Patents by Inventor Deana DiCosimo

Deana DiCosimo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for chromosomal expression of foreign genes in the hsdM region of a methylotrophic microbial host cell
    Publication number: 20070065903
    Abstract: Provided is a method for stably expressing an introduced gene or genes in a methylotrophic microorganism host wherein the gene(s) are integrated into the hsdM region of the chromosome. This method provides stable, high-level expression of the integrated genes in which growth rate of the host strain is not highly affected and a selection marker is not required. The use of this method for expressing carotenoid biosynthetic genes and resulting production of astaxanthin is also described.
    Type: Application
    Filed: September 19, 2005
    Publication date: March 22, 2007
    Inventors: Deana Dicosimo, Pamela Sharpe
  • Process for chromosomal expression of foreign genes in the cytochrome-C peroxidase (cytCP) region of a methylotrophic microbial host cell
    Publication number: 20070065900
    Abstract: Provided is a method for expressing an introduced gene or genes in a methylotrophic microorganism host wherein the gene(s) are integrated into the cytCP region of the chromosome. This method provides stable, high-level expression of the integrated genes in which growth rate of the host strain is not highly affected and a selection marker is not required. The use of this method for expressing carotenoid biosynthetic genes and resulting production of astaxanthin is also described.
    Type: Application
    Filed: September 19, 2005
    Publication date: March 22, 2007
    Inventors: Deana Dicosimo, Pamela Sharpe
  • Process for chromosomal expression of foreign genes in the fliC region of a methylotrophic microbial host cell
    Publication number: 20070065902
    Abstract: Provided is a method for expressing an introduced gene or genes in a methylotrophic microorganism host wherein the gene(s) are integrated into the fliC region of the chromosome. This method provides stable, high-level expression of the integrated genes in which growth rate of the host strain is not adversely affected and a selection marker is not required. The use of this method for expressing carotenoid biosynthetic genes and resulting production of astaxanthin is also described.
    Type: Application
    Filed: September 19, 2005
    Publication date: March 22, 2007
    Inventors: Deana Dicosimo, Pamela Sharpe
  • Process for chromosomal expression of foreign genes in the PAPS reductase (cysH) region of a methylotrophic microbial host cell
    Publication number: 20070065901
    Abstract: Provided is a method for stably expressing an introduced gene or genes in a methylotrophic microorganism host wherein the gene(s) are integrated into the cysH region of the chromosome. This method provides stable, high-level expression of the integrated genes in which growth rate and/or viability of the host strain is not significantly affected and a selection marker is not required. The use of this method for expressing carotenoid biosynthetic genes and resulting production of carotenoids is also described.
    Type: Application
    Filed: September 19, 2005
    Publication date: March 22, 2007
    Inventors: Deana Dicosimo, Pamela Sharpe
  • Natural promoters for gene expression in C1 metabolizing bacteria
    Publication number: 20060036088
    Abstract: Genes have been identified in the Methylomonas genome that are responsive to various metabolic and growth conditions. The identified responsiveness of these genes allows for the use of their promoters in regulated gene expression in C1 metabolizing bacteria. In particular, the hps promoter, which in its native state drives the expression of 3-hexulose-6-phosphate synthase (HPS), was found to be useful for directing expression of heterolgous coding regions (e.g., crtZ) in the obligate methanotroph Methylomonas sp. 16a.
    Type: Application
    Filed: October 14, 2005
    Publication date: February 16, 2006
    Inventors: Deana Dicosimo, Hao Ni, Stephen Picataggio, John Seip, Rick Ye, Tao Wang
  • Carotenoid production from a single carbon substrate
    Patent number: 6969595
    Abstract: A method for the production of carotenoid compounds is disclosed. The method relies on the use of microorganisms which metabolize single carbon substrates for the production of carotenoid compounds in high yields.
    Type: Grant
    Filed: August 29, 2001
    Date of Patent: November 29, 2005
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Patricia C. Brzostowicz, Qiong Cheng, Deana DiCosimo, Mattheos Koffas, Edward S. Miller, James M. Odom, Stephen K. Picataggio, Pierre E. Rouviere
  • Carotenoid production from a single carbon substrate
    Publication number: 20030003528
    Abstract: A method for the production of carotenoid compounds is disclosed. The method relies on the use of microorganisms which metabolize single carbon substrates for the production of carotenoid compounds in high yields.
    Type: Application
    Filed: August 29, 2001
    Publication date: January 2, 2003
    Inventors: Patricia C. Brzostowicz, Qiong Cheng, Deana Dicosimo, Mattheos Koffas, Edward S. Miller, James M. Odom, Stephen K. Picataggio, Pierre E. Rouviere