Abstract: Azlactone-functional polymer beads are useful reactive supports for the attachment of functional materials to provide novel adduct beads. The adduct beads are useful as complexing agents, catalysts, reagents, and as enzyme or other protein-bearing supports. Novel carboxylate-functional polymer beads, are intermediates in the preparation of the azlactone-functional beads.Azlactone-functional beads have units of the formula: ##STR1## wherein R.sup.1 is H or CH.sub.3,R.sup.2 and R.sup.3 independently can be an alkyl group having 1 to 14 carbon atoms, a cycloalkyl group having 3 to 14 carbon atoms, an aryl group having 5 to 12 ring atoms, an arenyl group having 6 to 26 carbon and 0 to 3 S, N, and nonperoxidic O heteroatoms, or R.sup.1 and R.sup.3 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms,andn is an integer 0 or 1.

Abstract: A novel class of chelated radio-labeled polysaccharide derivatives are useful for diagnosing formed, and forming, blood clots in a vascular system. Novel intermediate metal-binding compounds comprise a water-soluble polysaccharide moiety having an average of at least 0.25 anionic groups per monosaccharide unit, and at least one chelating group derived from amino acids, substituted cyclic acid anhydrides, or carbon disulfide. The intermediate compound is then reacted with a radioactive tracer metal compound.