Abstract: The present application discloses compounds having the following formula: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

Abstract: The present application discloses compounds having the following formula: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

Abstract: The present application discloses compounds having the following formula: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

Abstract: The present application discloses compounds having the following formula: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

Abstract: The present application discloses compounds having the following formula: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

Abstract: The present application discloses compounds having the following formula: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

Abstract: The present application relates to certain substituted imidazole compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating pain, musculoskeletal inflammation, neuroinflammatory disorders, airway inflammation, itch, dermatitis, colitis and related conditions.

Abstract: The present application relates to certain substituted imidazole compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating pain, musculoskeletal inflammation, neuroinflammatory disorders, airway inflammation, itch, dermatitis, colitis and related conditions.

Abstract: The present application relates to certain substituted imidazole and triazole compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating pain, musculoskeletal inflammation, neuroinflammatory disorders, airway inflammation, itch, dermatitis, colitis and related conditions. The compounds are of Formula (I) where X is N or CH, Z and Y are N or C (but both not N) and R1-R3 are as defined herein.

Abstract: The present application relates to certain substituted imidazole and triazole compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating pain, musculoskeletal inflammation, neuroinflammatory disorders, airway inflammation, itch, dermatitis, colitis and related conditions. The compounds are of Formula (I) where X is N or CH, Z and Y are N or C (but both not N) and R1-R3 are as defined herein.

Abstract: Adjustable signage for securement to storage structure utilizes a fixed header securable to such storage structure, a pivotable header pivotally secured to the fixed header along a length thereof, a clip removably received by the pivotable header for mounting a sign to the pivotable header, and at least one latch mechanism for holding the pivotable header in a first, upright orientation relative to the storage structure and for releasing the pivotable header to permit lowering thereof to a second, lowered orientation, so as to provide access to inventory in the storage structure normally hidden from view by the sign when the pivotable header is in the upright orientation.

Abstract: Packet switch operating methods and packet switches, using first processing circuitry of the packet switch, specify a configuration for a control packet processing procedure implemented by different second processing circuitry of the packet switch, communicate the configuration to the second processing circuitry, and using the second processing circuitry, receive a control packet, examine contents of the control packet, and process the control packet according to the control packet processing procedure, the control packet processing procedure being configured according to the configuration.

Abstract: Packet switch operating methods and packet switches, using first processing circuitry of the packet switch, configure different second processing circuitry of the packet switch to periodically transmit control packets to a destination device via a port of the packet switch and, subsequent to the configuring and using the second processing circuitry, transmit the control packets to the destination device via the port during moments in time when the first processing circuitry is non-operational.

Abstract: This document describes tools that communicate an operational state of a transport service. The transport service provides connectivity between two or more networks, enabling the networks to exchange packets. The tools detect an operational state of a transport service. After doing so, the tools may convey the operational state of the transport service to at least one of the networks through a user-to-network interface port of a network interface device, send a message to a network interface device requesting that the network interface device convey the operational state to a network connected to the network interface device, or configure a network interface device to communicate the operational state.

Abstract: A method of forming a fabric is provided. The method includes the step of providing a plurality of yarn and batching the yarn on an A-frame so that the fabric is formed with a width greater than 102 inches and with a twill weave with a satin face. Also included is the step of passing the fabric across a plurality of rolls that have a rough surface and that apply compression to the fabric. The steps of applying fabric to a tenter frame and heating of the fabric is also included. The present invention also provides for a fabric in certain exemplary embodiments.

Abstract: A method of forming a fabric is provided. The method includes the step of providing a plurality of yarn and batching the yarn on an A-frame so that the fabric is formed with a width greater than 102 inches and with a twill weave with a satin face. Also included is the step of passing the fabric across a plurality of rolls that have a rough surface and that apply compression to the fabric. The steps of applying fabric to a tenter frame and heating of the fabric is also included. The present invention also provides for a fabric in certain exemplary embodiments.

Abstract: This document describes tools that communicate an operational state of a transport service. The transport service provides connectivity between two or more networks, enabling the networks to exchange packets. The tools detect an operational state of a transport service. After doing so, the tools may convey the operational state of the transport service to at least one of the networks through a user-to-network interface port of a network interface device, send a message to a network interface device requesting that the network interface device convey the operational state to a network connected to the network interface device, or configure a network interface device to communicate the operational state.

Abstract: A method of forming a fabric is provided. The method includes the step of providing a plurality of yarn and batching the yarn on an A-frame so that the fabric is formed with a width greater than 102 inches and with a twill weave with a satin face. Also included is the step of passing the fabric across a plurality of rolls that have a rough surface and that apply compression to the fabric. The steps of applying fabric to a tenter frame and heating of the fabric is also included. The present invention also provides for a fabric in certain exemplary embodiments.

Abstract: Compounds according to structural diagram (I) are disclosed, wherein R1, A, E and D are as defined in the specification. Also disclosed are pharmaceutical compositions comprising a pain-ameliorating effective amount of a compound in accord with structural diagram (I). The following is an examiner's statement of reasons for allowance: In view of applicants' amendments to the claims which limit “E” to phenyl or cycloalkyl groups the rejections of the previous action no longer pertain as they at best teach “E” as alkyl.

Abstract: A compound, 7-chloro-4-hydroxy-2-(2-chloro-4-methylphenyl)-1,2,5,10-tetrahydropyridazino [4,5-b]quinoline-1,10-dione, pharmaceutically-acceptable salts thereof, a method for treating pain comprising administration of a pain-ameliorating effective amount of the compound and pharmaceutical compositions containing the compound.