Patents by Inventor Dean R. DRAGOLI

Dean R. DRAGOLI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTAGONISTS OF CHEMOKINE RECEPTORS
    Publication number: 20180369213
    Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
    Type: Application
    Filed: February 20, 2018
    Publication date: December 27, 2018
    Inventors: Xi CHEN, Dean R. DRAGOLI, Pingchen FAN, Yandong LI, Jay P. POWERS, Sreenivas PUNNA, Hiroko TANAKA, Penglie ZHANG
  • CCR6 compounds
    Patent number: 10117865
    Abstract: Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: November 6, 2018
    Assignee: ChemoCentryx, Inc.
    Inventors: Daniel Dairaghi, Dean R. Dragoli, Jaroslaw Kalisiak, Christopher W. Lange, Manmohan Reddy Leleti, Yandong Li, Rebecca M. Lui, Venkat Reddy Mali, Viengkham Malathong, Jay P. Powers, Hiroko Tanaka, Joanne Tan, Matthew J. Walters, Ju Yang, Penglie Zhang
  • INHIBITORS OF CXCR2
    Publication number: 20180170916
    Abstract: Compounds are provided as inhibitors of CXCR2, having the structure:
    Type: Application
    Filed: October 2, 2017
    Publication date: June 21, 2018
    Inventors: Xi CHEN, Dean R. DRAGOLI, Junfa FAN, Jaroslaw KALISIAK, Manmohan Reddy LELETI, Viengkham MALATHONG, Jeffrey McMAHON, Hiroko TANAKA, Ju YANG, Chao YU, Penglie ZHANG, Venkat MALI
  • MODULATORS OF CHEMOKINE RECEPTORS
    Publication number: 20180141934
    Abstract: Compounds are provided as chemokine inhibitors having the structure:
    Type: Application
    Filed: October 26, 2017
    Publication date: May 24, 2018
    Inventors: Xi CHEN, Dean R. DRAGOLI, Junfa FAN, Jaroslaw KALISIAK, Antoni KRASINSKI, Manmohan Reddy LELETI, Venkat MALI, Jeffrey McMAHON, Rajinder SINGH, Hiroko TANAKA, Ju YANG, Chao YU, Penglie ZHANG
  • CCR6 COMPOUNDS
    Publication number: 20180092902
    Abstract: Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
    Type: Application
    Filed: September 19, 2017
    Publication date: April 5, 2018
    Inventors: Daniel DAIRAGHI, Dean R. DRAGOLI, Jaroslaw KALISIAK, Christopher W. LANGE, Manmohan Reddy LELETI, Yandong LI, Rebecca M. LUI, Venkat Reddy MALI, Viengkham MALATHONG, Jay P. POWERS, Hiroko TANAKA, Joanne TAN, Matthew J. WALTERS, Ju YANG, Penglie ZHANG
  • DIAZOLE AMIDES
    Publication number: 20180071257
    Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.
    Type: Application
    Filed: July 25, 2017
    Publication date: March 15, 2018
    Inventors: Xi CHEN, Dean R. DRAGOLI, Pingchen FAN, Juan C. JAEN, Yandong LI, Jay P. POWERS, Viengkham MALATHONG, Sreenivas PUNNA, Hiroko TANAKA, Penglie ZHANG
  • Modulators of chemokine receptors
    Patent number: 9834545
    Abstract: Compounds are provided as chemokine inhibitors having the structure:
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: December 5, 2017
    Assignee: CHEMOCENTRYX, INC.
    Inventors: Xi Chen, Dean R. Dragoli, Junfa Fan, Jaroslaw Kalisiak, Antoni Krasinski, Manmohan Reddy Leleti, Venkat Mali, Jeffrey McMahon, Rajinder Singh, Hiroko Tanaka, Ju Yang, Chao Yu, Penglie Zhang
  • Inhibitors of CXCR2
    Patent number: 9809581
    Abstract: Compounds are provided as inhibitors of CXCR2, having the structure:
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: November 7, 2017
    Assignee: ChemoCentryx, Inc.
    Inventors: Xi Chen, Dean R. Dragoli, Junfa Fan, Jaroslaw Kalisiak, Manmohan Reddy Leleti, Viengkham Malathong, Jeffrey McMahon, Hiroko Tanaka, Ju Yang, Chao Yu, Penglie Zhang, Venkat Mali
  • CCR6 compounds
    Patent number: 9795599
    Abstract: Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: October 24, 2017
    Assignee: CHEMOCENTRYX, INC.
    Inventors: Daniel Dairaghi, Dean R. Dragoli, Jaroslaw Kalisiak, Christopher W. Lange, Manmohan Reddy Leleti, Yandong Li, Rebecca M. Lui, Venkat Reddy Mali, Viengkham Malathong, Jay P. Powers, Hiroko Tanaka, Joanne Tan, Matthew J. Walters, Ju Yang, Penglie Zhang
  • Diazole amides
    Patent number: 9750722
    Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: September 5, 2017
    Assignee: CHEMOCENTRYX, INC.
