Patents by Inventor Dean R. Bender

Dean R. Bender has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing certain aza cyclohexapeptides
    Patent number: 5552521
    Abstract: There is disclosed a novel process for preparing aza cyclohexapeptides of the formula ##STR1## where all variables are defined herein.
    Type: Grant
    Filed: February 10, 1995
    Date of Patent: September 3, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Kevin M. Belyk, Dean R. Bender, Regina M. Black, David L. Hughes, William Leonard
  • Process for producing 1-beta-methylcarbapenem antibiotic intermediates
    Patent number: 4816577
    Abstract: A process for isomerizing an alpha methylated azetidinone alkyl ester to the corresponding beta-methyl isomer, which is an intermediate in the synthesis of 1-beta-methylcarbapenem antibacterial agents. The process involves treating the dianion of structure I, being the alpha isomer, with a P-H or S-H containing organic protic acid, organometallic Sn or Pb hydride, metallic cation salt or trialkyl borane, followed by quenching with an OH protic organic acid or mineral acid.
    Type: Grant
    Filed: December 16, 1987
    Date of Patent: March 28, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Dean R. Bender, Ichiro Shinkai, Anthony M. De Marco, James A. McCauley
  • Process for 5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine
    Patent number: 4477668
    Abstract: (+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine, and its pharmaceutically acceptable salts is useful as an anxiolytic, antidepressant, anticonvulsant, muscle relaxant and in the treatment of mixed anxiety-depression, minimal brain dysfunction and extrapyramidal disorders such as Parkinson's disease. The racemate of the compound is produced by a four-step synthetic process in about 65% yield from 5H-dibenzo[a,d]cyclohepten-5-one.
    Type: Grant
    Filed: September 3, 1982
    Date of Patent: October 16, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Dean R. Bender, Sandor Karady, Theresa Rothauser
  • Coumarin derivatives and method for synthesizing 5'-methyl psoralens therefrom
    Patent number: 4398031
    Abstract: Two species of a coumarin derivative are disclosed, both of which may be produced from a 7-hydroxycoumarin precursor. The one species is an oxime and the other is a .beta.-haloallyl ester.A method for making a psoralen compound in high yield comprises treating these coumarin derivatives with an acid to fuse a furan ring thereto, and recovering a 5'-methyl psoralen therefrom. The 5'-methyl psoralen may be produced in up to about 70% overall yield with respect to the 7-hydroxycoumarin precursor.
    Type: Grant
    Filed: March 9, 1982
    Date of Patent: August 9, 1983
    Assignee: The Regents of the University of California
    Inventors: Dean R. Bender, John E. Hearst, Henry Rapoport