Patents by Inventor Dean H. Hamer

Dean H. Hamer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vector encoding hepatitis B surface antigen
    Patent number: 4696898
    Abstract: Recombinant DNA vector including (1) a promoter for a eukaryotic metalliothionein gene ligated to a gene sequence encoding hepatitis B surface antigen, and (2) at least the 69% transforming region of the bovine papilloma genome, expression of the hepatitis B surface antigen encoding gene sequence being under the control of the metallothionein promoter.
    Type: Grant
    Filed: January 16, 1984
    Date of Patent: September 29, 1987
    Assignee: Integrated Genetics, Inc.
    Inventors: Renee A. Fitts, Nancy Hsiung, Dean H. Hamer
  • Protein from SV40 recombinants
    Patent number: 4599308
    Abstract: An E. Coli plasmid SV40 vector recombinant is cloned to a gene of interest and amplified in bacteria. The SV40 vector-gene of interest can be introduced into eukaryotic cells by transformation or transfection and the gene of interest produces its protein product.
    Type: Grant
    Filed: September 29, 1983
    Date of Patent: July 8, 1986
    Inventors: Dean H. Hamer, Marian Kaehler, Philip Leder
  • Simian virus recombinant that directs the synthesis of hepatitis B surface antigen
    Patent number: 4442205
    Abstract: A process for producing a recombinant between simian virus 40 (SV40) and hepatitis B virus (HBV) is given. When tissue culture cells are infected with the recombinant, hepatitis B surface antigen is produced. Because a single cloned gene is used, the surface antigen produced is homogeneous and can be produced without conventional dependence on human sera. The antigen is excreted into the culture medium as 22 nm particles with the same physical properties, antigenic composition and constituent polypeptides as those found in the sera of patients with Type B hepatitis. The antigen is useful for the preparation of vaccines.
    Type: Grant
    Filed: September 22, 1981
    Date of Patent: April 10, 1984
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Dean H. Hamer, John Gerin