    Inventors: Xi Chen, Dean R. Dragoli, Pingchen Fan, Juan C. Jaen, Yandong Li, Jay P. Powers, Viengkham Malathong, Sreenivas Punna, Hiroko Tanaka, Penglie Zhang
  • 2-OXINDOLE COMPOUNDS
    Publication number: 20170204087
    Abstract: Oxindole compounds useful for the treatment of CCR(9) mediated conditions or diseases are provided.
    Type: Application
    Filed: January 18, 2017
    Publication date: July 20, 2017
    Inventors: Xi CHEN, Dean R. DRAGOLI, Pingchen FAN, Manmohan Reddy LELETI, Rebecca M. LUI, Viengkham MALATHONG, Jay P. POWERS, Rajinder SINGH, Hiroko TANAKA, Ju YANG, Chao YU, Penglie ZHANG
  • INHIBITORS OF CXCR2
    Publication number: 20170144996
    Abstract: Compounds are provided as inhibitors of CXCR2, having the structure:
    Type: Application
    Filed: November 17, 2016
    Publication date: May 25, 2017
    Inventors: Xi CHEN, Dean R. DRAGOLI, Junfa FAN, Jaroslaw KALISIAK, Manmohan Reddy LELETI, Viengkham MALATHONG, Jeffrey McMahon, Hiroko TANAKA, Ju YANG, Chao YU, Penglie ZHANG, Venkat Mali
  • MODULATORS OF CHEMOKINE RECEPTORS
    Publication number: 20170144997
    Abstract: Compounds are provided as chemokine inhibitors having the structure:
    Type: Application
    Filed: November 17, 2016
    Publication date: May 25, 2017
    Inventors: Xi CHEN, Dean R. DRAGOLI, Junfa FAN, Jaroslaw KALISIAK, Antoni KRASINSKI, Manmohan Reddy Leleti, Venkat MALI, Jeffrey McMAHON, Rajinder SINGH, Hiroko TANAKA, Ju YANG, Chao YU, Penglie ZHANG
  • CCR6 COMPUNDS
    Publication number: 20160296508
    Abstract: Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
    Type: Application
    Filed: March 18, 2016
    Publication date: October 13, 2016
    Inventors: Daniel Dairaghi, Dean R. Dragoli, Jarek Kalisiak, Christopher W. Lange, Manmohan Reddy Leleti, Yandong Li, Rebecca M. Lui, Venkat Reddy Mali, Viengkham Malathong, Jay P. Powers, Hiroko Tanaka, Joanne Tan, Matthew J. Walters, Ju Yang, Penglie Zhang
  • ANTAGONISTS OF CHEMOKINE RECEPTORS
    Publication number: 20160193191
    Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
    Type: Application
    Filed: October 8, 2015
    Publication date: July 7, 2016
    Inventors: Xi CHEN, Dean R. DRAGOLI, Pingchen FAN, Yandong LI, Jay P. POWERS, Sreenivas PUNNA, Hiroko TANAKA, Penglie ZHANG
  • DIAZOLE AMIDES
    Publication number: 20160193185
    Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.
    Type: Application
    Filed: October 8, 2015
    Publication date: July 7, 2016
    Inventors: Xi CHEN, Dean R. DRAGOLI, Pingchen FAN, Juan C. JAEN, Yandong LI, Jay P. POWERS, Viengkham MALATHONG, Sreenivas PUNNA, Hiroko TANAKA, Penglie ZHANG
  • CCR6 compounds
    Patent number: 9340509
    Abstract: Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
    Type: Grant
    Filed: December 2, 2014
    Date of Patent: May 17, 2016
    Assignee: ChemoCentryx, Inc.
    Inventors: Daniel Dairaghi, Dean R. Dragoli, Jarek Kalisiak, Christopher W. Lange, Manmohan Reddy Leleti, Yandong Li, Rebecca M. Lui, Venkat Reddy Mali, Viengkham Malathong, Jay P. Powers, Hiroko Tanaka, Joanne Tan, Matthew J. Walters, Ju Yang, Penglie Zhang
  • Antagonists of chemokine receptors
    Patent number: 9181241
    Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: November 10, 2015
    Assignee: ChemoCentryx, Inc.
    Inventors: Xi Chen, Dean R. Dragoli, Pingchen Fan, Yandong Li, Jay P. Powers, Sreenivas Punna, Hiroko Tanaka, Penglie Zhang
  • Diazole amides
    Patent number: 9169248
    Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: October 27, 2015
    Assignee: ChemoCentryx, Inc.
    Inventors: Xi Chen, Dean R. Dragoli, Pingchen Fan, Juan C. Jaen, Yandong Li, Jay P. Powers, Viengkham Malathong, Sreenivas Punna, Hiroko Tanaka, Penglie Zhang
  • CCR6 COMPOUNDS
    Publication number: 20150175547
    Abstract: Compounds of formula (I) are provided which are useful in the treatment of diseases or conditions modulated at least in part by CCR6:
    Type: Application
    Filed: December 2, 2014
    Publication date: June 25, 2015
    Inventors: Daniel Dairaghi, Dean R. Dragoli, Jarek Kalisiak, Christopher W. Lange, Manmohan Reddy Leleti, Yandong Li, Rebecca M. Lui, Venkat Reddy Mali, Viengkham Malathong, Jay P. Powers, Hiroko Tanaka, Joanne Tan, Matthew J. Walters, Ju Yang, Penglie Zhang