Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A method for shaping a composite material, the method comprising positioning a composite system in a press tool, the press tool comprising a male mold and a corresponding female mold separated by a gap, wherein the male mold and the female mold each independently have a non-planar molding surface, compressing the composite system between the male mold and the female mold by closing the gap between the male mold and the female mold; and maintaining the male mold and the female mold in a closed position until the viscosity of the composite system reaches a level sufficient to maintain a molded shape.

Abstract: Disclosed is a method and apparatus for utilizing a variable gain algorithm for adjusting a capacitor in an automatic radio frequency (RF) impedance matching network. The apparatus may operate in a closed-loop feedback control system, with one or more error signals driving the capacitors within the system. To achieve a critically damped control system response, multiple operating regions for the matching network and its constituent elements may be identified and a set of gains (e.g., different per region) may be applied to the error signals in the control system when operating in those regions. An operating region may be defined by characteristics of the input signals measured by the apparatus, calculated by the apparatus, or the state of the apparatus itself. These features may be arranged in a look up table (or determined by calculation) for the apparatus to use to determine the variable gains in the system.

Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The present invention relates to compounds that inhibit KRas G12D, In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.

Abstract: Control systems and methods for coordinating multiple agricultural machines for operation on an agricultural field are provided. Each machine may receive field data for an agricultural field that optionally includes a plurality of pre-defined swaths. Each machine may receive state data from other machine(s). The state data for the other machine(s) may include a next swath and a current swath. Each machine may, after an indication of a start of its current swath, determine a next swath based on open swaths and the state data for the other machine(s). A next swath may also be determined using vehicle kinematic data, and conflicts between machines may be resolved.

Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: Compounds that inhibit KRas G12D; in particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Provided herein is a compound of the Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7 and L are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors.

Abstract: Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.

Abstract: Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.

Abstract: Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.

Abstract: The disclosure provides a work tool positioning system for a work machine comprising a movable work tool. The work tool positioning system comprises a work tool mounted at an end of a movable arm. At least one proximity sensor is provided for providing a proximity signal indicative of a distance between the at least one proximity sensor and an object in front of the proximity sensor. A processor is configured to receive the proximity signal and to calculate a clearance distance between a reference location on the work tool and an object in front of the proximity sensor. An alert system is provided for alerting an operator of the work machine. The processor is configured to activate one or more alerts when the clearance distance is greater than or equal to a first threshold unloading distance.

Abstract: Slide bearing plates and related methods of use. A slide bearing plate has a body; a pipe shoe slide channel defined in a top face of the body; in which opposed walls and a base of the pipe shoe slide channel are made of a bearing material. A slide bearing plate has a body; a pipe shoe slide channel defined in a top face of the body; and a beam slide channel defined in a base face of the body. A slide bearing plate has: a body formed of a bearing material; and one or more of: a pipe shoe receptacle defined by a top face of the body; or a beam receptacle defined by a base face of the body. A pipe support stand has: a pipe; a pipe shoe supporting the pipe; a slide bearing plate supporting a base of the pipe shoe within the pipe shoe slide channel. A method involves installing a slide bearing plate between a pipe shoe and a support beam.

Abstract: A touch-based computer graphics user interface enhances a stylus pen with virtual suction to create a virtual vacuum or suction tool. The virtual tool may simulate a physical world suction tool and/or provide capabilities not available in the real world. The virtual suction tool allows the user to feel as if he or she has transcended the boundary between the virtual world and the real world by physically holding in his or her hand an object that is able to interact with and virtually attract and contain items (e.g., objects with characteristics and behaviors) removed from or expellable into the virtual world. The resulting highly intuitive user interface provides fun and exciting video game play and has other applications as well.

Abstract: An apparatus comprising: a frame; a shaft mounted to the frame for rotation; plural vanes each mounted for rotation about a respective pitch adjustment axis on one or more respective arms extending from the shaft; a collar mounted to the frame coaxial with the shaft, the collar having a first outer circumferential surface defining a convex cam shape, and a second outer circumferential surface defining a non cam circular shape; and plural followers arranged to contact the first outer circumferential surface in a first configuration corresponding to a first speed of rotation of the shaft and the second outer circumferential surface in a second configuration corresponding to a second speed of rotation of the shaft, the second speed being higher than the first speed, the plural followers being each connected to adjust the pitch of a respective vane of the plural vanes.

Abstract: A touch-based computer graphics user interface enhances a stylus pen with virtual suction to create a virtual vacuum or suction tool. The virtual tool may simulate a physical world suction tool and/or provide capabilities not available in the real world. The virtual suction tool allows the user to feel as if he or she has transcended the boundary between the virtual world and the real world by physically holding in his or her hand an object that is able to interact with and virtually attract and contain items (e.g., objects with characteristics and behaviors) removed from or expellable into the virtual world. The resulting highly intuitive user interface provides fun and exciting video game play and has other applications as well.

Abstract: In-game characters select the proper animation to use depending on the state of the terrain on which they are currently moving. In this specific case the character chooses an animation depending on the angle of the ground on which it is walking. The method involves real-time determination of the ground angle which is then used to choose the most desirable animation from a closed set of pre-created animations. The animation set consists of animations rendered with the character moving on flat terrain, as well as animations rendered of the character moving uphill and downhill (separately) at pre-determined angles. In this game an animation set consisted of the following animations: 0 degrees, 15 degrees uphill, 30 degrees uphill, 45 degrees uphill, 15 degrees downhill, 30 degrees downhill, 45 degrees downhill). Drawing of the animation is offset to give the best appearance relative to the ground angle.

Abstract: A touch-based computer graphics user interface enhances a stylus pen with virtual suction to create a virtual vacuum or suction tool. The virtual tool may simulate a physical world suction tool and/or provide capabilities not available in the real world. The virtual suction tool allows the user to feel as if he or she has transcended the boundary between the virtual world and the real world by physically holding in his or her hand an object that is able to interact with and virtually attract and contain items (e.g., objects with characteristics and behaviors) removed from or expellable into the virtual world. The resulting highly intuitive user interface provides fun and exciting video game play and has other applications as well.