Patents by Inventor Dean James Rager-Aguiar

Dean James Rager-Aguiar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230190664
    Abstract: Disclosed are crosslinked particles (e.g., microparticles) that are capable of storing and releasing drugs. The particles can be macroparticles, microparticles, or nanoparticles and can be composed of polyester backbones. The particles can be loaded with a drug. The particles can degrade in vivo to release the drug. The particles can be prepared by crosslinking functionalized polyester backbones and loaded with a given drug. The particles of the present disclosure can be injected with a syringe. In some embodiments, the particles of the present disclosure are administered in connection with a surgery and release the drug after the site of the surgery for a period of 1-6 months.
    Type: Application
    Filed: July 22, 2022
    Publication date: June 22, 2023
    Inventors: Frantz LE DEVEDEC, Christine ALLEN, David M. STEVENS, Dean James RAGER-AGUIAR, Timothy Tordella RUCKH, Carl Eric ELMQUIST
  • Patent number: 11426356
    Abstract: Disclosed are crosslinked particles (e.g., microparticles) that are capable of storing and releasing drugs. The particles can be macroparticles, microparticles, or nanoparticles and can be composed of polyester backbones. The particles can be loaded with a drug. The particles can degrade in vivo to release the drug. The particles can be prepared by crosslinking functionalized polyester backbones and loaded with a given drug. The particles of the present disclosure can be injected with a syringe. In some embodiments, the particles of the present disclosure are administered in connection with a surgery and release the drug after the site of the surgery for a period of 1-6 months.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: August 30, 2022
    Assignees: Pendant Biosciences, Inc., The Governing Council of the University of Toronto
    Inventors: Frantz Le Devedec, Christine Allen, David M. Stevens, Dean James Rager-Aguiar, Timothy Tordella Ruckh, Carl Eric Elmquist
  • Patent number: 11235030
    Abstract: Provided herein are compositions and methods for the treatment of tendinopathies, such as tenosynovitis, tendinosis or tendinitis, including Achilles tendinopathy, patellar tendinopathy, lateral epicondylitis or “tennis elbow,” medial epicondylitis or “golfer's elbow,” plantar fasciitis, and rotator cuff tendinopathy, and in particular to methods for the treatment of tendinopathies by administering compositions comprising platelet-derived growth factor (PDGF).
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: February 1, 2022
    Assignee: BioMimetic Therapeutics, LLC
    Inventors: Hans K. Kestler, Vivek Shah, Dean James Rager-Aguiar
  • Publication number: 20200222504
    Abstract: Provided herein are compositions and methods for the treatment of tendinopathies, such as tenosynovitis, tendinosis or tendinitis, including Achilles tendinopathy, patellar tendinopathy, lateral epicondylitis or “tennis elbow,” medial epicondylitis or “golfer's elbow,” plantar fasciitis, and rotator cuff tendinopathy, and in particular to methods for the treatment of tendinopathies by administering compositions comprising platelet-derived growth factor (PDGF).
    Type: Application
    Filed: October 15, 2019
    Publication date: July 16, 2020
    Inventors: Hans K. Kestler, Vivek Shah, Dean James Rager-Aguiar
  • Patent number: 10493130
    Abstract: Provided herein are compositions and methods for the treatment of tendinopathies, such as tenosynovitis, tendinosis or tendinitis, including Achilles tendinopathy, patellar tendinopathy, lateral epicondylitis or “tennis elbow,” medial epicondylitis or “golfer's elbow,” plantar fasciitis, and rotator cuff tendinopathy, and in particular to methods for the treatment of tendinopathies by administering compositions comprising platelet-derived growth factor (PDGF).
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: December 3, 2019
    Assignee: BIOMIMETIC THERAPEUTICS, LLC
    Inventors: Hans K. Kestler, Vivek Shah, Dean James Rager-Aguiar
  • Publication number: 20190262274
    Abstract: Disclosed are crosslinked particles (e.g., microparticles) that are capable of storing and releasing drugs. The particles can be macroparticles, microparticles, or nanoparticles and can be composed of polyester backbones. The particles can be loaded with a drug. The particles can degrade in vivo to release the drug. The particles can be prepared by crosslinking functionalized polyester backbones and loaded with a given drug. The particles of the present disclosure can be injected with a syringe. In some embodiments, the particles of the present disclosure are administered in connection with a surgery and release the drug after the site of the surgery for a period of 1-6 months.
    Type: Application
    Filed: February 27, 2019
    Publication date: August 29, 2019
    Inventors: Frantz Le Devedec, Christine Allen, David M. Stevens, Dean James Rager-Aguiar, Timothy Tordella Ruckh, Carl Eric Elmquist
  • Patent number: 10258578
    Abstract: Disclosed are crosslinked particles (e.g., microparticles) that are capable of storing and releasing drugs. The particles can be macroparticles, microparticles, or nanoparticles and can be composed of polyester backbones. The particles can be loaded with a drug. The particles can degrade in vivo to release the drug. The particles can be prepared by crosslinking functionalized polyester backbones and loaded with a given drug. The particles of the present disclosure can be injected with a syringe. In some embodiments, the particles of the present disclosure are administered in connection with a surgery and release the drug after the site of the surgery for a period of 1-6 months.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: April 16, 2019
    Assignee: PENDANT BIOSCIENCES, INC.
