Abstract: The present invention relates to pharmaceutical dosage forms suitable for gastrointestinal delivery, as well as to methods for the treatment of conditions suitable for treatment by gastrointestinal delivery.

Abstract: The present disclosure relates to CAR-T cells and uses thereof. Disclosed herein is a genetically modified T cell comprising a nucleic acid sequence encoding a chimeric antigen receptor (CAR) polypeptide comprising a single-chain variable fragment (scFV) that specifically binds to a target molecule, wherein the nucleic acid sequence encoding the CAR polypeptide is integrated into an integration site located at a miR-155 host gene.

Abstract: A method, system and non-transitory computer-readable medium used for testing a plurality of circuits to determine open surfaces are disclosed. The method includes: receiving one or more of attack techniques, and known open surfaces; carrying out attacks on a circuit to determine vulnerable surfaces of the circuit; determining when new open surfaces exist in the circuit; updating an attack plan based on the new open surfaces; carrying out the attack plan; generating a report of the open and vulnerable surfaces; and updating a repository to include new attack techniques against newly discovered open surfaces of the circuit.

Abstract: Described herein are compositions comprising universal donor natural killer (NK) cells, populations of such cells, methods of obtaining and preparing such cells, and methods of use of such cells and compositions in medical treatment of cancers and infectious disease.

Abstract: A method, system and non-transitory computer-readable medium used for testing a plurality of circuits to determine open surfaces are disclosed. The method includes: receiving one or more of attack techniques, and known open surfaces; carrying out attacks on a circuit to determine vulnerable surfaces of the circuit; determining when new open surfaces exist in the circuit; updating an attack plan based on the new open surfaces; carrying out the attack plan; generating a report of the open and vulnerable surfaces; and updating a repository to include new attack techniques against newly discovered open surfaces of the circuit.

Abstract: A hot melt adhesive (HMA) composition includes (A) from 1-60 wt % of a block composite compatibilizer comprising (i) a hard polymer that includes propylene, (ii) a soft polymer that includes ethylene, and (iii) a block copolymer having a soft block and a hard block, the hard block of the block copolymer having the same composition as the hard polymer of the block composite compatibilizer and the soft block of the block copolymer having the same composition as the soft polymer of the block composite compatibilizer; (B) from 1-70 wt % of a tackifier; (C) from 1-40 wt % of at least one selected from the group of a wax and an oil; and (D) Optionally, from greater than zero to 97 wt % of a polymer component that includes an ethylene-based polymer and/or a propylene-based polymer.

Abstract: A composition includes (A) 30-95 wt % of a random or homogeneous propylene-based interpolymer having: (i) a comonomer content of at least one of C2 and C4-10 ?-olefins of 7 wt % to 49 wt % based on the total weight of the propylene-based interpolymer, (ii) a density of 0.90 g/cc or less, and (iii) an MFR of 1 g/10 min or greater (230° C./2.16 kg); and (B) 5-70 wt % of a block composite nucleator comprising: (1) a first polymer that includes polypropylene; (2) a second polymer that includes an alpha-olefin based polymer, the alpha-olefin being selected from at least one of a C2 and C4-10 ?-olefins, and (3) a block copolymer having a first segment and a second segment, the first segment of the block copolymer having the same composition as the first polymer in the block composite nucleator and the second segment of the block copolymer having the same composition as the second polymer of the block composite nucleator.

Abstract: A composition includes (A) 30-95 wt % of a random or homogeneous propylene-based interpolymer having: (i) a comonomer content of at least one of C2 and C4-10 ?-olefins of 7 wt % to 49 wt % based on the total weight of the propylene-based interpolymer, (ii) a density of 0.90 g/cc or less, and (iii) an MFR of 1 g/10 min or greater (230° C./2.16 kg); and (B) 5-70 wt % of a block composite nucleator comprising: (1) a first polymer that includes polypropylene; (2) a second polymer that includes an alpha-olefin based polymer, the alpha-olefin being selected from at least one of a C2 and C4-10 ?-olefins, and (3) a block copolymer having a first segment and a second segment, the first segment of the block copolymer having the same composition as the first polymer in the block composite nucleator and the second segment of the block copolymer having the same composition as the second polymer of the block composite nucleator.

