Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to a thermostat including a user interface module. The user interface module has a display, a plurality of user interface buttons, and a first power and communications interface. The thermostat also includes an I/O module, the I/O module electrically coupled to a HVAC plant and the I/O module having a plurality of switches to control the HVAC plant, and a second power and communications interface. The user interface module and the I/O module are communicatively coupled and exchange power via the power and communications interfaces and the thermostat can be mounted and operated in one of two user selectable installations: a stacked configuration comprising a thermostat having the user interface module directly mounted to the I/O module, or a remote configuration comprising a thermostat having the user interface module remotely mounted from the I/O module.

Abstract: The invention relates to a thermostat including a user interface module. The user interface module has a display, a plurality of user interface buttons, and a first power and communications interface. The thermostat also includes an I/O module, the I/O module electrically coupled to a HVAC plant and the I/O module having a plurality of switches to control the HVAC plant, and a second power and communications interface. The user interface module and the I/O module are communicatively coupled and exchange power via the power and communications interfaces and the thermostat can be mounted and operated in one of two user selectable installations: a stacked configuration comprising a thermostat having the user interface module directly mounted to the I/O module, or a remote configuration comprising a thermostat having the user interface module remotely mounted from the I/O module.

Abstract: A method and apparatus for reformatting terrain data that in turn increases compressibility of the terrain data. The method includes storing each sample of terrain data as a signed integer offset in hundreds of feet from a previous sample of terrain data; compressing the each sample of terrain data using RLE compression; and further compressing each sample of terrain data using Huffman compression. The signed integer offsets may be mapped to unsigned integer offsets from a minimum elevation to further reduce storage requirements.

Abstract: A critical point on a runway indicates a point at which an aircraft may experience a runway overrun if landing beyond the critical point. A path projection is extended from the aircraft at a descent slope angle to determine whether the aircraft will land beyond the critical point at the current descent slope. Timely alerts may be provided by accounting for the time required to announce a distance value, and the distance traveled during the announcement.

Abstract: A critical point on a runway indicates a point at which an aircraft may experience a runway overrun if landing beyond the critical point. A path projection is extended from the aircraft at a descent slope angle to determine whether the aircraft will land beyond the critical point at the current descent slope. Timely alerts may be provided by accounting for the time required to announce a distance value, and the distance traveled during the announcement.

Abstract: A critical point on a runway indicates a point at which an aircraft may experience a runway overrun if landing beyond the critical point. A path projection is extended from the aircraft at a descent slope angle to determine whether the aircraft will land beyond the critical point at the current descent slope. Timely alerts may be provided by accounting for the time required to announce a distance value, and the distance traveled during the announcement.

Abstract: A tower unit for a personal computer wherein the tower unit is a generally rectangular box having a generally rectangular interior chassis. The interior chassis includes a first set of interiorly extending mounting flanges and tabs which are positioned and aligned on opposing chassis walls to mount one or more drives at an upwardly facing angle in order to allow the user visual and manual access to the drives for ease of operation. A similar combination of interiorly directed tabs and flanges are formed in the opposing side walls of the frame near the bottom of the tower unit chassis in order to mount a plurality of hard disk drives in horizontal positions. The frame includes a front frame panel which combines with the front bezel to provide a gripping area which cooperates with another gripping area formed in the rear bezel to allow the tower unit to be easily moved about.

Abstract: A tower unit for a personal computer wherein the tower unit is a generally rectangular box having a generally rectangular interior chassis. The interior chassis includes a first set of interiorly extending mounting flanges and tabs which are positioned and aligned on opposing chassis walls to mount one or more drives at an upwardly facing angle in order to allow the user visual and manual access to the drives for ease of operation. A similar combination of interiorly directed tabs and flanges are formed in the opposing side walls of the frame near the bottom of the tower unit chassis in order to mount a plurality of hard disk drives in horizontal positions. The frame includes a front frame panel which combines with the front bezel to provide a gripping area which cooperates with another gripping area formed in the rear bezel to allow the tower unit to be easily moved about.