    Inventors: Frantz Le Dévédec, Christine Jane Allen, David M. Stevens, Dean James Rager-Aguiar, Timothy Tordella Ruckh, Carl Eric Elmquist
  • Publication number: 20180085433
    Abstract: Provided herein are compositions and methods for the treatment of tendinopathies, such as tenosynovitis, tendinosis or tendinitis, including Achilles tendinopathy, patellar tendinopathy, lateral epicondylitis or “tennis elbow,” medial epicondylitis or “golfer's elbow,” plantar fasciitis, and rotator cuff tendinopathy, and in particular to methods for the treatment of tendinopathies by administering compositions comprising platelet-derived growth factor (PDGF).
    Type: Application
    Filed: March 31, 2017
    Publication date: March 29, 2018
    Inventors: Hans K. Kestler, Vivek Shah, Dean James Rager-Aguiar
  • Patent number: 9642892
    Abstract: Provided herein are compositions and methods for the treatment of tendinopathies, such as tenosynovitis, tendinosis or tendinitis, including Achilles tendinopathy, patellar tendinopathy, lateral epicondylitis or “tennis elbow,” medial epicondylitis or “golfer's elbow,” plantar fasciitis, and rotator cuff tendinopathy, and in particular to methods for the treatment of tendinopathies by administering compositions comprising platelet-derived growth factor (PDGF).
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: May 9, 2017
    Assignee: BioMimetic Therapeutics, LLC
    Inventors: Hans K. Kestler, Vivek Shah, Dean James Rager-Aguiar
  • Publication number: 20170100343
    Abstract: Disclosed are crosslinked particles (e.g., microparticles) that are capable of storing and releasing drugs. The particles can be macroparticles, microparticles, or nanoparticles and can be composed of polyester backbones. The particles can be loaded with a drug. The particles can degrade in vivo to release the drug. The particles can be prepared by crosslinking functionalized polyester backbones and loaded with a given drug. The particles of the present disclosure can be injected with a syringe. In some embodiments, the particles of the present disclosure are administered in connection with a surgery and release the drug after the site of the surgery for a period of 1-6 months.
    Type: Application
    Filed: October 7, 2016
    Publication date: April 13, 2017
    Inventors: Frantz Le Dévédec, Christine Jane Allen, David Michael Stevens, Dean James Rager-Aguiar, Timothy Tordella Ruckh, Carl Eric Elmquist
  • Publication number: 20160184482
    Abstract: The invention provides compositions and methods for treatment of tendon and ligament injuries and/or repair of damaged tendons and ligament. The invention provides compositions comprising a biocompatible matrix and platelet-derived growth factor (PDGF).
    Type: Application
    Filed: September 29, 2014
    Publication date: June 30, 2016
    Inventors: Samuel E. Lynch, Leslie Wisner-Lynch, Hans K. Kestler, Yanchun Liu, Christopher Hee, Joshua Nickols, Dean James Rager-Aguiar
  • Publication number: 20140005110
    Abstract: Provided herein are compositions and methods for the treatment of tendinopathies, such as tenosynovitis, tendinosis or tendinitis, including Achilles tendinopathy, patellar tendinopathy, lateral epicondylitis or “tennis elbow,” medial epicondylitis or “golfer's elbow,” plantar fasciitis, and rotator cuff tendinopathy, and in particular to methods for the treatment of tendinopathies by administering compositions comprising platelet-derived growth factor (PDGF).
    Type: Application
    Filed: June 21, 2013
    Publication date: January 2, 2014
    Applicant: BioMimetic Therapeutics, LLC
    Inventors: Hans K. Kestler, Vivek Shah, Dean James Rager-Aguiar
  • Patent number: 8492335
    Abstract: Provided herein are compositions and methods for the treatment of tendinopathies, such as tenosynovitis, tendinosis or tendinitis, including Achilles tendinopathy, patellar tendinopathy, lateral epicondylitis or “tennis elbow,” medial epicondylitis or “golfer's elbow,” plantar fasciitis, and rotator cuff tendinopathy, and in particular to methods for the treatment of tendinopathies by administering compositions comprising platelet-derived growth factor (PDGF).
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: July 23, 2013
    Assignee: BioMimetic Therapeutics, LLC
    Inventors: Hans K. Kestler, Vivek Shah, Dean James Rager-Aguiar
  • Publication number: 20110245170
    Abstract: Provided herein are compositions and methods for the treatment of tendinopathies, such as tenosynovitis, tendinosis or tendinitis, including Achilles tendinopathy, patellar tendinopathy, lateral epicondylitis or “tennis elbow,” medial epicondylitis or “golfer's elbow,” plantar fasciitis, and rotator cuff tendinopathy, and in particular to methods for the treatment of tendinopathies by administering compositions comprising platelet-derived growth factor (PDGF).
    Type: Application
    Filed: February 22, 2011
    Publication date: October 6, 2011
    Inventors: Hans K. KESTLER, Vivek Shah, Dean James Rager-Aguiar