G. Stathakis, Joseph Francis, Kei Roger Aoki, Ester Fernandez-Salas, Lance E. Steward, Sanjiv Ghanshani, Terrence J. Hunt
  • Methods of activating clostridial toxins
    Patent number: 8486422
    Abstract: The specification discloses modified Clostridial toxins comprising an exogenous Clostridial toxin di-chain loop protease cleavage site located within the di-chain loop region; polynucleotide molecules encoding such modified Clostridial toxins; method of producing such modified Clostridial toxins, method of activating such modified Clostridial toxins and methods of activating recombinantly-expressed Clostridial toxins.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: July 16, 2013
    Inventors: Marc F. Verhagen, Dean G. Stathakis, Lance E. Steward
  • Methods of treating urogenital-neurological disorders using galanin retargeted endopepidases
    Patent number: 8198229
    Abstract: The present specification discloses TVEMPs, compositions comprising such toxins and methods of treating urogenital-neurological disorders in a mammal using such TVEMPs and compositions.
    Type: Grant
    Filed: May 17, 2010
    Date of Patent: June 12, 2012
    Assignee: Allergan, Inc.
    Inventors: Joseph Francis, Dean G. Stathakis
  • Methods of Treating Cancer Using Tachykinin Retargeted Endopepidases
    Publication number: 20110110911
    Abstract: The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating cancer in a mammal using such TVEMP compositions.
    Type: Application
    Filed: August 16, 2010
    Publication date: May 12, 2011
    Inventors: Birgitte P.S. Jacky, Patton E. Garay, Yanira Molina, Dean G. Stathakis, Joseph Francis, Kei Roger Aoki, Ester Fernandez-Salas
  • Methods of Treating Cancer Using Galanin Retargeted Endopepidases
    Publication number: 20110070211
    Abstract: The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating cancer in a mammal using such TVEMP compositions.
    Type: Application
    Filed: August 13, 2010
    Publication date: March 24, 2011
    Inventors: BIRGITTE P.S. JACKY, PATTON E. GARAY, YANIRA MOLINA, DEAN G. STATHAKIS, JOSEPH FRANCIS, KEI ROGER AOKI, ESTER FERNANDEZ-SALAS
  • METHODS OF TREATING CANCER USING NEUROTROPHIN RETARGETED ENDOPEPTIDASES
    Publication number: 20110070215
    Abstract: The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating cancer in a mammal using such TVEMP compositions.
    Type: Application
    Filed: August 16, 2010
    Publication date: March 24, 2011
    Inventors: Birgitte P.S. Jacky, Patton E. Garay, Yanira Molina, Dean G. Stathakis, Joseph Francis, Kei Roger Aoki, Ester Fernandez-Salas
  • Methods of Treating Cancer Using Growth Factor Retargeted Endopeptidases
    Publication number: 20110070186
    Abstract: The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating cancer in a mammal using such TVEMP compositions.
    Type: Application
    Filed: August 16, 2010
    Publication date: March 24, 2011
    Inventors: Birgitte P.S. Jacky, Patton E. Garay, Yanira Molina, Dean G. Stathakis, Joseph Francis, Kei Roger Aoki, Ester Fernandez-Salas
  • Methods of Treating Cancer Using Glucagon-Like Hormone Retargeted Endopeptidases
    Publication number: 20110070212
    Abstract: The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating cancer in a mammal using such TVEMP compositions.
    Type: Application
    Filed: August 16, 2010
    Publication date: March 24, 2011
    Inventors: Birgitte P.S. Jacky, Patton E. Garay, Yanira Molina, Dean G. Stathakis, Joseph Francis, Kei Roger Aoki, Ester Fernandez-Salas
  • Methods of Treating Cancer Using Opioid Retargeted Endopepidases
    Publication number: 20110064713
    Abstract: The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating cancer in a mammal using such TVEMP compositions.
    Type: Application
    Filed: August 13, 2010
    Publication date: March 17, 2011
    Inventors: Birgitte P.S. Jacky, Patton E. Garay, Yanira Molina, Dean G. Stathakis, Joseph Francis, Kei Roger Aoki, Ester Fernandez-Salas
  • Methods of Treating Chronic Neurogenic Inflammation Using Glucagon Like Hormone Retargeted Endopepidases
    Publication number: 20100303791
    Abstract: The present specification discloses TVEMPs, compositions comprising such toxins and methods of treating chronic neurogenic inflammation in a mammal using such TVEMPs and compositions.
    Type: Application
    Filed: May 17, 2010
    Publication date: December 2, 2010
    Inventors: JOSEPH FRANCIS, DEAN G. STATHAKIS
  • Methods of Treating Chronic Neurogenic Inflammation Using Interleukin Retargeted Endopepidases
    Publication number: 20100303757
    Abstract: The present specification discloses TVEMPs, compositions comprising such toxins and methods of treating chronic neurogenic inflammation in a mammal using such TVEMPs and compositions.
    Type: Application
    Filed: May 17, 2010
    Publication date: December 2, 2010
    Inventors: JOSEPH FRANCIS, DEAN G. STATHAKIS
  • Methods of Treating Urogenital-Neurological Disorders Using Glucagon Like Hormone Retargeted Endopepidases
    Publication number: 20100303794
    Abstract: The present specification discloses TVEMPs, compositions comprising such toxins and methods of treating urogenital-neurological disorders in a mammal using such TVEMPs and compositions.
    Type: Application
    Filed: May 17, 2010
    Publication date: December 2, 2010
    Inventors: Joseph Francis, Dean G. Stathakis
  • Methods of Treating Urogenital-Neurological Disorders Using Interleukin Retargeted Endopepidases
    Publication number: 20100303756
    Abstract: The present specification discloses TVEMPs, compositions comprising such toxins and methods of treating urogenital-neurological disorders in a mammal using such TVEMPs and compositions.
    Type: Application
    Filed: May 17, 2010
    Publication date: December 2, 2010
    Inventors: Joseph Francis, Dean G. Stathakis
  • Methods of Treating Urogenital-Neurological Disorders Using Galanin Retargeted Endopepidases
    Publication number: 20100303787
    Abstract: The present specification discloses TVEMPs, compositions comprising such toxins and methods of treating urogenital-neurological disorders in a mammal using such TVEMPs and compositions.
    Type: Application
    Filed: May 17, 2010
    Publication date: December 2, 2010
    Inventors: Joseph Francis, Dean G. Stathakis
  • Methods of Treating Urogenital-Neurological Disorders Using Neurotrophin Retargeted Endopepidases
    Publication number: 20100303798
    Abstract: The present specification discloses TVEMPs, compositions comprising such toxins and methods of treating urogenital-neurological disorders in a mammal using such TVEMPs and compositions.
    Type: Application
    Filed: May 17, 2010
    Publication date: December 2, 2010
    Inventors: Joseph Francis, Dean G. Stathakis