Abstract: A hot melt adhesive (HMA) composition includes (A) from 1-60 wt % of a block composite compatibilizer comprising (i) a hard polymer that includes propylene, (ii) a soft polymer that includes ethylene, and (iii) a block copolymer having a soft block and a hard block, the hard block of the block copolymer having the same composition as the hard polymer of the block composite compatibilizer and the soft block of the block copolymer having the same composition as the soft polymer of the block composite compatibilizer; (B) from 1-70 wt % of a tackifier; (C) from 1-40 wt % of at least one selected from the group of a wax and an oil; and (D) Optionally, from greater than zero to 97 wt % of a polymer component that includes an ethylene-based polymer and/or a propylene-based polymer.

Abstract: There is disclosed a system and method for implementing concurrent ingress and egress viewing of network traffic data to evaluate the performance of a device under test. The method may be performed by a network testing system. The method may be performed in real-time.

Abstract: There is disclosed a system and method for implementing a control plane/data plane test to evaluate the performance of a device under test upon the occurrence of a critical event. The method may be performed by a network testing system.

Abstract: There is disclosed a system and method for implementing concurrent ingress and egress viewing of network traffic data to evaluate the performance of a device under test. The method may be performed by a network testing system. The method may be performed in real-time.

Abstract: There is disclosed a system and method for implementing concurrent real-time ingress and egress viewing of network traffic data to evaluate the performance of a device under test. The method may be performed by a network testing system.

Abstract: A borehole network including first and second end surface locations and at least one intermediate surface location interconnected by a subterranean path, and a method for connecting a subterranean path between a first borehole including a directional section and a second borehole including a directional section. A directional drilling component is drilled in at least one of the directional sections to obtain a required proximity between the first and second boreholes. An intersecting component is drilled, utilizing magnetic ranging techniques, from one directional section to provide a borehole intersection between the first and second boreholes, thereby connecting the subterranean path.

Abstract: A borehole network including first and second end surface locations and at least one intermediate surface location interconnected by a subterranean path, and a method for connecting a subterranean path between a first borehole including a directional section and a second borehole including a directional section. A directional drilling component is drilled in at least one of the directional sections to obtain a required proximity between the first and second boreholes. An intersecting component is drilled, utilizing magnetic ranging techniques, from one directional section to provide a borehole intersection between the first and second boreholes, thereby connecting the subterranean path.

Abstract: A borehole network including first and second end surface locations and at least one intermediate surface location interconnected by a subterranean path, and a method for connecting a subterranean path between a first borehole including a directional section and a second borehole including a directional section. A directional drilling component is drilled in at least one of the directional sections to obtain a required proximity between the first and second boreholes. An intersecting component is drilled, utilizing magnetic ranging techniques, from one directional section to provide a borehole intersection between the first and second boreholes, thereby connecting the subterranean path.

Abstract: A borehole network including first and second end surface locations and at least one intermediate surface location interconnected by a subterranean path, and a method for connecting a subterranean path between a first borehole including a directional section and a second borehole including a directional section. A directional drilling component is drilled in at least one of the directional sections to obtain a required proximity between the first and second boreholes. An intersecting component is drilled, utilizing magnetic ranging techniques, from one directional section to provide a borehole intersection between the first and second boreholes, thereby connecting the subterranean path.

Abstract: There is disclosed a system and method for implementing concurrent real-time ingress and egress viewing of network traffic data to evaluate the performance of a device under test. The method may be performed by a network testing system.

Abstract: There is disclosed a system and method for implementing a control plane/data plane test to evaluate the performance of a device under test upon the occurrence of a critical event. The method may be performed by a network testing system.

Abstract: A borehole network including first and second end surface locations and at least one intermediate surface location interconnected by a subterranean path, and a method for connecting a subterranean path between a first borehole including a directional section and a second borehole including a directional section. A directional drilling component is drilled in at least one of the directional sections to obtain a required proximity between the first and second boreholes. An intersecting component is drilled, utilizing magnetic ranging techniques, from one directional section to provide a borehole intersection between the first and second boreholes, thereby connecting the subterranean path.